Steroid treatment in four cases of anti-GAD cerebellar ataxia;Traitement des ataxies cérébelleuses à anticorps anti-GAD par cures séquentielles de corticoïdes

Revue Neurologique

Volumn 164, Issue 5, 2008, Pages 427-433

  Bonnan, M ^a   Cabre, P ^a   Olindo, S ^a   Signate, A ^a   Saint Vil, M ^a   Smadja, D ^a  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE FORT DE FRANCE   (France)

Author keywords

Cerebellar ataxia; Glutamic acid decarboxylase antibody; Methylprednisolone

Indexed keywords

AZATHIOPRINE; CYCLOPHOSPHAMIDE; DIAZEPAM; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE ANTIBODY; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; PLACEBO; VALPROIC ACID;

ADULT; AGED; ARTICLE; CASE REPORT; CEREBELLAR ATAXIA; CLINICAL FEATURE; CORTICOSTEROID THERAPY; DRUG PULSE THERAPY; FEMALE; HUMAN; PLASMAPHERESIS;

ADULT; AGED; ANTI-INFLAMMATORY AGENTS; AUTOANTIBODIES; CEREBELLAR ATAXIA; FEMALE; FOLLOW-UP STUDIES; GLUTAMATE DECARBOXYLASE; HUMANS; MIDDLE AGED; STEROIDS;

EID: 45949105934     PISSN: 00353787     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurol.2008.02.032     Document Type: Article

References (39)

