Highly efficient method for the synthesis of carboxamides from carboxylic acids and amines using pyridine-3-sulfonyl chloride (3-PSC)

Chemistry Letters

Volumn 37, Issue 5, 2008, Pages 506-507

  Funasaka, Setsuo ^a   Kato, Koji ^a   Mukaiyama, Teruaki ^a,b  

^a KITASATO INSTITUTE   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 45449111029     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2008.506     Document Type: Article

References (30)

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29. 1HNMR. It indicates that by-products, such as pyridine-3-sulfonic acid and pyridine-3-sulfoxamide, are transferred to the aqueous layer by aqueous workup.
30. 3 hydrochloric acid (3 times), brine, dried over anhydrous sodium sulfate, and evaporated. The crude product was purified by preparative TLC to afford the corresponding carboxamide.