Active site of mycobacterial dUTPase: Structural characteristics and a built-in sensor

Biochemical and Biophysical Research Communications

Volumn 373, Issue 1, 2008, Pages 8-13

  Varga, Balázs ^a   Barabás, Orsolya ^a   Takács, Eniko ^a   Nagy, Nikolett ^a   Nagy, Péter ^a   Vértessy, Beáta G ^a  

^a INSTITUTE OF ENZYMOLOGY   (Hungary)

Author keywords

dUTPase; Enzyme kinetics; Fluorescence spectroscopy; Inhibitor screening; Mycobacterium tuberculosis; Pyrophosphate assay; Tryptophan sensor; Tuberculosis; Uracil

Indexed keywords

ALPHA,BETA IMIDO DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; BACTERIAL ENZYME; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; HISTIDINE; MAGNESIUM ION; TETRAPEPTIDE; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BINDING; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; MOLECULAR SENSOR; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DEOXYURACIL NUCLEOTIDES; ENZYME INHIBITORS; FLUORESCENCE; MAGNESIUM; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; PYROPHOSPHATASES; TRYPTOPHAN;

MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 45849136329     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.05.130     Document Type: Article

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