-
1
-
-
45949090764
-
-
Chen, S, Sun, L, Ono, M, Koya, K, Xia, Z.-Q, SBR Pharmaceuticals Corp, Synthesis of taxol enhancers. US 2003069225, US 6825235, WO 03006429
-
Chen, S., Sun, L., Ono, M., Koya, K., Xia, Z.-Q. (SBR Pharmaceuticals Corp.). Synthesis of taxol enhancers. US 2003069225, US 6825235, WO 03006429.
-
-
-
-
2
-
-
45949103663
-
-
Koya, K, Sun, L, Ono, M, Tatsuta, N, Wu, Y, Chen, S, Synta Pharmaceuticals Corp, Taxol enhancer compounds. EP 1406869, EP 1731148, JP 2004534848, US 2003119914, WO 03006430
-
Koya, K., Sun, L., Ono, M., Tatsuta, N., Wu, Y., Chen, S. (Synta Pharmaceuticals Corp.). Taxol enhancer compounds. EP 1406869, EP 1731148, JP 2004534848, US 2003119914, WO 03006430.
-
-
-
-
3
-
-
45949084553
-
-
Kostik, E, Vaghefi, F, Liang, G. et al, Synta Pharmaceuticals Corp, EP 1781604, WO 2006009940
-
Kostik, E., Vaghefi, F., Liang, G. et al. (Synta Pharmaceuticals Corp.). EP 1781604, WO 2006009940.
-
-
-
-
4
-
-
33645092920
-
Cutaneous melanoma: Available therapy for metastatic disease
-
Tarhini, A.A., Agarwala, S.S. Cutaneous melanoma: Available therapy for metastatic disease. Dermatol Ther 2006, 19(1): 19-25.
-
(2006)
Dermatol Ther
, vol.19
, Issue.1
, pp. 19-25
-
-
Tarhini, A.A.1
Agarwala, S.S.2
-
5
-
-
13844312037
-
Cutaneous melanoma
-
Thompson, J.F., Scolyer, R.A., Kefford, R.F. Cutaneous melanoma. Lancet 2005, 365(9460): 687-701.
-
(2005)
Lancet
, vol.365
, Issue.9460
, pp. 687-701
-
-
Thompson, J.F.1
Scolyer, R.A.2
Kefford, R.F.3
-
6
-
-
33847349283
-
Reactive oxygen species: A breath of life or death?
-
Fruehauf, J.P., Meyskens, F.L. Jr. Reactive oxygen species: A breath of life or death? Clin Cancer Res 2007, 13(3): 789-94.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.3
, pp. 789-794
-
-
Fruehauf, J.P.1
Meyskens Jr., F.L.2
-
7
-
-
33748165596
-
Reactive oxygen species in cancer cells: Live by the sword, die by the sword
-
Schumacker, P.T. Reactive oxygen species in cancer cells: Live by the sword, die by the sword. Cancer Cell 2006, 10(3): 175-6.
-
(2006)
Cancer Cell
, vol.10
, Issue.3
, pp. 175-176
-
-
Schumacker, P.T.1
-
8
-
-
2942593991
-
ROS stress in cancer cells and therapeutic implications
-
Pelicano, H., Carney, D., Huang, P. ROS stress in cancer cells and therapeutic implications. Drug Resist Updat 2004, 7(2): 97-110.
-
(2004)
Drug Resist Updat
, vol.7
, Issue.2
, pp. 97-110
-
-
Pelicano, H.1
Carney, D.2
Huang, P.3
-
9
-
-
45949110068
-
-
Overview of elesclomol (formerly STA-4783) in metastatic melanoma, November
-
Overview of elesclomol (formerly STA-4783) in metastatic melanoma. Synta Pharmaceuticals Presentation, November 2007.
-
(2007)
Synta Pharmaceuticals Presentation
-
-
-
10
-
-
45949109323
-
The taxane-enhancer STA-4783 induces Hsp70 expression and apoptosis via an oxidative stress mechanism
-
Abst 14107
-
Kirshner, J., Du, Z., Kepros, J. et al. The taxane-enhancer STA-4783 induces Hsp70 expression and apoptosis via an oxidative stress mechanism. J Clin Oncol [43rd Annu Meet Am Soc Clin Oncol (ASCO) (June 1-5, Chicago) 2007] 2007, 25(18, Suppl.): Abst 14107.
