Evaluation of dimethyl sulphoxide effects on initial response to endotoxin in the horse

Equine Veterinary Journal

Volumn 40, Issue 4, 2008, Pages 358-363

  Kelmer, G ^a   Doherty, T J ^c   Elliott, S ^c   Saxton, A ^b   Fry, M M ^a   Andrews, F M ^c  

^a UNIVERSITY OF TENNESSEE   (United States)

^b UNIVERSITY OF TENNESSEE   (United States)

^c NONE

Author keywords

Dimethyl sulphoxide; Endotoxaemia; Horse; Lipopolysaccharide

Indexed keywords

DIMETHYL SULFOXIDE; ENDOTOXIN; LIPOPOLYSACCHARIDE;

ANALYSIS OF VARIANCE; ANIMAL; ANIMAL DISEASE; AREA UNDER THE CURVE; BODY TEMPERATURE; CHEMICALLY INDUCED DISORDER; CONFERENCE PAPER; DOSE RESPONSE; DRUG EFFECT; ENDOTOXEMIA; FEMALE; FEVER; HEART RATE; HORSE; HORSE DISEASE; HOSPITALIZATION; MALE; PHYSIOLOGY; RANDOMIZATION; TIME; TREATMENT OUTCOME;

ANALYSIS OF VARIANCE; ANIMALS; AREA UNDER CURVE; BODY TEMPERATURE; DIMETHYL SULFOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXEMIA; ENDOTOXINS; FEMALE; FEVER; HEART RATE; HORSE DISEASES; HORSES; LIPOPOLYSACCHARIDES; MALE; RANDOM ALLOCATION; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME;

EQUIDAE;

EID: 45849122447     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/042516408X293501     Document Type: Conference Paper

References (30)

