Control of epithelial cell structure and developmental fate: Lessons from Helicobacter pylori

BioEssays

Volumn 30, Issue 6, 2008, Pages 515-520

  Mimuro, Hitomi ^a,b   Berg, Douglas E ^c,d   Sasakawa, Chihiro ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c WASHINGTON UNIVERSITY   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; CAGA PROTEIN; INTEGRIN; PHOSPHOTRANSFERASE; PROTEIN CAGL;

BACTERIAL INFECTION; BACTERIAL PHENOMENA AND FUNCTIONS; CELL FATE; CELL STRUCTURE; EPITHELIUM CELL; EUKARYOTE; HELICOBACTER PYLORI; HOST PATHOGEN INTERACTION; NONHUMAN; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; TYPE 4 SECRETION SYSTEM;

ADHESINS, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL ADHESION; BACTERIAL PROTEINS; CELL POLARITY; EPITHELIAL CELLS; GASTRIC MUCOSA; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HOST-PATHOGEN INTERACTIONS; HUMANS; INTEGRINS; MODELS, BIOLOGICAL; PHOSPHORYLATION; SIGNAL TRANSDUCTION; VIRULENCE;

BACTERIA (MICROORGANISMS); EUKARYOTA; HELICOBACTER PYLORI;

EID: 45549085270     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.20768     Document Type: Review

References (40)