-
J Clin Oncol [43rd Annu Meet Am Soc Clin Oncol (ASCO) (June 1-5, Chicago) 2007] 2007, 25(18, Suppl.)
-
-
Kirshner, J.1
Du, Z.2
Kepros, J.3
-
11
-
-
45949101326
-
The novel small molecule elesclomol (formerly STA-4783) induces apoptosis in cancer cells through induction of oxidative stress
-
Oct 22-26, San Francisco, Abst B274
-
Kirshner, J., Du, Z., Kepros, J. et al. The novel small molecule elesclomol (formerly STA-4783) induces apoptosis in cancer cells through induction of oxidative stress. AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther (Oct 22-26, San Francisco) 2007, Abst B274.
-
(2007)
AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther
-
-
Kirshner, J.1
Du, Z.2
Kepros, J.3
-
14
-
-
33745159204
-
STA-4783, a novel HSP70 inducer, enhances the anti-cancer activity of paclitaxel without increasing toxicity in preclinical studies
-
Abst 1504
-
Koya, K., Sun, L., Chen, S. et al. STA-4783, a novel HSP70 inducer, enhances the anti-cancer activity of paclitaxel without increasing toxicity in preclinical studies. Proc Am Assoc Cancer Res (AACR) 2004, 45: Abst 1504.
-
(2004)
Proc Am Assoc Cancer Res (AACR)
, vol.45
-
-
Koya, K.1
Sun, L.2
Chen, S.3
-
15
-
-
77953026383
-
The oxidative stress inducer elesclomol (formerly STA-4783) enhances the in vivo efficacy of multiple anti-cancer therapies in mouse tumor models
-
Oct 22-26, San Francisco, Abst A290
-
Foley, K.P., Allen, I., Bertin, J. et al. The oxidative stress inducer elesclomol (formerly STA-4783) enhances the in vivo efficacy of multiple anti-cancer therapies in mouse tumor models. AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther (Oct 22-26, San Francisco) 2007, Abst A290.
-
(2007)
AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther
-
-
Foley, K.P.1
Allen, I.2
Bertin, J.3
-
16
-
-
33745120037
-
A novel HSP-70 inducer STA-4783 enhances the anticancer activity of paclitaxel without altering paclitaxel pharmacokinetics. Preclinical pharmacokinetics, distribution and excretion study of STA-4783
-
Abst 2125
-
Tatsuta, N., Liang, G., Wang, Q. et al. A novel HSP-70 inducer STA-4783 enhances the anticancer activity of paclitaxel without altering paclitaxel pharmacokinetics. Preclinical pharmacokinetics, distribution and excretion study of STA-4783. Proc Am Assoc Cancer Res (AACR) 2004, 45: Abst 2125.
-
(2004)
Proc Am Assoc Cancer Res (AACR)
, vol.45
-
-
Tatsuta, N.1
Liang, G.2
Wang, Q.3
-
17
-
-
33846856501
-
Phase I clinical trial of STA-4783 in combination with paclitaxel in patients with refractory solid tumors
-
Berkenblit, A., Eder, J.P. Jr., Ryan, D.P. et al. Phase I clinical trial of STA-4783 in combination with paclitaxel in patients with refractory solid tumors. Clin Cancer Res 2007, 13(2): 584-90.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.2
, pp. 584-590
-
-
Berkenblit, A.1
Eder Jr., J.P.2
Ryan, D.P.3
-
18
-
-
45949097151
-
STA-4783 in combination with paclitaxel induces heat shock protein 70 (hsp70) in a phase I trial
-
ASCO, May 13-17, Orlando, Abst 2011
-
Berkenblit, A., Supko, J., Ryan, D.P. et al. STA-4783 in combination with paclitaxel induces heat shock protein 70 (hsp70) in a phase I trial. 41st Annu Meet Am Soc Clin Oncol (ASCO) (May 13-17, Orlando) 2005, Abst 2011.
