Association of the homeobox transcription factor gene ENGRAILED 2 with autistic disorder in Chinese children

Neuropsychobiology

Volumn 57, Issue 1-2, 2008, Pages 3-8

  Yang, Pinchen ^a,b   Lung, For Wey ^a,c,e,f   Jong, Yuh Jyh ^b   Hsieh, Hsin Yi ^a   Liang, Chung Ling ^d   Juo, Suh Hang Hank ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c KAOHSIUNG ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^d CHANG GUNG UNIVERSITY   (Taiwan)

^e NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^f Calo Psychiatric Center   (Taiwan)

Author keywords

Autism, children, China; ENGRAILED 2

Indexed keywords

TRANSCRIPTION FACTOR;

ADULT; ARTICLE; AUTISM; CHINESE; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ASIAN CONTINENTAL ANCESTRY GROUP; AUTISTIC DISORDER; CHILD; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DNA PRIMERS; FEMALE; GENE FREQUENCY; GENES, HOMEOBOX; GENOTYPE; HOMEODOMAIN PROTEINS; HUMANS; INTRONS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; TRANSCRIPTION, GENETIC;

EID: 45549104943     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000123115     Document Type: Article

References (20)

1. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders (DSM-TR), ed. 4, rev. Washington, American Psychiatric Association, 2000.
2. Fombonne E: The prevalence of autism. JAMA 2003;289:87-89.
3. Muhle R, Trentacoste SV, Rapin I: The genetics of autism. Pediatrics 2004;113:e472-e486.
4. Folstein SE, Rosen-Sheidley B: Genetics of autism: complex aetiology for a heterogeneous disorder. Nat Rev Genet 2001;2:943-955.
5. International Molecular Genetic Study of Autism Consortium (IMGSAC): Further characterization of the autism susceptibility locus auts1 on chromosome 7q. Hum Mol Genet 2001;10:973-982.
6. Badner JA, Gershon ES: Regional meta-analysis of published data supports linkage of autism with markers on chromosome 7. Mol Psychiatry 2002;7:56-66.
7. Schellenberg GD, Dawson G, Sung YJ, Estes A, Munson J, Rosenthal E, Rothstein J, Flodman P, Smith M, Coon H, Leong L, Yu CE, Stodgell C, Rodier PM, Spence MA, Minshew N, McMahon WM, Wijsman EM: Evidence for multiple loci from a genome scan of autism kindreds. Mol Psychiatry 2006;11:1049-1060, 979.
8. Gharani N, Benayed R, Mancuso V, Brzustowicz LM, Millonig JH: Association of the homeobox transcription factor, engrailed 2, 3, with autism spectrum disorder. Mol Psychiatry 2004;9:474-484.
9. Benayed R, Gharani N, Rossman I, Mancuso V, Lazar G, Kamdar S, Bruse SE, Tischfield S, Smith BJ, Zimmerman RA, Dicicco-Bloom E, Brzustowicz LM, Millonig JH: Support for the homeobox transcription factor gene engrailed 2 as an autism spectrum disorder susceptibility locus. Am J Hum Genet 2005;77:851-868.
10. Liu A, Joyner AL: En and gbx2 play essential roles downstream of fgf8 in patterning the mouse mid/hindbrain region. Development 2001;128:181-191.
11. Bauman ML, Kemper TL: Neuroanatomic observations of the brain in autism; in Bauman ML, Kemper TL (eds): The Neurobiology of Autism. Baltimore, John Hopkins University Press, 1986.
12. Courchesne E, Karns CM, Davis HR, Ziccardi R, Carper RA, Tigue ZD, Chisum HJ, Moses P, Pierce K, Lord C, Lincoln AJ, Pizzo S, Schreibman L, Haas RH, Akshoomoff NA, Courchesne RY: Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study. Neurology 2001;57:245-254.
13. Allen G, Courchesne E: Differential effects of developmental cerebellar abnormality on cognitive and motor functions in the cerebellum: an fMRI study of autism. Am J Psychiatry 2003;160:262-273.
14. Baader SL, Sanlioglu S, Berrebi AS, Parker-Thornburg J, Oberdick J: Ectopic overexpression of engrailed-2 in cerebellar Purkinje cells causes restricted cell loss and retarded external germinal layer development at lobule junctions. J Neurosci 1998;18:1763-1773.
15. Millen KJ, Wurst W, Herrup K, Joyner AL: Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse engrailed-2 mutants. Development 1994;120:695-706.
16. Kuemerle B, Zanjani H, Joyner A, Herrup K: Pattern deformities and cell loss in engrailed-2 mutant mice suggest two separate patterning events during cerebellar development. J Neurosci 1997;17:7881-7889.
17. Cheh MA, Millonig JH, Roselli LM, Ming X, Jacobsen E, Kamdar S, Wagner GC: En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder. Brain Res 2006;1116:166-176.
18. Ye S, Dhillon S, Ke X, Collins AR, Day IN: An efficient procedure for genotyping single nucleotide polymorphisms. Nucleic Acids Res 2001;29:E88.
19. Dudbridge F: Unphased User Guide. Technical Report 2006/5. Cambridge, MRC Biostatistics Unit, 2006.
20. Wang L, Jia M, Yue W, Tang F, Qu M, Ruan Y, Lu T, Zhang H, Yan H, Liu J, Guo Y, Zhang J, Yang X, Zhang D: Association of the ENGRAILED 2 (EN2) gene with autism in Chinese Han population. Am J Med Genet B Neuropsychiatr Genet 2007; [Epub ahead of print].