In vitro degradation and in vivo biocompatibility study of a new linear poly(urethane urea)

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 86, Issue 1, 2008, Pages 45-55

  Asplund, Basse ^a   Aulin, Cecilia ^a   Bowden, Tim ^a   Eriksson, Niklas ^b   Mathisen, Torbjörn ^b   Bjursten, Lars Magnus ^c   Hilborn, Jöns ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b Radi Medical Systems AB   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Biodegradable; Hydrolysis; LDI; Mechanical properties; Polyurethane

Indexed keywords

ADDITION REACTIONS; ANIMAL CELL CULTURE; BIOCOMPATIBILITY; BIODEGRADATION; CELL CULTURE; COBALT; COBALT ALLOYS; COBALT COMPOUNDS; DEGRADATION; GAMMA RAYS; HYDROLYSIS; INDUSTRIAL ECONOMICS; MECHANICAL PROPERTIES; METABOLISM; MICROFLUIDICS; PIGMENTS; RATE CONSTANTS; STRAIN HARDENING; SULFATE MINERALS; TENSILE STRAIN; TENSILE STRENGTH; THERMODYNAMIC PROPERTIES; UREA;

(PL) PROPERTIES; CELL-VIABILITY; CHAIN EXTENDER (CE); DEGRADATION RATES; ELONGATION AT BREAK (EB); FOREIGN BODY REACTION (FBR); HARD SEGMENTS; HIGH STRAINS; HUMAN FIBROBLASTS; IN VITRO DEGRADATION; IN-VIVO; INHERENT VISCOSITY; INITIAL LOSSES; LINEAR POLY(SULFONE AMINES); SEGMENTED POLY(ESTER URETHANE); SOFT SEGMENTS; STRENGTH (IGC: D5/D6);

MATERIALS PROPERTIES;

ALICYCLIC HYDROCARBON; CARBONYL DERIVATIVE; LACTIC ACID; LACTONE DERIVATIVE; POLYMER; POLYURETHAN UREA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CELL VIABILITY; CYTOTOXICITY TEST; DEGRADATION; FIBROBLAST CULTURE; GAMMA RADIATION; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MATERIALS TESTING; NONHUMAN; POLYMER PRODUCTION; RAT; STRESS STRAIN RELATIONSHIP; TENSILE STRENGTH; THERMAL ANALYSIS; VISCOSITY;

ANIMALS; BIOCOMPATIBLE MATERIALS; FIBROBLASTS; HOT TEMPERATURE; HUMANS; HYDROLYSIS; MALE; MATERIALS TESTING; POLYURETHANES; RATS; RATS, SPRAGUE-DAWLEY; STRESS, MECHANICAL; TENSILE STRENGTH; UREA;

EID: 45749096962     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.30986     Document Type: Article

References (31)