-
(2005)
41st Annu Meet Am Soc Clin Oncol
-
-
Berkenblit, A.1
Supko, J.2
Ryan, D.P.3
-
19
-
-
45949098824
-
Pre-clinical toxicology evaluation of STA-4783 alone or combination with paclitaxel in rats, mice, and dogs
-
Abst 2112
-
Zhou, D., McKeon, M.E., Dahl, T. et al. Pre-clinical toxicology evaluation of STA-4783 alone or combination with paclitaxel in rats, mice, and dogs. Proc Am Assoc Cancer Res (AACR) 2004, 45: Abst 2112.
-
(2004)
Proc Am Assoc Cancer Res (AACR)
, vol.45
-
-
Zhou, D.1
McKeon, M.E.2
Dahl, T.3
-
20
-
-
45949111918
-
-
STA-4783 in combination with paclitaxel and carboplatin for the treatment of chemotherapy naive patients with stage IIIB/IV non small cell lung cancer (NSCLC) (NCT00088088). ClinicalTrials.gov Web site, March 13, 2008.
-
STA-4783 in combination with paclitaxel and carboplatin for the treatment of chemotherapy naive patients with stage IIIB/IV non small cell lung cancer (NSCLC) (NCT00088088). ClinicalTrials.gov Web site, March 13, 2008.
-
-
-
-
21
-
-
33745132008
-
A phase 1/2 study of STA-4783 in combination with paclitaxel and carboplatin in chemo-naive advanced non-small cell lung cancer (NSCLC)
-
ASCO, May 13-17, Orlando, Abst 7106
-
Jacobs, M., Weber, R., Hainsworth, J. et al. A phase 1/2 study of STA-4783 in combination with paclitaxel and carboplatin in chemo-naive advanced non-small cell lung cancer (NSCLC). 41st Annu Meet Am Soc Clin Oncol (ASCO) (May 13-17, Orlando) 2005, Abst 7106.
-
(2005)
41st Annu Meet Am Soc Clin Oncol
-
-
Jacobs, M.1
Weber, R.2
Hainsworth, J.3
-
22
-
-
45949111151
-
Results of a phase 2 study of STA-4783 in combination with paclitaxel and carboplatin in patients with previously untreated advanced non-small cell lung cancer (NSCLC)
-
Nov 14-18, Philadelphia, Abst B112
-
Hainsworth, J., Weber, R., Jacobs, M. et al. Results of a phase 2 study of STA-4783 in combination with paclitaxel and carboplatin in patients with previously untreated advanced non-small cell lung cancer (NSCLC). 17th AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther (Nov 14-18, Philadelphia) 2005, Abst B112.
-
(2005)
17th AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther
-
-
Hainsworth, J.1
Weber, R.2
Jacobs, M.3
-
23
-
-
33745156302
-
Phase 1/2 study of STA-4783, a novel heat shock protein 70 (hsp70) inducer, in combination with paclitaxel in patients with soft tissue sarcomas (STS)
-
ASCO, May 13-17, Orlando, Abst 9069
-
Sherman, M.L., Ryan, C., Blackstein, M. et al. Phase 1/2 study of STA-4783, a novel heat shock protein 70 (hsp70) inducer, in combination with paclitaxel in patients with soft tissue sarcomas (STS). 41st Annu Meet Am Soc Clin Oncol (ASCO) (May 13-17, Orlando) 2005, Abst 9069.
-
(2005)
41st Annu Meet Am Soc Clin Oncol
-
-
Sherman, M.L.1
Ryan, C.2
Blackstein, M.3
-
24
-
-
45949111628
-
Preliminary results of a phase 2 study of the novel heat shock protein 70 (hsp70) inducer, STA-4783, in combination with paclitaxel in patients with soft tissue sarcomas
-
Nov 14-18, Philadelphia, Abst B108
-
Baker, L.H., Ryan, C., Agarwala, S. et al. Preliminary results of a phase 2 study of the novel heat shock protein 70 (hsp70) inducer, STA-4783, in combination with paclitaxel in patients with soft tissue sarcomas. 17th AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther (Nov 14-18, Philadelphia) 2005, Abst B108.
