Extracts and constituents of Leontopodium alpinum enhance cholinergic transmission: Brain ACh increasing and memory improving properties

Biochemical Pharmacology

Volumn 76, Issue 2, 2008, Pages 236-248

  Hornick, Ariane ^a   Schwaiger, Stefan ^a   Rollinger, Judith M ^a   Vo, Nguyen Phung ^a   Prast, Helmut ^a   Stuppner, Hermann ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Acetylcholine release; Edelweiss; Isocomene; Object recognition; T maze

Indexed keywords

14 ACETOXYISOCOMENE; ACETYLCHOLINE; ACETYLCHOLINESTERASE; DICHLOROMETHANE; GALANTAMINE; ISOCOMENE; LEONTOPODIUM ALPINUM EXTRACT; SCOPOLAMINE; SESQUITERPENE DERIVATIVE; SILPHINENE; SILPHIPERFOLENE ACETATE;

ACETYLCHOLINE BRAIN LEVEL; ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLINERGIC TRANSMISSION; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ISOLATION; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; LEONTOPODIUM ALPINUM; LOCOMOTION; MAZE TEST; MEMORY; NEUROTRANSMISSION; NONHUMAN; NUCLEUS ACCUMBENS; OPEN FIELD BEHAVIOR; PLANT ROOT; PRIORITY JOURNAL; RAT; RECOGNITION; SYNAPSE; TASK PERFORMANCE;

ACETYLCHOLINESTERASE; ANIMALS; ASTERACEAE; BEHAVIOR, ANIMAL; BRAIN; CHOLINESTERASE INHIBITORS; FEMALE; GALANTAMINE; MEMORY; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES; TACRINE;

EID: 45649083646     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.04.015     Document Type: Article

References (42)