1. Kwok T, Zabler D, Urman S, Rohde M, Hartig R, et al. 2007. Helicobacter exploits integrin for type IV secretion and kinase activation. Nature 449:862-866.
2. Amieva MR, El-Omar EM. 2008. Host-Bacterial Interactions in Helicobacter pylori Infection. Gastroenterology 134:306-323.
3. Sachs G, Weeks DL, Melchers K, Scott DR. 2003. The gastric biology of Helicobacter pylori. Annu Rev Physiol 65:349-369.
4. Croxen MA, Sisson G, Melano R, Hoffman PS. 2006. The Helicobacter pylori chemotaxis receptor TlpB (HP0103) is required for pH taxis and for colonization of the gastric mucosa. J Bacteriol 188:2656-2665.
5. Ilver D, Arnqvist A, Ogren J, Frick IM, Kersulyte D, et al. 1998. Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging. Science 279:373-377.
6. Mahdavi J, Sonden B, Hurtig M, Olfat FO, Forsberg L, et al. 2002. Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Science 297:573-578.
7. Aspholm M, Olfat FO, Norden J, Sonden B, Lundberg C, et al. 2006. SabA is the H. pylori hemagglutinin and is polymorphic in binding to sialylated glycans. PLoS Pathog 2:e110.
8. Viala J, Chaput C, Boneca IG, Cardona A, Girardin SE, et al. 2004. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol 5:1166-1174.
9. Brandt S, Kwok T, Hartig R, Konig W, Backert S. 2005. NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proc Natl Acad Sci USA 102:9300-9305.
10. Wilson KT, Crabtree JE. 2007. Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies. Gastroenterology 133:288-308.
11. Blaser MJ, Berg DE. 2001. Helicobacter pylori genetic diversity and risk of human disease. J Clin Invest 107:767-773.
12. Christie PJ, Vogel JP. 2000. Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells. Trends Microbiol 8:354-360.
13. Stein M, Bagnoli F, Halenbeck R, Rappuoli R, Fantl WJ, et al. 2002. c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol 43:971-980.
14. Poppe M, Feller SM, Romer G, Wessler S. 2007. Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility. Oncogene 26:3462-3472.
15. Geiger B, Bershadsky A, Pankov R, Yamada KM. 2001. Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk. Nat Rev Mol Cell Biol 2:793-805.
16. Xiong JP, Stehle T, Zhang R, Joachimiak A, Frech M, et al. 2002. Crystal structure of the extracellular segment of integrin (V(3 in complex with an Arg-Gly-Asp ligand. Science 296:151-155.
17. Nhieu GT, Enninga J, Sansonetti P, Grompone G. 2005. Tyrosine kinase signaling and type III effectors orchestrating Shigella invasion. Curr Opin Microbiol 8:16-20.
18. Mimuro H, Suzuki T, Tanaka J, Asahi M, Haas R, et al. 2002. Grb2 is a key mediator of Helicobacter pylori CagA protein activities. Mol Cell 10:745-755.
19. Amieva MR, Vogelmann R, Covacci A, Tompkins LS, Nelson WJ, et al. 2003. Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science 300:1430-1434.
20. Churin Y, Al-Ghoul L, Kepp O, Meyer TF, Birchmeier W, et al. 2003. Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response. J Cell Biol 161:249-255.
21. Murata-Kamiya N, Kurashima Y, Teishikata Y, Yamahashi Y, Saito Y, et al. 2007. Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene 26:4617-4626.
22. Saadat I, Higashi H, Obuse C, Umeda M, Murata-Kamiya N, et al. 2007. Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature 447:330-333.
23. Higashi H, Tsutsumi R, Muto S, Sugiyama T, Azuma T, et al. 2002. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295:683-686.
24. Tsutsumi R, Higashi H, Higuchi M, Okada M, Hatakeyama M. 2003. Attenuation of Helicobacter pylori CagA x SHP-2 signaling by interaction between CagA and C-terminal Src kinase. J Biol Chem 278:3664-3670.
25. Suzuki M, Mimuro H, Suzuki T, Park M, Yamamoto T, et al. 2005. Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion. J Exp Med 202:1235-1247.
26. Tsutsumi R, Takahashi A, Azuma T, Higashi H, Hatakeyama M. 2006. Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA. Mol Cell Biol 26:261-276.
27. Hatakeyama M. 2008. SagA of CagA in Helicobacter pylori pathogenesis. Curr Opin Microbiol.
28. Backert S, Moese S, Selbach M, Brinkmann V, Meyer TF. 2001. Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells. Mol Microbiol 42:631-644.
29. Brandt S, Shafikhani S, Balachandran P, Jin S, Hartig R, et al. 2007. Use of a novel coinfection system reveals a role for Rac1, H-Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytoskeletal rearrangements. FEMS Immunol Med Microbiol 50:190-205.
30. Bourzac KM, Botham CM, Guillemin K. 2007. Helicobacter pylori CagA induces AGS cell elongation through a cell retraction defect that is independent of Cdc42, Rac1, and Arp2/3. Infect Immun 75:1203-1213.
31. Hirata Y, Maeda S, Mitsuno Y, Tateishi K, Yanai A, et al. 2002. Helicobacter pylori CagA protein activates serum response element-driven transcription independently of tyrosine phosphorylation. Gastroenterology 123:1962-1971.
32. Yokoyama K, Higashi H, Ishikawa S, Fujii Y, Kondo S, et al. 2005. Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells. Proc Natl Acad Sc USA 102:9661-9666.
33. Mimuro H, Suzuki T, Nagai S, Rieder G, Suzuki M, et al. 2007. Helicobacter pylori dampens gut epithelial self-renewal by inhibiting apoptosis, a bacterial strategy to enhance colonization of the stomach. Cell Host Microbe 2:250-263.
34. Pillinger MH, Marjanovic N, Kim SY, Lee YC, Scher JU, et al. 2007. Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation. J Biol Chem 282:18722-18731.
35. Chang YJ, Wu MS, Lin JT, Pestell RG, Blaser MJ, et al. 2006. Mechanisms for Helicobacter pylori CagA-induced cyclin D1 expression that affect cell cycle. Cell Microbiol 8:1740-1752.
36. Gut A, Balda MS, Matter K. 1998. The cytoplasmic domains of a beta1 integrin mediate polarization in Madin-Darby canine kidney cells by selective basolateral stabilization. J Biol Chem 273:29381-29388.
37. Hynes RO. 2002. Integrins: bidirectional, allosteric signaling machines. Cell 110:673-687.
38. Lytton SD, Fischer W, Nagel W, Haas R, Beck FX. 2005. Production of ammonium by Helicobacter pylori mediates occludin processing and disruption of tight junctions in Caco-2 cells. Microbiology 151:3267-3276.
39. Pentecost M, Otto G, Theriot JA, Amieva MR. 2006. Listeria monocytogenes invades the epithelial junctions at sites of cell extrusion. PLoS Pathog 2:e3.
40. Tammer I, Brandt S, Hartig R, Konig W, Backert S. 2007. Activation of Abl by Helicobacter pylori: a novel kinase for CagA and crucial mediator of host cell scattering. Gastroenterology 132:1309-1319.