Induction of SiHa cells apoptosis by nanometer realgar suspension and its mechanism

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 28, Issue 3, 2008, Pages 317-321

  Liu, Rong ^a,b   Pu, Demin ^a   Liu, Yan ^b   Cheng, Yanxiang ^a   Yin, Ling ^a   Li, Tian ^a   Zhao, Libo ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b No 457 Hospital of PLA   (China)

Author keywords

Apoptosis; E6 gene; E7 gene; Human papilloma virus 16; Nanometer realgar suspension; SiHa cells

Indexed keywords

ARSENIC DISULFIDE; DNA; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 16; ONCOGENE PROTEIN E7, HUMAN PAPILLOMAVIRUS TYPE 16; ONCOPROTEIN; ORGANOARSENIC DERIVATIVE; REPRESSOR PROTEIN; SULFIDE; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

APOPTOSIS; ARTICLE; CHEMISTRY; DOSE RESPONSE; FEMALE; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; METHODOLOGY; NANOTECHNOLOGY; TIME; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; UTERINE CERVIX TUMOR;

APOPTOSIS; ARSENICALS; CELL LINE, TUMOR; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOTECHNOLOGY; ONCOGENE PROTEINS, VIRAL; REPRESSOR PROTEINS; SULFIDES; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS; UTERINE CERVICAL NEOPLASMS;

EID: 45749134687     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-008-0320-5     Document Type: Article

References (11)

1. Huang N J, Xie Q Y, Luo L J. Determination of trace arsenic content in Jiu Ji Xing Jun capsules by UV spectrophotometry. Chin Tradi Potent Med (Chinese), 2005,27(7):772-774
2. Xu H, Chen Y H, Chen A X et al. Preparation of complex realgar creamor and clinical potency observation. Chin Hosp Pharm J (Chinese), 2002,22(3):183-184
3. Wang X B, Xi R G, Zhang Z R et al. Study on pharmacokinetics of nanoparticle realgar powders in rabbit. Pharm J Chin PL, 2002,18(6):324-326
4. Ning N, Peng Z F, Yuan L et al. Realgar nano-particles induce apoptosis and necrosis in leukemia cell lines K562 and HL-60. Chin J Chin Materia Medica (Chinese), 2005,30(2):136-140
5. Zhan X Q, Zhao F M, Guo L W. A pharmacokinetics study of super micronized realgar particles and the comparison of neoplasma-suppressive effects. J Prac Tradi Chin Med (Chinese), 2006,22(7):397-399
6. Zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer, 2002,2(5):342-350
7. Nomine Y, Masson M, Charbonnier S et al. Structural and functional analysis of E6 oncoprotein: insights in the molecular pathways of human papillomavirus-mediated pathogenesis. Mol Cell, 2006,21(5):665-678
8. Ledwada T, Dlamini Z, Naicker S et al. Molecular genetics of human cervical cancer: role of papillomavirus and the apoptotic cascade. Biol Chem, 2004,385(8):671-682
9. Lu X N, Zheng J. The association of HeLa cell apoptosis induced by arsenic trioxide with the down-regulation of HPV18E6 oncogene and inhibition of telomerase activity. Chin J Oncol, 2005,27(5):265-268
10. Zheng J, Deng Y P, Lin C et al. Arsenic trioxide induces apoptosis of HPV-16DNA-immortalized human cervical epithelial cells and selectively inhibit viral gene expression. Int J Cancer, 1999,82(3):286-292
11. Um S J, Lee S Y, Kim E J et al. Down-regulation of human papillomavirus E6/E7 oncogene by arsenic trioxide in cervical carcinoma cells. Cancer Lett, 2002,181(1):11-22