Attenuation of vasospasm by dexmedetomidine after experimental subarachnoidal haemorrhage in rabbits

Turkish Journal of Medical Sciences

Volumn 38, Issue 3, 2008, Pages 191-197

  Eser, Olcay ^a,c   Fidan, Hüseyin ^a   Coşkun, Ömer ^b   Ela, Yüksel ^a   Songur, Ahmet ^a   Coşar, Murat ^a  

^a AFYON KOCATEPE UNIVERSITY   (Turkey)

^b TRAKYA UNIVERSITY   (Turkey)

^c NONE

Author keywords

Dexmedetomidine; Subarachnoid haemorrhage; Vasospasm

Indexed keywords

(+ MOD 2N) OPERATION; ANIMAL MODELS; BASILAR ARTERY; HAEMORRHAGE; INTRACRANIAL ANEURYSMS; INTRAVENOUS INFUSION; NEW ZEALAND RABBITS; PHYSIOLOGICAL SALINE SOLUTION; VASCULAR WALLS; WALL THICKNESSES;

DEXMEDETOMIDINE; SODIUM CHLORIDE; THIOPENTAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTERY OCCLUSION; ARTICLE; BASILAR ARTERY; BLOOD AUTOTRANSFUSION; BLOOD VESSEL WALL; CONTROLLED STUDY; DRUG EFFECT; DRUG INFUSION; HEART MUSCLE REVASCULARIZATION; MALE; NONHUMAN; RABBIT; SUBARACHNOID HEMORRHAGE; VASOSPASM;

EID: 45749111087     PISSN: 13000144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Wilkins RH. Attempted prevention or treatment of intracranial arterial spasm: a survey. Neurosurgery 1980; 6:198-210.
2. Atalay B, Bolay H, Dalkara T. Transcorneal stimulation of trigeminal nerve afferents to increase cerebral blood flow in rats with cerebral vasospasm: a non invasive method to activate the trigeminovascular reflex. J Neurosurg 2002; 97: 1179-1183.
3. Aydin IH, Onder A. The effect of very early cisternal irrigatio on basilar artery spasm SAH in rat model. Acta Neurochir (Wien) 1991; 113: 69-73.
4. Bagirici F, Bostanci MO. Anticonvulsive effects of nimodipine on penicillin-induced epileptiform activity. Acta Neurobiol Exp (Wars) 2006; 66 (2): 123-128.
5. Kemaloglu S, Ozkan U, Yilmaz F. Preventive effects of intracisternal alphatocopherol on cerebral vasospasm in experimental subarachnoid haemorrhage. Yonsei Med J 2003; 44: 955-960.
6. Mayberg MR, Okada T, Bark HD. The significance of morphological changes in cerebral arteries after subarachnoid haemorrhage. J Neurosug 1990; 72: 626-633.
7. Munoz-Castaneda JR, Montilla P, Padillo FJ, Bujalance I, Munoz MC, Muntane J, Tunez I . Role of serotonin in cerebral oxidative stress in rats. Acta Neurobiol Exp (Wars) 2006; 66 (1): 1-6.
8. Naredi S, Lambert G, Eden E. Increased sympathetic nervous activity in patients with nontraumatic subarachnoid hemorrhage. Stroke 2000; 31: 901-906.
9. Hoffman WE, Kochs E, Werner C. Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Anesthesiology 1991; 75: 328-332.
10. Maeir C, Steinberg GK, Sun GH. Neuroprotection by the α-2 adrenoceptor agonist dexmedetomidine in a focal model of cerebral ischemia. Anesthesiology 1993; 79: 1-7.
11. Kuhmonen J, Pokorny J, Miettinen R. Neuroprotective effects of of dexmedetomidine in the gerbil hippocampus following transient global ischemia. Anesthesiology 1997; 87: 371-377.
12. Karlsson BR, Loberg EM, Steen PA. Dexmedetomidine, a potent α2-agonist, does not affect neuronal damage following severe forebrain ischemia in the rat. Eur J Anesthesiol 1995; 12:281-285.
13. Bunc G, Kovacic S, Strnad S. Attenuation of cerebral vasospasm in rabbits using clonidine hydrochloride, a central adrenergic agonist. Autonomic Neuroscience: Basic and Clinical 2003; 105: 71-76.
14. Matsumoto M, Zornow MH, Rabin BC, Maze M. The α-adrenergic agonist, dexmedetomidine, selectively attenuates is-2 chemia-induced increases in striatal norepinephrine concentrations. Brain Res 1993; 627: 325-329.
15. Peerless SJ, Yasargil MG. Adrenergic innervation of the cerebral blood vessels in the rabbit. J Neurosurg 1971; 35: 148-154.
16. Solomon RA, Antunes JL, Chen RYZ. Decrease in cerebral blood flow in rats after experimental subarachnoid heamorrhage: A new model. Stoke 1985;16: 58-64.
17. 2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia. Eur J Pharm 1999; 372: 31-36.
18. Lobato RD, Marin J, Salaices M. Cerebrovascular reactivity to noradrenaline and serotonin following experimental subarachnoid hemorrhage. J Neurosurg 1980; 53: 480-485.
19. Minegishi A, Ishizaki T, Yoshida Y. Plasma monoaminergic metabolites and catecholamines in subarachnoid hemorrhage: Clinical implications. Arch Neurol 1987; 44: 423-428.
20. Hamann G, Haass A, Schimrigk K. Beta-blockade in acute aeurysmal subarachnoid hemorrhage. Acta Neurochir 1993; 121: 119-122.
21. Bunc G, Kovacic S, Strnad S. Sympathetic nervous system exclusion following experimental subarachnoid haemorrhage prevents vasospasm in rabbits. Wien Klin Wochenschchr 2000; 112: 533-539.
22. Lambert G, Naredi S, Edin E. Sympathetic nervous activation following subarachnoid hemorrhage: Influence of intravenous clonidine Acta Anaesthesiol Scand 2002; 46: 160-165.
23. Tsukahara T, Taniguchi T, Usui H. Sympathetic denervation and alpha adrenoceptors in dog cerebral arteries. Naunyn Schmiedebergs Arch Pharmacol 1986; 334: 436-443.
24. Iida H, Iida M, Ohata H, Nagase K, Dosi H. Hypothermia Attenuates the Vasodilator Effects of Dexmedetomidine on Pial Vessels in Rabbits In Vivo. Anesth Analg 2004; 98: 477-482.
25. Zornow MH, Fleischer JE, Scheller MS. Dexmedetomidine, an alpha 2-adrenergic agonist, decreases cerebral blood flow in the isoflurane- anesthetized dog. Anesth Analg 1990; 70: 624-630.
26. Ohata H, Iida H, Dohi S. Intravenous dexmedetomidine inhibits cerebrovascular dilation induced by isoflurane and sevoflurane in dogs. Anesth Analg 1999; 89: 370-377.
27. Prielipp RC, Wall MH, Tobin JR. Dexmedetomidine-induced sedation in volunteers decreases regional and global cerebral blood flow. Anesth Analg 2002; 95: 1052-1059.
28. Bryan RM Jr, Eichler MY. Stimulation of alpha 2 adrenoceptors dilates the rat middle cerebral artery. Anesthesiology 1996; 85: 82-90.
29. Cooke JP. Does ADMA cause endothelial dysfunction? Arterioscler Thromb Vasc Biol 2000; 20: 2032-2037.
30. Kovacic S, Bunc G, Ravnik J. Correspondance between the time course of cerebral vasospam and the level of cerebral dopamine-α-hydroxylase in rabbits. Auton Neurosci 2006; 130: 28-31.