Antiretroviral therapy for HIV-1 infected adolescents in Uganda: Assessing the impact on growth and sexual maturation

Journal of Pediatric Infectious Diseases

Volumn 3, Issue 2, 2008, Pages 97-104

  Bakeera Kitaka, Sabrina ^a,f   McKellar, Mehri ^b   Snider, Cynthia ^b   Kekitiinwa, Adeodata ^a   Piloya, Theresa ^a   Musoke, Philippa ^a   Ronald, Allan ^c   Javanbakht, Marjan ^d   Colebunders, Robert ^c,e  

^a MAKERERE UNIVERSITY   (Uganda)

^b UNIVERSITY OF UTAH   (United States)

^c Academic Alliance for AIDS Care and Prevention in Africa   (Uganda)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF ANTWERP   (Belgium)

^f MAKERERE UNIVERSITY MEDICAL SCHOOL   (Uganda)

Author keywords

Adolescents; Africa; Antiretroviral therapy; HIV

Indexed keywords

ANTIRETROVIRUS AGENT; EFAVIRENZ; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; VIRUS RNA; ZIDOVUDINE;

ADOLESCENT; ADOLESCENT HEALTH; ADULT; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; BONE GROWTH; CD4 LYMPHOCYTE COUNT; CHILD GROWTH; DELAYED PUBERTY; DISEASE CLASSIFICATION; DRUG RESPONSE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MORTALITY; PATIENT COMPLIANCE; PERINATAL INFECTION; PRIORITY JOURNAL; REFERENCE VALUE; SCHOOL CHILD; SEXUAL MATURATION; UGANDA; VIRUS LOAD;

EID: 45449111387     PISSN: 13057707     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. G.D. Hussey, R.M. Reijnhart, A.M. Sebens, J. Burgess, S. Schaaf and S. Potgieter, Survival of children in Cape Town known to be vertically infected with HIV-1, S Afr Med J 88 (1998), 554-558.
2. R. Spira, P. Lepage, P. Msellati et al., Natural history of human immunodeficiency virus type 1 infection in children: A five-year prospective study in Rwanda. Mother-to-Child HIV-1 Transmission Study Group, Pediatrics 104 (1999), e56.
3. M. Marston, B. Zaba, J.A. Salomon, H. Brahmbhatt and D. Bagenda, Estimating the net effect of HIV on child mortality in African populations affected by generalized HIV epidemics, J Acquir Immune Defic Syndr 38 (2005), 219-227.
4. M.F. Schim van der Loeff, A. Hansmann, A.A. Awasana et al., Survival of HIV-1 and HIV-2 perinatally infected children in The Gambia, AIDS 17 (2003), 2389-2394.
5. K. Buchacz, A.D. Rogol, J.C. Lindsey et al., Delayed onset of pubertal development in children and adolescents with perinatally acquired HIV infection, J Acquir Immune Defic Syndr 33 (2003), 56-65.
6. J.M. Gertner, F.R. Kaufman, S.M. Donfield et al., Delayed somatic growth and pubertal development in human immunodeficiency virus-infected hemophiliac boys: Hemophilia Growth and Development Study, J Pediatr 124 (1994), 896-902.
7. E.M. Mahoney, S.M. Donfield, C. Howard, F. Kaufman and J.M. Gertner, HIV-associated immune dysfunction and delayed pubertal development in a cohort of young hemophiliacs. Hemophilia Growth and Development Study, J Acquir Immune Defic Syndr 21 (1999), 333-337.
8. M. de Martino, P.A. Tovo, L. Galli et al., Puberty in perinatal HIV-1 infection: A multicentre longitudinal study of 212 children, AIDS 15 (2001), 1527-1534.
9. M.W. Kline, S. Rugina, M. Ilie et al., Long-term follow-up of 414 HIV-infected Romanian children and adolescents receiving lopinavir/ ritonavir-containing highly active antiretroviral therapy, Pediatrics 119 (2007), 1116-1120.
10. E. George, F. Noël, G. Bois et al., Antiretroviral therapy for HIV-1-infected children in Haiti, J Infect Dis 195 (2007), 1411-1418.
11. B. Janssens, B. Raleigh, S. Soeung et al., Effectiveness of highly active antiretroviral therapy in HIV-positive children: Evaluation at 12 months in a routine program in Cambodia, Pediatrics 120 (2007), 1134-1140.
12. P. Fassinou, N. Elenga, F. Rouet et al., Highly active antiretroviral therapies among HIV-1-infected children in Abidjan, Côte d'Ivoire, AIDS 18 (2004), 1905-1913.
13. T. Puthanakit, A. Oberdorfer, N. Akarathum et al., Efficacy of highly active antiretroviral therapy in HIV-infected children participating in Thailand's National Access to Antiretroviral Program, Clin Infect Dis 41 (2005), 100-107.
14. UNAIDS Uganda, Country situation analysis: http://www.unaids.org/en/ Regions_Countries/Countries/Uganda.asp.
15. Ministry of Health (MoH) [Uganda] and ORC Macro. (2006). Uganda HIVAIDS Sero-behavioural Survey 2004-2005. Calverton, Maryland, USA: Ministry of Health and ORC Macro. http://www.aidsuganda.org/.
16. E. Borghi, M. de Onis, C. Garza et al., Construction of the World Health Organization child growth standards: Selection of methods for attained growth curves, Stat Med 25 (2006), 247-265.
17. M. de Onis, A.W. Onyango, E. Borghi, A. Siyam, C. Nishida and J. Siekmann, Development of a WHO growth reference for school-aged children and adolescents, Bull World Health Organ 85 (2007), 660-667.
18. World Health Organization. The WHO growth standards. http://www.who.int/ growthref/en/.
19. J.H. Oyugi, J. Byakika-Tusiime, F.D. Charlebois et al., Multiple validated measures of adherence indicate high levels of adherence to generic HIV antiretroviral therapy in a resource-limited setting, J Acquir Immune Defic Syndr 36 (2004), 1100-1102.
20. J. Robertson and N. Shilkofski, The Harriet Lane Handbook (17th ed). Philadelphia: Elsevier, 2005.
21. R.A. Ferrand, R. Luethy, F. Bwakura, H. Mujuru, R.F. Miller and E.L. Corbett, HIV infection presenting in older children and adolescents: A case series from Harare, Zimbabwe, Clin Infect Dis 44 (2007), 874-878.
22. C. Bolton-Moore, M. Mubiana-Mbewe, R.A. Cantrell et al., Clinical outcomes and CD4 cell response in children receiving antiretroviral therapy at primary health care facilities in Zambia, JAMA 298 (2007), 1888-1899.
23. S. Guillén, J.T. Ramos, R. Resino, J.M. Bellón and M.A. Muñoz, Impact on weight and height with the use of HAART in HIV-infected children, Pediatr Infect Dis J 26 (2007), 334-338.
24. K. Buchacz, A.D. Rogol, J.C. Lindsey et al., Delayed onset of pubertal development in children and adolescents with perinatally acquired HIV infection, J Acquir Immune Defic Syndr 33 (2003), 56-65.
25. N. Nabukeera-Barungi, I. Kalyesubula, A. Kekitiinwa, J. Byakika-Tusiime and P. Musoke, Adherence to antiretroviral therapy in children attending Mulago Hospital, Kampala, Ann Trop Paediatr 27 (2007), 123-131.
26. P.M. Flynn, B.J. Rudy, J.C. Lindsey et al., Long-term observation of adolescents initiating HAART therapy: Three-year follow-up, AIDS Res Hum Retroviruses 23 (2007), 1208-1214.