Risk of erectile dysfunction induced by arsenic exposure through well water consumption in Taiwan

Environmental Health Perspectives

Volumn 116, Issue 4, 2008, Pages 532-536

  Hsieh, Fang I ^a   Hwang, Ti Sheng ^b   Hsieh, Yi Chen ^a   Lo, Hsiu Chiung ^a   Su, Chien Tien ^a,c   Hsu, Hui Shing ^d   Chiou, Hung Yi ^a   Chen, Chien Jen ^e  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d LOTUNG POH AI HOSPITAL   (Taiwan)

^e GENOMICS RESEARCH CENTER   (Taiwan)

Author keywords

Arsenic exposure; Calculated free testosterone; Erectile dysfunction; Sex hormone; Total testosterone

Indexed keywords

ARSENIC; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; WELL WATER;

ADULT; AGED; ARSENIC POISONING; ARTICLE; CARDIOVASCULAR DISEASE; CIGARETTE SMOKING; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE SEVERITY; ENDEMIC DISEASE; ENVIRONMENTAL EXPOSURE; ERECTILE DYSFUNCTION; FLUID INTAKE; HEALTH BEHAVIOR; HORMONE DETERMINATION; HUMAN; HYPERTENSION; LONG TERM EXPOSURE; MAJOR CLINICAL STUDY; MALE; MEDICAL EXAMINATION; PREVALENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; QUESTIONNAIRE; RADIOIMMUNOASSAY; RISK ASSESSMENT; RISK FACTOR; TAIWAN; WATER CONTAMINATION;

AGED; ARSENIC; ENVIRONMENTAL EXPOSURE; ERECTILE DYSFUNCTION; HEALTH BEHAVIOR; HUMANS; MALE; MIDDLE AGED; PREVALENCE; RISK ASSESSMENT; TAIWAN; WATER POLLUTANTS, CHEMICAL; WATER SUPPLY;

EID: 45749085277     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.10930     Document Type: Article

References (44)

