Molecular vasis of α-thalassemia in Algeria

Hemoglobin

Volumn 32, Issue 3, 2008, Pages 273-278

  Mesbah Amroun, Hamida ^a,b   Rouabhi, Fatiha ^c   Ducrocq, Rolande ^b   Elion, Jacques ^b,d  

^a UNIVERSITY OF SCIENCES AND TECHNOLOGY HOUARI BOUMEDIENE   (Algeria)

^b HÔPITAL ROBERT DEBRÉ   (France)

^c CHU Mustapha   (Algeria)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Thalassemia ( thal); Algeria; Hb H; Mutation; Spectrum

Indexed keywords

BETA GLOBIN; HEMOGLOBIN H; GLOBIN;

ALGERIA; ALLELE; ALPHA THALASSEMIA; ANTHROPOLOGY; ARTICLE; BIOCHEMISTRY; BLOOD DONOR; CONTROLLED STUDY; EVALUATION; GENE FREQUENCY; HEMATOLOGY; HUMAN; IMAGE INTENSIFIER; MAJOR CLINICAL STUDY; RANDOM SAMPLE; EPIDEMIOLOGY; FEMALE; GENETICS; MALE; METHODOLOGY; MUTATION;

ALGERIA; ALLELES; ALPHA-THALASSEMIA; BLOOD DONORS; EPIDEMIOLOGY, MOLECULAR; FEMALE; GENE FREQUENCY; GLOBINS; HUMANS; MALE; MUTATION;

EID: 45849108036     PISSN: 03630269     EISSN: 1532432X     Source Type: Journal    
DOI: 10.1080/03630260802004301     Document Type: Article

References (22)

1. Trabuchet G, Belhani M, Richard F, Hamladji RM, Benabadji M, Colonna P. Premières observations d'alpha thalassemie en Algérie: 12 cas d'hémoglobinose H. Sem Hôp Paris, 1977; 53(16):885-889.
2. Henni T, Bachir D, Tabone P, Jurdic P, Godet J, Colonna P. Hemoglobin Bart's in Northern Algeria. Acta Haematologica 1981; 65(4):240-246.
3. Henni T, Morlé F, Lopez B, Colonna P, Godet J. α-Thalassemia haplotypes in the Algerian population. Hum Genet 1987; 75(3):272-276.
4. Iα in the same Algerian family. Hum Mutat 1995; 5(2):182-183.
5. Kattamis C, Camaschella C, Sivera P, Surrey S, Fortina P. Human α-thalassemia syndromes: detection of molecular defects. Am J Hematol 1996; 53(2):81-91.
6. Baysal E, Huisman THJ. Detection of common deletional α-thalassemia-2 determinants by PCR. Am J Hematol 1994; 46(3):208-213.
7. Bowden DK, Vickers MA, Higgs DR. A PCR-based strategy to detect the common severe determinants of α thalassaemia. Br J Haematol 1992; 81(1):104-118.
8. Treager-Synodinos J, Kanavakis E, Tsezis M, Kattamis A, Kattamis C. Characterization of nondeletional α thalassemia mutations in the Greek population. Am J Hematol 1993; 44(3):162-167.
9. T-Saudi (AATAAA→AATAAG) in the α2-globin gene. Hemoglobin 1999; 23(3):213-220.
10. Mirabile E, Samperi P, Di Catalo A, Poli A, La Spina M, Schiliro G. Phenotype-genotype correlation in Sicilian patients with Hb H. J Eur Haematol 2000; 65(5):306-309.
11. Peres MJ, Romão L, Carreiro H, Picanço I, Batalha L, Magalhães HA, Martins MC, Lavinha J. Molecular basis of α-thalassemia in Portugal. Hemoglobin 1995; 19(6):343-352.
12. Pirastu M, Lee KY, Dozy AM, Kan YW, Stamatoyannopoulos G, Hadjiminas MG, Zachariades Z, Angius A, Furbetta M, Rosatelli C, Cao A. α-Thalassemia in two Mediterranean populations. Blood 1982; 60(2):509-512.
13. Harteveld KL, Heister AJGAM, Giordano PC, Losekoot M, Bernini LF. Rapid detection of point mutations and polymorphisms of the α-globin genes by DGGE and SSCA. Hum Mutat 1996; 7(2):114-122.
14. Zorai A, Harteveld CL, Bakir A, van Delft P, Falfoul A, Dellagi K, Abbes S, Giordano PC. Molecular spectrum of α-thalassemia in Tunisia: epidemiology and detection at birth. Hemoglobin 2002; 26(4):353-362.
15. Bachir D, Belhani M, Godet J, Nigon V, Colonna P. Indirect evaluation of a gene frequency: calculation of β-thalassemia frequency in Algeria based on associated hemoglobin variants frequency. Hum Hered, 1984; 34(3):187-191.
16. Higgs DR, Vickers MA, Wilkie AOM, Pretorius I-M, Jarman AP, Weatherall DJ. A review of the molecular genetics of the human α-globin gene cluster. Blood 1989; 73(5):1081-1104.
17. Fichera M Spalletta A, Fiorenza F, Lombardo T, Schiliro G, Tamouza R, Lapoumeroulie C, Labie D, Ragusa A. Molecular basis of α-thalassemia in Sicily. Hum Genet 1997; 99(3):381-386.
18. Zorai A, Abbes S, Préhu C, Omar S, Gerard N, Hafsia R, Asma B, Guemira F, Dellagi K. Hb H disease among Tunisians: molecular characterization of α-thalassemia determinants and hematological findings. Hemoglobin 2003; 27(1):57-61.
19. Pressley L, Higgs DR, Clegg JB, Perrine RP, Pembrey ME, Weatherall DJ. A new genetic basis for Hemoglobin H disease. N Engl J Med, 1980; 303(24): 1383-1388.
20. Thein SL, Wallace RB, Pressley L, Clegg JB, Weathrall DJ, Higgs DR. The polyadenylation site mutation in the α-globin gene cluster. Blood 1988; 71(2):313-319.
21. Bernini LF. Geographic distribution of α-thalassemia. In: Steinberg MH, ed. Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management. Cambridge: Cambridge University Press. 2001; 878-894.
22. Labie D, Benabadji M, Elion J. Genetic disorders in North African populations of the Maghreb. In: Teebi AS, Farag TI, eds. Genetic Disorders Among Arab Populations. New York: Oxford University Press. 1997; 290-321.