Synthesis, antitubercular, antifungal and antibacterial activities of 6-substituted phenyl-2-(3′-substituted phenyl pyridazin-6′-yl)-2,3, 4,5-tetrahydropyridazin-3-one

Acta Poloniae Pharmaceutica - Drug Research

Volumn 65, Issue 3, 2008, Pages 353-362

  Islam, Mojahidul ^a   Siddiqui, Anees A ^a   Rajesh, Ramadoss ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Antibacterial activity; Antifungal; In vitro antitubercular; Pyridazine derivatives

Indexed keywords

6 (2''',4''' DIMETHYLPHENYL) 2 [3' (4' TOLYL)PYRIDAZIN 6' YL] 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 (2'',4'' DIMETHYL) 2 (3' PHENYLPYRIDAZIN 6' YL) 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 (2'',4''' DIMETHYL) 2 [3' (6'' METHOXYNAPHTHYL)PYRIDAZIN 6' YL] 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 (4' BIPHENYL) 2 (3' PHENYLPYRIDAZIN 6' YL) 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 (4' BIPHENYL) 2 [3' (4' BIPHENYL)PYRIDAZIN 6' YL] 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 (4' BIPHENYL) 2 [3' (4' TOLYL)PYRIDAZIN 6' YL)] 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 (4' BROMOPHENYL) 2 [3' (4' TOLYL)PYRIDAZIN 6' YL] 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 (4'' BROMOPHENYL) 2 (3' PHENYLPYRIDAZIN 6' YL) 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 (4'' CHLOROPHENYL 2 (3' PHENYLPYRIDAZIN 6 YL) 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 (4''' BIPHENYL) 2 [3' (2'',4'' DIMETHYLPHENYL)PYRIDAZIN 6' YL] 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 (4''' CHLOROPHENYL) 2 [3' (2'',4'' DIMETHYLPHENYL)PYRIDAZIN 6' YL] 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 (4''' CHLOROPHENYL) 2 [3' (6'' METHOXYNAPHTHYL)PYRIDAZIN 6' YL] 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 (4''' TOLYL) 2 [3' (4'' BIPHENYL)PYRIDAZIN 6' YL] 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 (5''' METHOXYNAPHTHYL) 2 [3' (4'' BIPHENYL)PYRIDAZIN 6' YL] 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 PHENYL 2 (3' PHENYLPYRIDAZIN 6' YL) 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 PHENYL 2 [3' (2'',4'' DIMETHYLPHENYL)PYRIDAZIN 6' YL] 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 PHENYL 2 [3' (4'' TOLYL)PYRIDAZIN 6' YL] 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; 6 PHENYL 2 [3' (6'' METHOXYNAPHTHYL)PYRIDAZIN 6' YL] 2,3,4,5 TETRAHYDROPYRIDAZIN 3 ONE; ALUMINUM CHLORIDE; AROMATIC HYDROCARBON; CLARITHROMYCIN; ETHIONAMIDE; GENTAMICIN; ISONIAZID; PHOSPHORUS DERIVATIVE; PROPIONIC ACID; PYRIDAZINE DERIVATIVE; RIFAMPICIN; TOBRAMYCIN; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; HEATING; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; ANTITUBERCULAR AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; PYRIDAZINES; REFERENCE STANDARDS; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 45849117579     PISSN: 00016837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Junge L.N., Boyd D.B., Alborn W.E.: J. Med. Chem. 34, 172 (1991).
2. Patel H.K., Fernandes P.S.: Ind. J. Chem. 88, 733 (1989).
3. Katrusiak A., Katrusiak A., Ba?oniak S.: Tetrahedron. 50, 12933 (1994).
4. Kraiso V.G., Goal A., Haider N., Matyus P.: J. Mol. Struct. (Theochem) 3, 528 (2000).
5. Livermone D.G.H., Bethell R.C., Cammack N.: J. Med. Chem. 36, 3784 (1993).
6. Siddiqui A.A., Shehroz M.M., Amir M.: Oriental J. Chem. 20, 303 (2004).
7. Rubat C., Coudert P., Refouvelet, B., Tronche, P., Bashde P., Bastide J.: Chem. Pharm. Bull. 38, 3009 (1990).
8. Seki T., Nakao T., Masuda T., Hasumi K., Gotanda K., Yasuda K.: Chem. Pharm. Bull. 44, 2061 (1996).
9. Cignarella G., Barlocco D., Pinna G.A.: J. Med. Chem. 32, 2277 (1989).
10. Vega A.M., Aldana I., Font M.: J. Pharm. Sci. 71, 1406 (1989).
11. Longo J.G., Verde I., Castro M.E.: J. Pharm. Sci. 82, 286 (1993).
12. Siddiqui A.A., Wani S.M., Ind. J. Chem. 43B, 1574 (2004).
13. Nagai H., Suda H., Iwama T., Daikoku M., Yanagihara Y., Khoda A.: Int. Arch. Allergy Immunol. 98, 57 (1992).
14. Suda H., Nagai H., Iwama T., Khoda A.: Int. Arch. Allergy Immunol. 97, 187 (1992).
15. Iwama T., Nagai H., Khoda A.: J. Pharm. Pharmacol. 45, 335 (2001).
16. Bebot M., Coudert P., Rubat C.: Chem. Pharm. Bull. 45, 659 (1997).
17. Pieretti S., Dal V., Malucci R., Giovannoni M. P., Galli A.: Life Sci. 65, 1381 (1999).
18. Inderland C.B., Nash K.A., Lorian V., Antibiotics in Laboratory Medicine, 4th ed., p.127, Williams and Wilkins, Baltimore 1996.
19. Inderland C.B., Salfinger M., Murray P.R., Baron E., Pfaller M.A., Tenover F.C., Yoken R.H.: Manual of Clinical Microbiology, 6th ed., p. 1385, ASM Press, Washington D.C.1995.
20. Greenwood D., Slack R.C.B., Peutherer J. F., Microbiology, 14th ed., p.1, Churchill and Livingstone, Spencerswood 1992.
21. Indian Pharmacopoeia., 3rd ed, p. 90, Govt. of India, New Delhi 1985. Acta Poloniae Pharmaceutica ñ Drug Research, Vol. 65 No. 3 pp. 363ñ370, 2008