1. Abele M., Weller M., Mescheriakov S., Burk K., Dichgans J., and Klockgether T. Cerebellar ataxia with glutamic acid decarboxylase autoantibodies. Neurology 52 (1999) 857-859
2. Abele M., Burk K., Schols L., et al. The aetiology of sporadic adult-onset ataxia. Brain 125 (2002) 961-968
3. Amato A.A., Cornman E.W., and Kissel J.T. Treatment of stiff-man syndrome with intravenous immunoglobulin. Neurology 44 (1994) 1652-1654
4. Barker R.A., Revesz T., Thom M., Marsden C.D., and Brown P. Review of 23 patients affected by the stiff man syndrome: clinical subdivision into stiff trunk (man) syndrome, stiff limb syndrome, and progressive encephalomyelitis with rigidity. J Neurol Neurosurg Psychiatry 65 (1998) 633-640
5. Birand B., Cabre P., Bonnan M., Olindo S., and Smadja D. Un nouveau cas d'ataxie cérébelleuse à anticorps anti-GAD traité par corticoïdes et initialement séronégatif. Rev Med Interne 27 (2006) 616-619
6. Burns T.M., Philips L.H., and Jones H.R. Stiff person does not always occur with maternal passive transfert of GAD65 antibodies. Neurology 64 (2005) 399-400
7. Cabre P., Smadja D., Humbel R.L., Merle H., and Vernant J.C. Progressive encephalomyelitis with rigidty, Diabetes mellitus, and retinopathy: an anti-GAD syndrome. Eur J Neurol 3 (1996) 98-101
8. Chang C., Eggers S.D., Johnson J.K., Haman A., Miller B.L., and Geschwind M.D. Anti-GAD antibodies cerebellar ataxia mimicking Creutzfeldt-Jakob disease. Clin Neurol Neurosurg 109 (2006) 54-57
9. Dalakas M.C., Li M., Fujii M., and Jacobowitz D.M. Stiff person syndrome: quantification, specificity, and intrathecal synthesis of GAD65 antibodies. Neurology 57 (2001) 780-784
10. Dalakas M.C. The role of IVIg in the treatment of patients with stiff person syndrome and other neurological diseases associated with anti-GAD antibodies. J Neurol 252 Suppl. 1 (2005) I19-I25
11. Giometto B., Miotto D., Faresin F., Argentiero V., Scaravilli T., and Tavolato B. Anti-gabaergic neuron autoantibodies in a patient with stiff-man syndrome and ataxia. J Neurol Sci 143 (1996) 57-59
12. Giometto B., Nicolao P., Macucci M., Tavolato B., Foxon R., and Bottazzo G.F. Temporal-lobe epilepsy associated with glutamic-acid-decarboxylase autoantibodies. Lancet 352 (1998) 457
13. Hao W., Davis C., Daniels T., Hampe C.S., and Lernmark A. Epitope-specific glutamic acid decarboxylase-65 autoantibodies in intravenous immunoglobulin preparations. Transfus Med 9 (1999) 307-310
14. Hernandez-Echebarria L., Saiz A., Ares A., et al. Paraneoplastic encephalomyelitis associated with pancreatic tumor and anti-GAD antibodies. Neurology 66 (2006) 450-451
15. Honnorat J., Trouillas P., Thivolet C., Aguera M., and Belin M.F. Autoantibodies to glutamate decarboxylase in a patient with cerebellar cortical atrophy, peripheral neuropathy, and slow eye movements. Arch Neurol 52 (1995) 462-468
16. Honnorat J., Saiz A., Giometto B., et al. Cerebellar ataxia with anti-glutamic acid decarboxylase antibodies: study of 14 patients. Arch Neurol 58 (2001) 225-230
17. Ishida K., Mitoma H., Song S.Y., et al. Selective suppression of cerebellar GABAergic transmission by an autoantibody to glutamic acid decarboxylase. Ann Neurol 46 (1999) 263-267
18. Kim J., Namchuk M., Bugawan T., et al. Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD6s, distinguish stiff-man syndrome from insulin-dependent Diabetes mellitus. J Exp Med 180 (1994) 595-606
19. Lauria G., Pareyson D., Pitzolu M.G., and Bazzigaluppi E. Excellent response to steroid treatment in anti-GAD cerebellar ataxia. Lancet Neurol 2 (2003) 634-635
20. Link H., and Tibbling G. Principles of albumin and IgG analyses in neurological disorders. III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis. Scand J Clin Lab Invest 37 (1977) 397-401
21. Manto M.U., Laute M.A., Aguera M., Rogemond V., Pandolfo M., and Honnorat J. Effects of anti-glutamic acid decarboxylase antibodies with neurological diseases. Ann Neurol 61 (2007) 544-551
22. Marchiori G.C., Vaglia A., Vianello M., Bardin P.G., and Giometto B. Encephalitis associated with glutamic acid decarboxylase autoantibodies. Neurology 56 (2001) 814
23. Matsumoto S., Kusuhara T., Nakajima M., Ouma S., Takahashi M., and Yamada T. Acute attacks and brain stem signs in a patient with glutamic acid decarboxylase autoantibodies. J Neurol Neurosurg Psychiatry 73 (2002) 345-346
24. McFarland N.R., Login I.S., Vernon S., and Burns T.M. Improvement with corticosteroids and azathioprine in GAD65-associated cerebellar ataxia. Neurology 67 (2006) 1308-1309
25. Mitoma H., Ishida K., Shizuka-Ikeda M., and Mizusawa H. Dual impairment of GABAA- and GABAB-receptor-mediated synaptic responses by autoantibodies to glutamic acid decarboxylase. J Neurol Sci 208 (2003) 51-56
26. Moldovanu I.V., Chubar A.V., and Chuchin M.I. The stiff man syndrome. Zh Nevropatol Psikhiatr Im S S Korsakova 86 (1986) 1641-1646 [abstract]
27. Peltola J., Kulmala P., Isojarvi J., et al. Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy. Neurology 55 (2000) 46-50
28. Rakocevic G., Raju R., and Dalakas M.C. Anti-glutamic acid decarboxylase antibodies in the serum and cerebrospinal fluid of patients with stiff-person syndrome: correlation with clinical severity. Arch Neurol 61 (2004) 902-904
29. Rakocevic G., Raju R., Semino-Mora C., and Dalakas M.C. Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies. Neurology 67 (2006) 1068-1070
30. Saiz A., Arpa J., Sagasta A., et al. Autoantibodies to glutamic acid decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent Diabetes mellitus, and polyendocrine autoimmunity. Neurology 49 (1997) 1026-1030
31. Selim M., and Drachman D.A. Ataxia associated with Hashimoto's disease: progressive non-familial adult onset cerebellar degeneration with autoimmune thyroiditis. J Neurol Neurosurg Psychiatr 71 (2001) 81-87
32. Shams'ili S., Grefkens J., de Leeuw B., et al. Paraneoplastic cerebellar degeneration associated with antineuronal antibodies: analysis of 50 patients. Brain 126 (2003) 1409-1418
33. Solimena M., Folli F., Denis-Donini S., et al. Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I Diabetes mellitus. N Engl J Med 318 (1988) 1012-1020
34. Steffen H., Menger N., Richter W., et al. Immune-mediated retinopathy in a patient with stiff-man syndrome. Graefes Arch Clin Exp Ophthalmol 237 (1999) 212-219
35. Takenoshita H., Shizuka-Ikeda M., Mitoma H., et al. Presynaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxia. J Neurol Neurosurg Psychiatry 70 (2001) 386-389
36. Trivedi R., Mundanthanam G., Amyes E., Lang B., and Vincent A. Autoantibody screening in subacute cerebellar ataxia. Lancet 356 (2000) 565-566
37. Trouillas P., Takayanagi T., Hallett M., et al. International Cooperative Ataxia Rating Scale for pharmacological assessment of the cerebellar syndrome. The Ataxia Neuropharmacology Committee of the World Federation of Neurology. J Neurol Sci 145 (1997) 205-211
38. Vianello M., Tavolato B., and Giometto B. Glutamic acid decarboxylase autoantibodies and neurological disorders. Neurol Sci 23 (2002) 145-151
39. Yoshimoto T., Doi M., Fukai N., et al. Type 1 Diabetes mellitus and drug-resistant epilepsy: presence of high titer of anti-glutamic acid decarboxylase autoantibodies in serum and cerebrospinal fluid. Intern Med 44 (2005) 1174-1177