1. Ainsworth, D. (2002) Treatment of endotoxemia. In: Equine Gastroenterology, Eds: T. Mair, T. Divers and N. Ducharme, W.B. Saunders, London. pp 191-196.
2. Alsup, E. and DeBowes, R. (1984) Dimethyl sulfoxide. J. Am. vet. med. Ass. 185, 1011-1014.
3. Arden, W.A., Slocombe, R.F., Stick, J.A. and Parks, A.H. (1990) Morphologic and ultrastructural evaluation of effect of ischemia and dimethyl sulfoxide on equine jejunum. Am. J. vet. Res. 51, 1784-1791.
4. Barton, M.H., Parviainen, A. and Norton, N. (2004) Polymyxin B protects horses against induced endotoxaemia in vivo. Equine vet. J. 36, 397-401.
5. Belknap, J.K. and Black, S.J. (2005) Review of the pathophysiology of the developmental stages of equine laminitis. In: Proc. Am. Ass. equine Practnrs. 51, 383-388.
6. Blythe, L.L., Craig, A.M., Christensen, J.M., Appell, L.H. and Slizeski, M.L. (1986) Pharmacokinetic disposition of dimethyl sulfoxide administered intravenously to horses. Am. J. vet. Res. 47, 1739-1743.
7. Brackett, D.J., Lerner, M.R. and Wilson, M.F. (1991) Dimethyl sulfoxide antagonizes hypotensive, metabolic, and pathologic responses induced by endotoxin. Circ. Shock. 33, 156-163.
8. Breen, R., Connell, R. and Harrison, M. (1983) The effects of dimethyl sulfoxide on endotoxin-induced pulmonary dysfunction: A biochemical and electron microscope study. Ann. N.Y. Acad. Sci. 411, 324-327.
9. Cetin, M., Eser, B., Er, O., Unal, A., Kilic, E., Patiroglu, T., Coskun, H.S., Altinbas, M., Arslan, D. and Ilhan, O. (2001) Effects of DMSO on platelet functions and P-selectin expression during storage. Transfus. Apher. Sci. 24, 261-267.
10. Chang, C.K., Llanes, S. and Schumer, W. (1999) Inhibitory effect of dimethyl sulfoxide on nuclear factor-kappa B activation and intercellular adhesion molecule 1 gene expression in septic rats. J. Surg. Res. 82, 294-299.
11. Dabareiner, R.M., White, N.A., Snyder, J.R., Feldman, B.F. and Donaldson, L.L. (2005) Effects of Carolina rinse solution, dimethyl sulfoxide, and the 21-aminosteroid, U-74389G, on microvascular permeability and morphology of the equine jejunum after low-flow ischemia and reperfusion. Am. J. vet. Res. 66, 525-536.
12. DeForge, L.E., Fantone, J.C., Kenney, J.S. and Remick, D.G. (1992) Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood. J. clin. Invest. 90, 2123-2129.
13. Essani, N.A., Fisher, M.A. and Jaeschke, H. (1997) Inhibition of NF-kappa B activation by dimethyl sulfoxide correlates with suppression of TNF-alpha formation, reduced ICAM-1 gene transcription, and protection against endotoxin-induced liver injury. Shock 7, 90-96.
14. Hammond, R.A., Hannon, R., Frean, S.P., Armstrong, S.J., Flower, R.J. and Bryant, C.E. (1999) Endotoxin induction of nitric oxide synthase and cyclooxygenase-2 in equine alveolar macrophages. Am. J. vet. Res. 60, 426-431.
15. Horne, M.M., Pascoe, P.J., Ducharme, N.G., Barker, I.K. and Grovum, W.L. (1994) Attempts to modify reperfusion injury of equine jejunal mucosa using dimethylsulfoxide, allopurinol, and intraluminal oxygen. Vet. Surg. 23, 241-249.
16. Longworth, K.E., Smith, B.L., Staub, N.C., Steffey, E.P. and Serikov, V.B. (1996) Use of detergent to prevent initial responses to endotoxin in horses. Am. J. vet. Res. 57, 1063-1066.
17. Moore, J.N., Norton, N., Barton, M.H., Hurley, D.J., Reber, A.J., Donovan, D.C., Vandenplas, M.L., Parker, T.S. and Levine, D.M. (2007) Rapid infusion of a phospholipid emulsion attenuates the effects of endotoxaemia in horses. Equine vet. J. 39, 243-248.
18. Moore, R.M., Muir, W.W., Bertone, A.L., Beard, W.L. and Stromberg, P.C. (1995) Effects of dimethyl sulfoxide, allopurinol, 21-aminosteroid U-74389G, and manganese chloride on low-flow ischemia and reperfusion of the large colon in horses. Am. J. vet. Res. 56, 671-687.
19. Murphey, E.D. and Traber, D.L. (2000) Pretreatment with tumor necrosis factor-alpha attenuates arterial hypotension and mortality induced by endotoxin in pigs. Crit. Care Med. 28, 2015-2021.
20. Opal, S.M. and Yu, R.L., Jr. (1998) Antiendotoxin strategies for the prevention and treatment of septic shock. New approaches and future directions. Drugs 55, 497-508.
21. Reeves, M.J., Vansteenhouse, J., Stashak, T.S., Yovich, J.V. and Cockerell, G. (1990) Failure to demonstrate reperfusion injury following ischaemia of the equine large colon using dimethyl sulphoxide. Equine vet. J. 22, 126-132.
22. Rosenblum, W. (1983) Dimethyl sulfoxide effects on platelet aggregation and vascular reactivity in pial microcirculation. Ann. N.Y. Acad. Sci. 411, 110-119.
23. Schleining, J.A. and Reinertson, E.L. (2007) Evidence for dimethyl sulphoxide (DMSO) use in horses. Part 2: DMSO as a parenteral anti-inflammatory agent and as a pharmacological carrier. Equine vet. Educ. 19, 598-599.
24. Sekizuka, E., Benoit, J.N., Grisham, M.B. and Granger, D.N. (1989) Dimethylsulfoxide prevents chemoattractant-induced leukocyte adherence. Am. J. Physiol. 256, H594-597.
25. Semrad, S.D. (1993) Comparison of flunixin, prednisolone, dimethyl sulfoxide, and a lazaroid (U74389F) for treating endotoxemic neonatal calves. Am. J. vet. Res. 54, 1517-1522.
26. Shuster, R., Traub-Dargatz, J. and Baxter, G. (1997) Survey of diplomates of the American College of Veterinary Internal Medicine and the American College of Veterinary Surgeons regarding clinical aspects and treatment of endotoxemia in horses. J. Am. vet. med. Ass. 210, 87-92.
27. Sullins, K.E., White, N.A., Lundin, C.S., Dabareiner, R. and Gaulin, G. (2004) Prevention of ischaemia-induced small intestinal adhesions in foals. Equine vet. J. 36, 370-375.
28. Sykes, B.W. and Furr, M.O. (2005) Equine endotoxaemia - a state-of-the-art review of therapy. Aust. vet. J. 83, 45-50.
29. Werners, A.H., Bull, S. and Fink-Gremmels, J. (2005) Endotoxaemia: a review with implications for the horse. Equine vet. J. 37, 371-383.
30. Winchell, W.W., Hardy, J., Levine, D.M., Parker, T.S., Gordon, B.R. and Saal, S.D. (2002) Effect of administration of a phospholipid emulsion on the initial response of horses administered endotoxin. Am. J. vet. Res. 63, 1370-1378.