A Spontaneous Prothrombotic Disorder Resembling Heparin-induced Thrombocytopenia

American Journal of Medicine

Volumn 121, Issue 7, 2008, Pages 632-636

  Warkentin, Theodore E ^a,b   Makris, Michael ^c   Jay, Richard M ^d   Kelton, John G ^b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Heparin; Immunoglobulin G; Platelet; Prothrombotic; Thrombocytopenia

Indexed keywords

AMPICILLIN; ANCROD; DANAPAROID; ENOXAPARIN; HEPARIN; IMMUNOGLOBULIN G; LOW MOLECULAR WEIGHT HEPARIN; METHYLPREDNISOLONE; PHOSPHOLIPID ANTIBODY; SEROTONIN;

ADULT; AGED; ANAPHYLAXIS; ARTERY THROMBOSIS; ARTICLE; AUTOPSY; BRAIN EDEMA; BRAIN INFARCTION; CASE REPORT; CHILL; CLINICAL FEATURE; CONFIDENCE INTERVAL; CONTROLLED STUDY; CONVALESCENCE; CYANOSIS; DIAGNOSTIC PROCEDURE; DISEASE COURSE; DRUG WITHDRAWAL; ENZYME IMMUNOASSAY; FATALITY; FEMALE; FLUSHING; HEART ARREST; HEMIPARESIS; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; HYPOXEMIA; INFECTION; INFLAMMATION; LABORATORY TEST; LEG AMPUTATION; LEG ISCHEMIA; LUNG EMBOLISM; MALE; NECROSIS; NEUROSURGERY; PERIODONTITIS; PRIORITY JOURNAL; RECURRENT DISEASE; SEROLOGY; SIDE EFFECT; STROKE; TACHYCARDIA; THROMBECTOMY; THROMBOCYTE ACTIVATION; THROMBOCYTOPENIA; TREATMENT DURATION; TREATMENT OUTCOME;

ADULT; AGED; ANTIBODIES; FEMALE; HUMANS; IMMUNOASSAY; IMMUNOGLOBULIN G; MALE; PLATELET FACTOR 4; THROMBOCYTOPENIA; THROMBOSIS;

EID: 45549099235     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjmed.2008.03.012     Document Type: Article

References (13)

1. Warkentin T.E., and Kelton J.G. Delayed-onset heparin-induced thrombocytopenia and thrombosis. Ann Intern Med 135 (2001) 502-506
2. Rice L., Attisha W.K., Drexler A., and Francis J.L. Delayed-onset heparin-induced thrombocytopenia. Ann Intern Med 136 (2002) 210-215
3. Horsewood P., Warkentin T.E., Hayward C.P.M., and Kelton J.G. The epitope specificity of heparin-induced thrombocytopenia. Br J Haematol 95 (1996) 161-167
4. Kelton J.G., Sheridan D., Santos A., et al. Heparin-induced thrombocytopenia: laboratory studies. Blood 72 (1988) 925-930
5. Warkentin T.E., and Kelton J.G. Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med 344 (2001) 1286-1292
6. Warkentin T.E., Levine M.N., Hirsh J., et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 332 (1995) 1330-1335
7. Rauova L., Zhai L., Kowalska M.A., et al. Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. Blood 107 (2006) 2346-2353
8. Sheridan D., Carter C., and Kelton J.G. A diagnostic test for heparin-induced thrombocytopenia. Blood 67 (1986) 27-30
9. Visentin G.P., Moghaddam M., Beery S.E., et al. Heparin is not required for detection of antibodies associated with heparin-induced thrombocytopenia/thrombosis. J Lab Clin Med 138 (2001) 22-31
10. Mims M.P., Manian P., and Rice R. Acute cardiorespiratory collapse from heparin: a consequence of heparin-induced thrombocytopenia. Eur J Haematol 72 (2004) 366-369
11. Srinivasan A.F., Rice L., Bartholomew J.R., et al. Warfarin-induced skin necrosis and venous limb gangrene in the setting of heparin-induced thrombocytopenia. Arch Intern Med 164 (2004) 66-70
12. Warkentin T.E., Sheppard J.I., Sigouin C.S., et al. Gender imbalance and risk factor interactions in heparin-induced thrombocytopenia. Blood 108 (2006) 2937-2941
13. Martinuzzo M.E., Forastiero R.R., Adamczuk Y., et al. Antiplatelet factor 4-heparin antibodies in patients with antiphospholipid antibodies. Thromb Res 95 (1999) 271-279