Statistical issues of QT prolongation assessment based on linear concentration modeling

Journal of Biopharmaceutical Statistics

Volumn 18, Issue 3, 2008, Pages 564-584

  Tsong, Yi ^a,b   Shen, Meiyu ^a   Zhong, Jinglin ^a   Zhang, Joanne ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Bias; Concentration response relationship; Linear model; Underestimate

Indexed keywords

MOXIFLOXACIN; PLACEBO; ANTIINFECTIVE AGENT; HETEROCYCLIC COMPOUND; QUINOLINE DERIVATIVE;

ANALYTIC METHOD; ARTICLE; DATA ANALYSIS; DRUG RESEARCH; LINEAR CONCENTRATION MODEL; METHODOLOGY; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; STATISTICAL MODEL; VALIDATION PROCESS; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ELECTROCARDIOGRAPHY; HEART RATE; HUMAN; INTERNATIONAL COOPERATION; LONG QT SYNDROME; PATHOPHYSIOLOGY; PHYSIOLOGY; PRACTICE GUIDELINE; RANDOMIZED CONTROLLED TRIAL; SAMPLE SIZE; STANDARD; STATISTICS; TIME;

ANTI-INFECTIVE AGENTS; AZA COMPOUNDS; ELECTROCARDIOGRAPHY; GUIDELINES AS TOPIC; HEART RATE; HUMANS; INTERNATIONAL COOPERATION; LINEAR MODELS; LONG QT SYNDROME; QUINOLINES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SAMPLE SIZE; TIME FACTORS;

EID: 45849091900     PISSN: 10543406     EISSN: 15205711     Source Type: Journal    
DOI: 10.1080/10543400801995502     Document Type: Article

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