1. Ahn HS, Park CM, Lee SW. 2002. The clinical relevance of sex hormone levels and sexual activity in the ageing male. BJU Int 89:526-530.
2. Andersson KE, Wagner G. 1995. Physiology of penile erection. Physiol Rev 75:191-236.
3. Ansong KS, Lewis C, Jenkins P, Bell J. 2000. Epidemiology of erectile dysfunction: a community-based study in rural New York State. Ann Epidemiol 10:283-296.
4. Araujo AB, Durante R, Feldman HA, Goldstein I, McKinley JB. 1998. The relationship between depressive symptoms and male erectile dysfunction: cross-sectional results from the Massachusetts Male Aging Study. Psychosom Med 60: 458-465.
5. Armagan A, Kim NN, Goldstein I, Traish AM. 2006. Doseresponse relationship between testosterone add erectile function: evidence forthe existence ofa critical threshold. J Androl 27:517-526.
6. Baba K, Yajima M, Carrier S, Akkus E, Raman J, Nunes L, et al. 2000a. Effect of testosterone on the number of NADPH diaphorese-stained nerve fibers in the rat corpus covernosum and dorsal nerve. Urology 56:533-638.
7. Baba K, Yajima M, Carrier S, Morgan DM, Nunes L, Lue TF. et al. 2000b. Delayed testosterone replacement restores nitric oxide synthase-containing nerve fibres and the erectile response in rat penis. BJU Int 85:953-958.
8. Benet AE, Melman A. 1995. The epidemiology of erectile dysfunction. Urol Clin North Am 22:699-709.
9. Billups KL. 2005. Erectile dysfunction as an early sign of cardiovascular disease Int J Impot Res 17(suppl 1):S19-S24.
10. Burnett AL, Lowenstein CJ, Bradt DS, Chang TS, Snyder SH. 1992. Nitric oxide: a ohysiologic mediator of penile erection. Science 257:401-403.
11. Ch'i IC, Blackwell RQ. 1968. A controlled retrospective study of blackfoot disease, an endemic peripheral gangrene disease in Taiwan. Am J Epidemiol 88:7-24.
12. Chiou HY, Chiou ST, Hsu YH, Chou YL, Tseng CH, Wei ML. et al. 2001. Incidence of transitional cell carcinoma and arsenic in drinking water: a follow-up study of 8,102 residents in an arseniasis-endemic area in northeastern Taiwan. Am J Epidemiol 153:411-418.
13. Chiou HY, Huang WI, Su CL, Chang SF, Hsu YH, Chen CJ. 1997. Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. Stroke 28:1717-1723.
14. Feldman HA, Longcope C, Derby CA, Johannes CB, Araujo AB, Coviello AD, et al. 2002. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 87:589-598.
15. Hakim LS, Goldstein I. 1996. Diabetic sexual dysfunction. Endocrinial Metab Clin North Am 25:379-400.
16. Hwang TI, Lo HC, Tsai TF, Chiou HY. 2007. Association among hypogonadism, quality of life and erectile dysfunction in middle-aged and aged male in Taiwan. Int J Impot Res 19:69-75.
17. International Society for the Study of the Aging Male. 2007. Free & Bioavailable Testosterone Calculator. Available: http://www.issam.ch/ freetesto.htm [accessed 16 August 2007].
18. Jardin A, Wagner G, Khoury S, Giuliano I, Padma-Nathan H, Rosen R, eds. 2000, Erectile Dysfunction. 1st International Consultation on Erectile Dysfunction, 1-3 July 1999, Paris, France. London:Health Publications, Ltd.
19. Katusic ZS. 1996. Superoxide anion and endothelial regulation of arterial tone. Free Radic Biol Med 20:443-448.
20. Kim YC. 1999. Testosterone supplementation in the aging male. Int J Impot Res 11:343-352.
21. Liu SX, Athar M, Lippai I, Waldren C, Hei TK. 2001. Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity. Proc Natl Acad Sci USA 98:1643-1648.
22. Maiti S, Chatterjee AK. 2001. Effects on levels of glutathione and some related enzymes in tissues after an acute arsenic exposure in rats and their relationship to dietary protein deficiency. Arch Toxicol 75:531-537.
23. Marin R, Escrig A, Abrou P, Mas M. 1999. Androgen-dependent nitric oxide release in rat penis correlates with levels of constitutive nitric oxide synthase isoenzymes. Biol Reprod 61:1012-1016.
24. Martinez-Jabaloyas JM, Queipo-Zaragoza A, Pastor-Hernandez F, Gil-Salom M, Chuan-Nuez P. 2006. Testosterone levels in men with erectile dysfunction. BJU Int 97:1278-1283.
25. Morales A, Buvat J, Gooren LJ, Guay AT, Kaufman JM, Tan HM, et al. 2004. Endocrine aspects of sexual dysfunction in men. J Sex Med 1:69-81.
26. Moreland RB, Hsieh G, Nakane M, Brioni JD. 2001. The biochemical and neurologic basis for the treatment of male erectile dysfunction. J Pharmacol Exp Ther 296:225-234.
27. Park KH, Kim SW, Kim KD, Paick JS. 1999. Effects of androgens on the expression of nitric oxide synthase mRNAs in rat corpus cavernosum. BJU Int 83:327-333.
28. Ramanathan K, Batakumar BS, Panneerselvam C. 2002. Effects of ascorbic acid and alpha-tocopherol on arsenic-induced oxidative stress. Hum Exp Toxicol 21:675-680.
29. Ramanathan K, Shila S, Kumaran S, Panneerselvam C. 2003. Protective role of ascorbic acid and alpha-tocopherol on arsenic-induced microsomal dysfunctions. Hum Exp Toxicol 22:129-136.
30. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. 1997. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 49:822-830.
31. Salonia A, Briganti A, Deho F, Naspro R, Scapaticci E, Scattoni V, et al. 2003. Pathophysiology of erectile dysfunction. Int J. Androl 26:129-136.
32. Santra A, Maiti A, Chowdhury A, Mazumder DN. 2000. Oxidative stress in liver of mice exposed to arsenic-contaminated water. Indian J Gastroenterol 19:112-115.
33. Sarkar M, Chaudhuri GR, Chattopadhyay A, Biswas NM. 2003. Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats. Asian J Androl 5:27-31.
34. Shen Z, Chen Z, Lu Y, Chen F, Chen Z. 2000. Relationship between gene expression of nitric oxide synthase and androgens in rat corpus cavernosum. Chin Med J (Engl) 113:1092-1095.
35. Shiri R, Koskimaki J, Hakama M, Hakkinen J, Tammela TL, Huhtela H, et al, 2003. Prevalence and severity of erectile dysfunction in 50 to 75-year-old Finnish men. J Urol 170:2342-2344.
36. U.S. Environmental Protection Agency. 2007. Drinking Water Contaminants. Available: http://www.epa.gov/safewatdr/conteminants/index.html#primary/ [accessed 10 September 2007].
37. Vermeulen A. 1991. Androgens in the aging male. J Clin Endocrinol Metab 73:221-224.
38. Wang CH, Hsiao CK, Chen CL, Hsu LI. Chiou HY, Chen SY. et al. 2007. A review of the apidemiologic literature on the role of environmental arsenic exposure and cardiovascular diseases. Toxicol Appl Pharmacol 222:315-326.
39. Wang YH, Wu MM, Hong CT, Lien LM, Hsieh YG, Tseng HP, et al. 2007. Effects of arsenic exposure and genetic polymorphisms of p53, glutathione S-transferase M1, T1, and P1 on the risk of carotid atherosclerosis in Taiwan. Atherosclerosis 192:305-312.
40. Wein AJ, van Arsdalen KN. 1988. Drug-induced male sexual dysfunction. Urol Clin North Am 15:2341.
41. Wespes E, Amer E, Hatzichristou D, Montorsi F, Pryor J, Vardi Y. 2002. Guidelines on erectile dysfunction. Eur Urol 41:1-5.
42. WHO. 2006. Guidelines for Drinking-water Quality. 3rd ed. Geneva:World Health Organization.
43. Wu MM, Chiou HY, Hsueh YM, Hong CT, Su CL, Chang SF, et al. 2006. Effect of plasma homocysteine level and urinary monomethylarsonic acid on the risk of arsenic-associated carotid atherosclerosis. Toxicol Appl Pharmacol 216:168-175.
44. Zarazua S, Perez-Severiano F, Delgado JM, Martinez LM, Ortiz-Perez D, Jimenez-Capdeville ME. 2006. Decreased nitric oxide production in the rat brain after chronic arsenic exposure. Neurochem Res 31:1069-1077.