-
(2005)
17th AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther
-
-
Baker, L.H.1
Ryan, C.2
Agarwala, S.3
-
26
-
-
70350629420
-
A 2-stage controlled phase 1/2 study of STA-4783 in combination with paclitaxel in patients with advanced metastatic melanoma
-
ASCO, May 13-17, Orlando, Abst 7561
-
Powderly, J., Khan, K., Richards, J. et al. A 2-stage controlled phase 1/2 study of STA-4783 in combination with paclitaxel in patients with advanced metastatic melanoma. 41st Annu Meet Am Soc Clin Oncol (ASCO) (May 13-17, Orlando) 2005, Abst 7561.
-
(2005)
41st Annu Meet Am Soc Clin Oncol
-
-
Powderly, J.1
Khan, K.2
Richards, J.3
-
27
-
-
45949104564
-
A 2-stage, randomized, blinded phase 2 study of STA-4783 in combination with paclitaxel in patients with advanced metastatic melanoma
-
Nov 14-18, Philadelphia, Abst C95
-
Powderly, J., Khan, K., Urba, W. et al. A 2-stage, randomized, blinded phase 2 study of STA-4783 in combination with paclitaxel in patients with advanced metastatic melanoma. 17th AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther (Nov 14-18, Philadelphia) 2005, Abst C95.
-
(2005)
17th AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther
-
-
Powderly, J.1
Khan, K.2
Urba, W.3
-
28
-
-
45949102834
-
Oxidative stress induction: An old idea whose time has come. MOA and clinical correlates of the oxidative stress inducer STA4783
-
Sept 23-27, Barcelona, Abst 7002
-
Williams, A., Gonzalez, R., Lawson, D. et al. Oxidative stress induction: An old idea whose time has come. MOA and clinical correlates of the oxidative stress inducer STA4783. Eur J Cancer - Suppl [14th Eur Cancer Conf (ECCO) (Sept 23-27, Barcelona) 2007] 2007, 5(4): Abst 7002.
-
(2007)
Eur J Cancer - Suppl [14th Eur Cancer Conf (ECCO)
, vol.5
, Issue.4
-
-
Williams, A.1
Gonzalez, R.2
Lawson, D.3
-
29
-
-
45949096358
-
Subgroup analysis of efficacy and safety analysis of a randomized, double-blind-ed controlled phase 2 study of STA-4783 in combination with paclitaxel in patients with metastatic melanoma
-
Sept 5-8, Barcelona, Abst S2
-
O'Day, S., Gonzalez, R., Lawson, D. et al. Subgroup analysis of efficacy and safety analysis of a randomized, double-blind-ed controlled phase 2 study of STA-4783 in combination with paclitaxel in patients with metastatic melanoma. 1st World Meet Interdiscip Melanoma Skin Cancer Cent (Sept 5-8, Barcelona) 2007, Abst S2.
-
(2007)
1st World Meet Interdiscip Melanoma Skin Cancer Cent
-
-
O'Day, S.1
Gonzalez, R.2
Lawson, D.3
-
30
-
-
45949109168
-
Subgroup analysis of efficacy and safety analysis of a randomized, double-blinded controlled phase II study of STA-4783 in combination with paclitaxel in patients with metastatic melanoma
-
Abst 8528
-
O'Day, S., Gonzalez, R., Lawson, D. et al. Subgroup analysis of efficacy and safety analysis of a randomized, double-blinded controlled phase II study of STA-4783 in combination with paclitaxel in patients with metastatic melanoma. J Clin Oncol [43rd Annu Meet Am Soc Clin Oncol (ASCO) (June 1-5, Chicago) 2007] 2007, 25(18, Suppl.): Abst 8528.
-
J Clin Oncol [43rd Annu Meet Am Soc Clin Oncol (ASCO) (June 1-5, Chicago) 2007] 2007, 25(18, Suppl.)
-
-
O'Day, S.1
Gonzalez, R.2
Lawson, D.3
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