α1,4GlcNAc-capped mucin-type O-glycan inhibits cholesterol α-glucosyltransferase from Helicobacter pylori and suppresses H. pylori growth

Glycobiology

Volumn 18, Issue 7, 2008, Pages 549-558

  Lee, Heeseob ^a,c   Wang, Ping ^a   Hoshino, Hitomi ^b   Ito, Yuki ^a   Kobayashi, Motohiro ^b   Nakayama, Jun ^b   Seeberger, Peter H ^a,d   Fukuda, Minoru ^a  

^a BURNHAM INSTITUTE   (United States)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Pusan National University   (South Korea)

^d ETH ZURICH   (Switzerland)

Author keywords

4GlcNAc capped core 2 branched O glycan; Cholesterol glucosyltransferase; Growth inhibition; Helicobacter pylori; Novel antibiotics

Indexed keywords

CHOLESTEROL; CHOLESTEROL ALPHA GLUCOSYLTRANSFERASE; GENOMIC DNA; GLUCOSYLTRANSFERASE; GLYCAN DERIVATIVE; MONOSACCHARIDE; MUCIN; N ACETYLGLUCOSAMINE; OLIGOSACCHARIDE; URIDINE DIPHOSPHATE GLUCOSE; DRUG DERIVATIVE; HP0421 PROTEIN, HELICOBACTER PYLORI; POLYSACCHARIDE; RECOMBINANT PROTEIN;

ARTICLE; BACTERIAL CELL WALL; BACTERIAL GROWTH; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG INDICATION; DRUG SYNTHESIS; ENZYME ANALYSIS; ENZYME INHIBITION; ESCHERICHIA COLI; GROWTH INHIBITION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; DRUG ANTAGONISM; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; METABOLISM; SOLUBILITY;

ESCHERICHIA COLI; HELICOBACTER PYLORI;

ACETYLGLUCOSAMINE; CHOLESTEROL; ESCHERICHIA COLI; GLUCOSYLTRANSFERASES; HELICOBACTER PYLORI; OLIGOSACCHARIDES; POLYSACCHARIDES; RECOMBINANT PROTEINS; SOLUBILITY; URIDINE DIPHOSPHATE GLUCOSE;

EID: 45749138417     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwn037     Document Type: Article

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