1. Stuppner H., Ellmerer E.P., Ongania K.H., and Dobner M. Bisabolane derivatives from Leontopodium alpinum. Helv Chim Acta 85 (2002) 2982-2989
2. Dobner M.J., Ellmerer E.P., Schwaiger S., Batsugkh O., Narantuya S., Stütz M., et al. New lignan, benzofuran, and sesquiterpene derivatives from the roots of Leontopodium alpinum and L. leontopodioides. Helv Chim Acta 86 (2003) 733-738
3. Dobner M.J., Schwaiger S., Jenewein I.H., and Stuppner H. Antibacterial activity of Leontopodium alpinum (Edelweiss). J Ethnopharm 89 (2003) 301-303
4. Schwaiger S., Adams M., Seger C., Ellmerer E.P., Bauer R., and Stuppner H. New constituents of Leontopodium alpinum and their in vitro leukotriene biosynthesis inhibitory activity. Planta Med 70 (2004) 978-985
5. Bartus R.T., Dean R.L., Beer B., and Lipps A.S. The cholinergic hypothesis of geriatric memory dysfunction: a critical review. Science 217 (1982) 408-417
6. Nizri E., Hamra-Amitay Y., Sicsic C., Lavon I., and Brenner T. Anti-inflammatory properties of cholinergic upregulation: a new role for acetylcholinesterase inhibitors. Neuropharmacology 50 (2006) 540-547
7. Grey A.I., Hook I.L., James P., and Sheridan H. Sesquiterpenes from Leontopodium alpinum. Phytochemistry 50 (1999) 1057-1060 [Corrigendum: Phytochemistry 2000; 54:551]
8. Bohlmann F., Le Van G., Pham T.V.C., Jacupovic J., Schuster A., Zabel V., et al. β-Isocomene, ein neues Sesquiterpen aus Berkheya-Arten. Phytochemistry 18 (1979) 1831-1834
9. Bohlmann F., and Jacupovic J. Neue Sesquiterpen-Kohlenwasserstoffe mit anomalen Kohlenstoffgerüst aus Silphium-arten. Phytochemistry 19 (1980) 259-265
10. Paxinos G., and Watson H. The rat brain in stereotaxic coordinates. 4th ed. (1998), Academic Press, Sidney
11. Kraus M.M., and Prast H. The nitric oxide system modulates in vivo release of acetylcholine in the nucleus accumbens induced by stimulation of the hippocampal fornix/fimbria projection. Eur J Neurosci 14 (2001) 1105-1112
12. Damsma G., Westerink B.H.C., de Boer P., de Vries J.B., and Horn A.S. Determination of basal acetylcholine release in freely moving rats by transstriatal dialysis coupled to on-line HPLC analysis: pharmacological aspects. Life Sci 43 (1988) 1161-1168
13. Prast H., Tran M.H., Fischer H., and Philippu A. Nitric oxide-induced release of acetylcholine in the nucleus accumbens: role of cyclic GMP, glutamate, and GABA. J Neurochem 71 (1998) 266-273
14. Ellman G.L., Courtney D., Andres V., and Featherstone R.M. A new and rapid calorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7 (1961) 88-95
15. Ingkaninan K., de Best C.M., van der Heijden R., Hofte A.J.P., Karabatak B., Irth H., et al. High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products. J Chromatogr A 872 (2000) 61-73
16. Rollinger J.M., Hornick A., Langer T., Stuppner H., and Prast H. Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products. J Med Chem 47 (2004) 6248-6254
17. Franklin K.B.J., and Paxinos G. The mouse brain in stereotaxic coordinates (1997), Academic Press, San Diego
18. Ennaceur A., and Delacour J. A new one-trial test for neurobiological studies of memory in rats. 1: behavioural data. Behav Brain Res 31 (1988) 47-59
19. Gerlai R. A new continuous alternation task in T-maze detects hippocampal dysfunction in mice. A strain comparison and lesion study. Behav Brain Res 95 (1998) 91-101
20. Prut L., and Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviours: a review. Eur J Pharmacol 463 (2003) 3-33
21. Kraus M.M., and Prast H. Involvement of nitric oxide, cyclic GMP and phosphodiesterase 5 in excitatory amino acid and GABA release in the nucleus accumbens evoked by activation of the hippocampal fimbria. Neuroscience 112 (2002) 331-343
22. Philippu A., Prast H., and Singewald N. Identification and dynamics of neuronal modulation and function in brain structures and nuclei by continuous determination of transmitter release rates using the push-pull superfusion technique: a compelling approach to in vivo brain research. Sci Pharm 64 (1996) 609-618
23. Zalkow L.H., Harris R.N., Van Derweer D., and Bertrand J.A. Isocomene: a novel sesquiterpene from Isocoma Wrightii. X-Ray crystal structure of the corresponding diol. J Chem Soc Chem Commun 13 (1977) 456-457
24. Bohlmann F., Le Van N., and Pickardt J. Natürlich vorkommende Terpen derivate. J Chem Ber 110 (1977) 3777-3781
25. Snape M.F., Misra A., Murray T.K., De Souza R.J., Williams J.L., Cross A.J., et al. A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donezepil and NXX-066. Neuropharmacology 38 (1999) 181-193
26. Flicker C., Ferris S.H., Crrok T., Bartus R.T., and Reisberg B. Cognitive function in normal aging and early dementia. In: Traber J., and Gispen W.H. (Eds). Senile dementia of the Alzheimer type (1985), Springer, Berlin, Heidelberg, New York 2-17
27. Lee A.C., Rahman S., Hodges J.R., Sahakian B.J., and Graham K.S. Associative and recognition memory for novel objects in dementia: implications for diagnosis. Eur J Neurosci 18 (2003) 1660-1670
28. Scali C., Giovannini M.G., Prosperi C., Bartolini L., and Pepeu G. Tacrine administration enhances extracellular acetylcholine in vivo and restores the cognitive impairment in aged rats. Pharmacol Res 36 (1997) 463-469
29. Prickaerts J., Sik A., van der Staay F.J., de Vente J., and Blokland A. Dissociable effects of acetylcholinesterase inhibitors and phosphodiesterase type 5 inhibitors on object recognition memory: acquisition versus consolidation. Psychopharmacology 177 (2005) 381-390
30. Sik A., Van Nieuwenhuyzen P., Prickaerts J., and Blokland A. Performance of different mouse strains in an object recognition task. Behav Brain Res 147 (2003) 49-54
31. Meyers B., and Domino E.F. The effect of cholinergic drugs on spontaneous alternation in rats. Arch Int Pharmacodyn 150 (1964) 3-4
32. Kokkinidis L., and Anisman H. Interaction between cholinergic and catecholaminergic agents in a spontaneous alternation task. Psychopharmacology 48 (1976) 261-270
33. Egger G.J., Livesey P.J., and Dawson R.G. Ontogenic aspects of central cholinergic involvement in spontaneous alternation behavior. Dev Psychobiol 6 (1973) 289-299
34. Delatour B., and Gisquet-Verrier P. Prelimbic cortex specific lesions disrupt delayed-variable response tasks in the rat. Behav Neurosci 110 (1996) 1282-1298
35. Ukai M., Shinkai N., and Kameyama T. Cholinergic receptor antagonists inhibit pirenzepine-induced dysfunction of spontaneous alternation performance in the mouse. Gen Pharmacol 26 (1995) 1529-1532
36. Spowart-Manning L., and van der Staay F.J. The T-maze continuous alternation task for assessing the effects of putative cognition enhancers in the mouse. Behav Brain Res 151 (2004) 37-46
37. Cummings J.L., and Kaufer D. Neuropsychiatric aspects of Alzheimer's disease: the cholinergic hypothesis revisited. Neurology 47 (1996) 876-883
38. Sinkiewicz-Jarosz H., Czlonkowska A., Siemiatkowski M., Maciejak P., Szyndler J., and Plaznik A. The effects of physostigmine and cholinergic receptor ligands on novelty-induced neophobia. J Neural Transm 107 (2000) 1403-1412
39. Carlsson M., and Carlsson A. Marked locomotor stimulation in monoamine-depleted mice following treatment with atropine in combination with clonidine. J Neural Transm 1 (1989) 317-322
40. Capone F., Oliverio A., Pomponi M., Marta M., Gatta F., and Pavone F. Effects of the novel acetylcholinesterase inhibitor N-octyl-1,2,3, 4-tetrahydro-9-aminoacridine on locomotor activity and avoidance learning in mice. Neurobiol Learn Mem 71 (1999) 301-307
41. Mach M., Grubbs R.D., Price W.A., Paton S.J., and Lucot J.B. Behavioral changes after acetylcholinesterase inhibition with physostigmine in mice. Pharmacol Biochem Behav 79 (2004) 533-540
42. Csernanski J.G., Martin M., Shah R., Bertchume A., Colvin J., and Dong H. Cholinesterase inhibitors ameliorate behavioural deficits induced by MK-801 in mice. Neuropsychopharmacology 30 (2005) 2135-2143