Nasal treatment with a microemulsion reduces allergen challenge-induced symptoms and signs of allergic rhinitis

Acta Oto-Laryngologica

Volumn 128, Issue 6, 2008, Pages 666-669

  Andersson, Morgan ^a   Greiff, Lennart ^a   Wollmer, Per ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Airway; Inflammation; Plasma exudation; Rhinitis

Indexed keywords

ALLERGEN; ALPHA 2 MACROGLOBULIN; GLYCEROL OLEATE; LIPID; MACROGOL 400; PLACEBO; POLYSORBATE 80; PROPYLENE GLYCOL; SESAME SEED OIL; SODIUM CHLORIDE;

ADULT; ALLERGIC RHINITIS; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEVICE; FEMALE; HUMAN; LIPID COMPOSITION; MALE; MICROEMULSION; NOSE MUCUS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROVOCATION TEST; SCORING SYSTEM; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; SYMPTOM;

ADMINISTRATION, INTRANASAL; ADULT; ALLERGENS; ALPHA-MACROGLOBULINS; DESENSITIZATION, IMMUNOLOGIC; EMULSIONS; FEMALE; HUMANS; MALE; NASAL LAVAGE FLUID; POLLEN; RHINITIS, ALLERGIC, SEASONAL; SINGLE-BLIND METHOD;

EID: 45849086933     PISSN: 00016489     EISSN: 16512553     Source Type: Journal    
DOI: 10.1080/00016480701642197     Document Type: Article

References (16)

1. Linneberg A, Henrik-Nielsen N, Frølund L, Madsen F, Dirksen A, Jørgensen T. The link between allergic rhinitis and allergic asthma: a prospective population-based study. The Copenhagen Allergy Study. Allergy 2002;57:1048-52.
2. Bousquet J, Van Cauwenberger P, Bachert C, Canonica GW, Demoly P, Durham SR, et al. Requirements for medication commonly used in the treatment of allergic rhinitis. European Academy of Allergy and Clinical Immunology (EAACI), Allergic Rhinitis and its Impact on Asthma (ARIA). Allergy 2003;58:192-7.
3. Donnelly AL, Glass M, Minkwitz MC, Casale TB. The leukotriene D4-receptor antagonist, ICI 204, 219, relieves symptoms of acute seasonal allergic rhinitis. Am J Respir Crit Care Med 1995;151:1734-9.
4. Casale TB. Anti-immunoglobulin E (omalizumab) therapy in seasonal allergic rhinitis. Am J Respir Crit Care Med 2001;164:S18-21.
5. Persson CGA, Erjefält JS, Greiff L, Andersson M, Erjefält I, Godfrey RW, et al. Plasma-derived proteins in airway defence, disease and repair of epithelial injury. Eur Respir J 1998;11:958-70.
6. Greiff L, Andersson M, Persson CGA. Nasal secretions/ exudations: collection and approaches to analysis. In: Rodgers D, Donnelly L, editors. Methods in molecular medicine. Totowa: Humana Press, 2001:61-73.
7. Wilson DR, Nouri-Aia KT, Walker SM, Pajno GB, O'Brien F, Jacobson MR, et al. Grass pollen immunotherapy: symptomatic improvement correlates with reductions in eosinophils and IL-5 mRNA expression in the nasal mucosa during the pollen season. J Allergy Clin Immunol 2001;107:971-6.
8. Allergic rhinitis: clinical development programs for drug products. In: Guidance for the industry. Department of Health and Human Services Food and Drug Administration Centre for Drug Evaluation and Research (CDER), 2000 April. Available from: http:/www.fda.gov/cder/guidance/2718dtf.htm
9. Greiff L, Persson CGA, Svensson C, Enander I, Andersson M. Loratadine reduces allergen-induced mucosal output of a2-macroglobulin and tryptase in allergic rhinitis. J Allergy Clin Immunol 1995;96:97-103.
10. Altman DG. Practical statistics for medical research. London: Chapman & Hall; 1997. p. 455-60.
11. The European Pharmacopoeia, 5th edn. Available from: http:/www.edqm.eu/ site/page_581.php
12. Linden M, Svensson C, Andersson E, Andersson M, Greiff L, Persson CGA. Immediate effect of topical budesonide on allergen challenge-induced nasal mucosal fluid levels of granulocyte-macrophage colony-stimulating factor and interleukin-5. Am J Respir Crit Care Med 2000;162:1705-8.
13. Spickard A 3rd, Hirschmann JV. Exogenous lipid pneumonia. Arch Intern Med 1994;154:686-92.
14. Lipid pneumonia due to Mexican folk remedies. Arch Pediatr Adolesc Med 2005;149:1043-8.
15. Wolters-Arts M, Lush WM, Mariani C. Lipids are required for directional pollen-tube growth. Nature 1998;392:818-21.
16. Bufe A. A simple advice for the prevention of pollen-induced allergic rhinitis. Int Arch Allergy Immunol 2000;121:85-6.