1. Ratner B, Hoffman A, Schoen F, Lemons J. Biomaterials science. In: Ratner B, Hoffman A, Schoen F, Lemons J, editors. An Introduction to Materials in Medicine, 2nd Ed. London: Elsevier; 2004. p117.
2. Zhang JY, Beckman EJ, Piesco NP, Agarwal SA. New peptide-based urethane polymer: Synthesis, biodegradation, and potential to support cell growth in vitro. Biomaterials 2000;21:1247-1258.
3. Gisselfält K, Edberg B, Flodin P. Synthesis and properties of degradable poly(urethane urea)s to be used for ligament reconstructions. Biomacromolecules 2002;3:951-958.
4. Riboldi SA, Sampaolesi M, Neuenschwander P, Cossu G, Mantero S. Electrospun degradable polyesterurethane membranes: potential scaffolds for skeletal muscle tissue engineering. Biomaterials 2002;26:4606-4615.
5. Guan J, Sacks MS, Beckman EJ, Wagner WR. Synthesis, characterization, and cytocompatibility of elastomeric, biodegradable poly(ester-urethane)ureas based on poly(caprolactone) and putrescine. J Biomed Mater Res 2002;61:493-503.
6. Heijkants RGJC, van Calck RV, van Tienen TG, de Groot JH, Buma P, Pennings AJ, Veth RPH, Scheuten AJ. Uncatalyzed synthesis, thermal and mechanical properties of polyurethanes based on poly(ε-caprolactone) and 1,4-butane diisocyanate with uniform hard segment. Biomaterials 2005;26:4219-4228.
7. Yoshitake N, Furukawa M. Thermal degradation mechanism of α,γ-diphenyl alkyl allophanate as a model polyurethane by pyrolysis-high-resolution gas chromatography/FT-IR. J Anal Appl Pyrolysis 1995;33:269-281
8. Furukawa M, Yokoyama T. Study of thermal decomposition of diphenyl alkyl allophanates by direct pyrolysis mass spectroscopy. Polym Degrad Stabil 1990;29:341-352.
9. Tang YW, Labow RS, Santerre JP. Isolation of methylene dianiline and aqueous-soluble biodegradation products from polycarbonate-polyurethanes. Biomaterials 2003;24:2805-2819.
10. Asplund B, Bowden T, Mathisen T, Hilborn J. Variable hard segment length in poly(urethane urea) through excess of diisocyanate and vapor phase addition of water. Macromolecules 2006;39:4380-4385.
11. Asplund B, Bowden T, Mathisen T, Hilborn J. Synthesis of highly elastic biodegradable poly(urethane urea). Biomacromolecules 2007;8:905-911.
12. Zdrahala RJ, Zdrahala IJJ. Biomedical applications of polyurethanes: A review of past promises, present realities and a vibrant future. Biomat Appl 1999;14:67-90.
13. Pitt CG, Gratzl MM, Kimmel GL, Surles J, Schindler A. Aliphatic polyesters. II. The degradation of poly (D,L-lactide), poly (ε-caprolactone), and their copolymers in vivo. Biomaterials 1981;2:215-220.
14. Qing C, Jianzhong B, Shenguo W. Synthesis and degradation of a tri-component copolymer from glycolide, L-lactide, and ε-caprolactone. J Biomater Sci Polym Edn 2000;11:273-288.
15. Pêgo AP, Poot AA, Grijpma DW, Feijen J. In vitro degradation of trimethylene carbonate based (Co)polymers. Macromol Biosci 2002;2:411-419.
16. Pêgo AP, van Luyn MJA, Brouwer LA, van Wachem PB, Poot AA, Grijpma DW, Feijen J. In vivo behaviour of poly( 1,3-trimethylene carbonate) and copolymers of 1,3-trimethlyene carbonate with D,L-lactide or ε-caprolactone: Degradation and tissue response. J Biomed Mater Res A 2003;67:1044-1054.
17. Stokes K, McVenes R. Polyurethane elastomers biostability. J Biomat Appl 1995;9:321-354.
18. Chapman TM. Models for polyurethane hydrolysis under moderately acidic conditions: A comparative study of hydrolysis rates of urethanes, ureas, and amides. J Polym Sci Poly Chem 1989;27:1993-2005.
19. Storey RF, Hickey TP. Degradable polyurethane networks based on D,L-lactide, glycolide, ε-caprolactone, and trimethylene carbonate homopolyester and copolyester triols. Polymer 1994;35:830-838.
20. Tsuji H, Mizuno A, Ikada Y. Properties and morphology of poly(L-lactide), Part 3: Effects of initial crystallinity on long-term in vitro hydrolysis of high molecular weight poly(L-lactide) film in phosphate-buffered solution. J Appl Polym Sci 2000;77:1452-1464.
21. Asplund B, Sperens J, Mathisen T, Hilborn J. Effects of hydrolysis on a new biodegradable co-polymer. J Biomater Sci Polym Edn 2006;17:615-630.
22. Rosengren A, Danielsen N, Bjursten LM. Inflammatory reaction dependence on implant localization in rat soft tissue models. Biomaterials 1997;18:979-987.
23. Thomsen P, Bjursten LM, Ericson LE. Implants in the abdominal wall of the rat. Scand J Plast Reconstr Surg 1986;20:173-182.
24. Storey RF, Wiggins JS, Puckett AD. Hydrolyzable poly(ester urethane) networks from L-lysine diisocyanate and D,L-lactide/ε- caprolactone homo- and copolyester triols. J Polym Sci Poly Chem 1994;32:2345-2363.
25. Hiltunen K, Tuominen J, Seppälä JV. Hydrolysis of lactic acid based poly(ester-urethane)s. Polym Int 1998;47:186-192.
26. Watanabe E, Suzuki M, Nagata K, Kaneeda T, Harada Y, Utsumi M, Mori A, Moriya H. Oxidation-induced dynamic changes in morphology reflected on freeze-fractured surface of gamma-irradiated ultra-high molecular weight polyethylene components. J Biomed Mater Res 2002;62:540-549.
27. Albertsson A-C, Eklund M. Influence of molecular structure of the degradation mechanism of degradable polymers: In vitro degradation of poly(trimethylene carbonate), poly(trimethylene carbonate- co-caprolactone), and poly(adipic anhydride). J Appl Polym Sci 1995;57:87-103.
28. Abraham GA, Frontini PM, Cuadrado TR. Physical and mechanical behavior of sterilized biomedical segmented polyurethanes. J Appl Polym Sci 1997;65:1193-1203.
29. Gorna K, Gogolewski S. Molecular stability, mechanical properties, surface characteristics and sterility of biodegradable polyurethanes treated with low-temperature plasma. Polym Degrad Stabil 2003;79:465-474.
30. Nair PD, Sreenivasa K, Jayabalan M. Multiple gamma radiation sterilization of polyester fibers. Biomaterials 1988;9:335-338
31. Lendlein A, Colussi M, Neuenschwander P, Suter UW. Hydrolytic degradation of phase-segregated multiblock copoly (ester urethane)s containing weak links. Macromol Chem Phys 2001;202:2702-2711.