AH amyloidosis associated with an immunoglobulin heavy chain variable region (VH1) fragment: A case report

Amyloid

Volumn 15, Issue 2, 2008, Pages 125-128

  Miyazaki, Daigo ^a   Yazaki, Masahide ^a   Gono, Takahisa ^a   Kametani, Fuyuki ^b   Tsuchiya, Ayako ^a   Matsuda, Masayuki ^a   Takenaka, Yoshiaki ^c   Hoshii, Yoshinobu ^d   Ikeda, Shu Ichi ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c Takarazuka City Hospital   (Japan)

^d YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

AH amyloidosis; B cell lymphoproliferative disorder; Heavy chain variable region; VH1 subgroup

Indexed keywords

AMYLOID A PROTEIN; CYCLOSPORIN; DIPYRIDAMOLE; DIURETIC AGENT; IMMUNOGLOBULIN HEAVY CHAIN; PREDNISONE; AMYLOID;

AGED; AMYLOIDOSIS; ANAMNESIS; ARTICLE; CASE REPORT; CLINICAL FEATURE; DISEASE CLASSIFICATION; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOHISTOCHEMISTRY; KIDNEY BIOPSY; KIDNEY DISEASE; LABORATORY TEST; LYMPHOPROLIFERATIVE DISEASE; MALE; PRIORITY JOURNAL; AMINO ACID SEQUENCE; GENETICS; IMMUNOLOGY; INTESTINE MUCOSA; KIDNEY; METABOLISM; NEPHROTIC SYNDROME; PARAPROTEINEMIA; PATHOLOGY; REVIEW; STOMACH MUCOSA;

AGED; AMINO ACID SEQUENCE; AMYLOID; AMYLOIDOSIS; GASTRIC MUCOSA; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; INTESTINAL MUCOSA; KIDNEY; MALE; NEPHROTIC SYNDROME; PARAPROTEINEMIAS;

EID: 45549100417     PISSN: 13506129     EISSN: 17442818     Source Type: Journal    
DOI: 10.1080/13506120802006229     Document Type: Article

References (11)

1. Eulitz M, Weiss DT, Solomon A. Immunoglobulin heavychain associated amyloidosis. Proc Natl Acad Sci USA 1990;87:6542-6546.
2. Solomon A, Weiss DT, Murphy C. Primary amyloidosis associated with a novel heavy-chain fragment (AH amyloidosis). Am J Hematol 1994;45:171-176.
3. Tan SY, Murdoch IE, Sullivan TJ, Wright JE, Truong O, Hsuan JJ, Hawkins PN, Peppys MB. Primary localized orbital amyloidosis composed of the immunoglobulin gamma heavy chain CH3 domain. Clin Sci (Lond) 1994;87:487-491.
4. Mai HL, Sheikh-Hamad D, Herrera GA, Gu X, Truong LD. Immunoglobulin heavy chain can be amyloidogenic: morphologic characterization including immunoelectron microscopy. Am J Surg Pathol 2003;27:541-545.
5. Copeland JN, Kouides PA, Grieff M, Nadasdy T. Metachronous development of nonamyloidogenic lambda light chain deposition disease and IgG heavy chain amyloidosis in the same patient. Am J Surg Pathol 2003;27:1477-1482.
6. Yazaki M, Fushimi T, Tokuda T, Kametani F, Yamamoto K, Matsuda M, Shimojo H, Hoshii Y, Higuchi K, Ikeda S. A patient with severe renal amyloidosis associated with an immunoglobulin gamma-heavy chain fragment. Am J Kidney Dis 2004;43:e23-28.
7. Kaplan B, Martin BM, Boykov O, Gal R, Pras M, Shechtman I, Saute M, Kramer MR. Co-deposition of amyloidogenic immunoglobulin light and heavy chains in localized pulmonary amyloidosis. Virchows Arch 2005;447:756-761.
8. Gono T, Yazaki M, Fushimi T, Suzuki T, Uehara T, Sano K, Kametani F, Ito N, Matsushita M, Nakamura S, Hoshii Y, Matsuda M, Ikeda S. AH amyloidosis associated with lymphoplasmacytic lymphoma secreting a monoclonal γ heavy chain carrying an unusual truncated D segment. Am J Kidney Dis 2006;47:908-914.
9. Nasr SH, Colvin R, Markowitz GS. IgG1 λ light and heavy chain renal amyloidosis. Kidney Int 2006;70:7.
10. Hoshii Y, Setoguchi M, Iwata T, Ueda J, Cui D, Kawano H, Gondo T, Takahashi M, Ishihara T. Useful polyclonal antibodies against synthetic peptides corresponding to immunoglobulin light chain constant region for immunohistochemical detection of immunoglobulin light chain amyloidosis. Pathol Int 2001;51:264-270.
11. Johnson TA, Rassenti LZ, Kipps TJ. Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J Immunol 1997;158:235-246.