Divide and conquer: how asymmetric division shapes cell fate in the hematopoietic system

Current Opinion in Immunology

Volumn 20, Issue 3, 2008, Pages 302-307

  Congdon, Kendra L ^a   Reya, Tannishtha ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR;

CELL DIFFERENTIATION; CELL DIVISION; CELL FATE; CELL RENEWAL; DAUGHTER CELL; DROSOPHILA; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; HUMAN; IMMUNE SYSTEM; LEUKEMOGENESIS; LYMPHOCYTE ACTIVATION; NONHUMAN; REVIEW; STEM CELL; T LYMPHOCYTE;

ANIMALS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; HEMATOPOIETIC STEM CELLS; INVERTEBRATES; LYMPHOCYTE ACTIVATION;

EID: 45449096835     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2008.05.003     Document Type: Review

References (29)

1. Betschinger J., and Knoblich J.A. Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates. Curr Biol 14 (2004) R674-685
2. Morrison S.J., and Kimble J. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 441 (2006) 1068-1074
3. Yu F., Kuo C.T., and Jan Y.N. Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology. Neuron 51 (2006) 13-20
4. Chia W., Somers W.G., and Wang H. Drosophila neuroblast asymmetric divisions: cell cycle regulators, asymmetric protein localization, and tumorigenesis. J Cell Biol 180 (2008) 267-272
5. Gonzalez C. Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells. Nat Rev Genet 8 (2007) 462-472
6. Spangrude G.J., Heimfeld S., and Weissman I.L. Purification and characterization of mouse hematopoietic stem cells. Science 241 (1988) 58-62
7. Uchida N., and Weissman I.L. Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin-Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow. J Exp Med 175 (1992) 175-184
8. Ho A.D. Kinetics and symmetry of divisions of hematopoietic stem cells. Exp Hematol 33 (2005) 1-8
9. Takano H., Ema H., Sudo K., and Nakauchi H. Asymmetric division and lineage commitment at the level of hematopoietic stem cells: inference from differentiation in daughter cell and granddaughter cell pairs. J Exp Med 199 (2004) 295-302
10. Punzel M., Zhang T., Liu D., Eckstein V., and Ho A.D. Functional analysis of initial cell divisions defines the subsequent fate of individual human CD34(+)CD38(-) cells. Exp Hematol 30 (2002) 464-472
11. Giebel B., Zhang T., Beckmann J., Spanholtz J., Wernet P., Ho A.D., and Punzel M. Primitive human hematopoietic cells give rise to differentially specified daughter cells upon their initial cell division. Blood 107 (2006) 2146-2152
12. Punzel M., Liu D., Zhang T., Eckstein V., Miesala K., and Ho A.D. The symmetry of initial divisions of human hematopoietic progenitors is altered only by the cellular microenvironment. Exp Hematol 31 (2003) 339-347
13. Ema H., Takano H., Sudo K., and Nakauchi H. In vitro self-renewal division of hematopoietic stem cells. J Exp Med 192 (2000) 1281-1288
14. Schroeder T. Asymmetric cell division in normal and malignant hematopoietic precursor cells. Cell Stem Cell 1 (2007) 479-481
15. Duncan A.W., Rattis F.M., DiMascio L.N., Congdon K.L., Pazianos G., Zhao C., Yoon K., Cook J.M., Willert K., Gaiano N., et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol 6 (2005) 314-322
16. Wu M., Kwon H., Rattis F., Blum J.M., Zhao C., Ashkenazi R., Jackson T.L., Gaiano N., Oliver T., and Reya T. Imaging hematopoietic precursor division in real time. Cell Stem Cell 1 (2007) 541-554. Utilizing Notch signaling as a sensor for HSC identity, real-time imaging of hematopoietic precursors demonstrates that they undergo both symmetric and asymmetric divisions and that divisional symmetry is responsive to both extrinsic cues and intrinsic subversion through the expression of oncogenes.
17. Beckmann J., Scheitza S., Wernet P., Fischer J.C., and Giebel B. Asymmetric cell division within the human hematopoietic stem and progenitor cell compartment: identification of asymmetrically segregating proteins. Blood 109 (2007) 5494-5501. This work identifies four proteins asymmetrically localized in a percentage of mitotic human hematopoietic progenitors, demonstrating that hematopoietic cells may possess the ability to polarize and divide asymmetrically.
18. Kai T., and Spradling A. Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries. Nature 428 (2004) 564-569
19. Brawley C., and Matunis E. Regeneration of male germline stem cells by spermatogonial dedifferentiation in vivo. Science 304 (2004) 1331-1334
20. Amarante-Mendes G.P., McGahon A.J., Nishioka W.K., Afar D.E., Witte O.N., and Green D.R. Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL. Oncogene 16 (1998) 1383-1390
21. Daley G.Q., Van Etten R.A., and Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science 247 (1990) 824-830
22. Regala R.P., Weems C., Jamieson L., Khoor A., Edell E.S., Lohse C.M., and Fields A.P. Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer. Cancer Res 65 (2005) 8905-8911
23. Grifoni D., Garoia F., Bellosta P., Parisi F., De Biase D., Collina G., Strand D., Cavicchi S., and Pession A. aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia. Oncogene 26 (2007) 5960-5965
24. Gardiol D., Zacchi A., Petrera F., Stanta G., and Banks L. Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression. Int J Cancer 119 (2006) 1285-1290
25. Saito T., and Yokosuka T. Immunological synapse and microclusters: the site for recognition and activation of T cells. Curr Opin Immunol 18 (2006) 305-313
26. Chang J.T., Palanivel V.R., Kinjyo I., Schambach F., Intlekofer A.M., Banerjee A., Longworth S.A., Vinup K.E., Mrass P., Oliaro J., et al. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 315 (2007) 1687-1691. This work demonstrates that formation of the immunological synapse during T cell activation establishes a retained polarization resulting in the differential segregation of cell fate determinants and the asymmetric division of activated T cells, producing individual daughter cells of both the memory and effector lineages.
27. Siegrist S.E., and Doe C.Q. Extrinsic cues orient the cell division axis in Drosophila embryonic neuroblasts. Development 133 (2006) 529-536
28. Ludford-Menting M.J., Oliaro J., Sacirbegovic F., Cheah E.T., Pedersen N., Thomas S.J., Pasam A., Iazzolino R., Dow L.E., Waterhouse N.J., et al. A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. Immunity 22 (2005) 737-748
29. Klein U., and Dalla-Favera R. Germinal centres: role in B-cell physiology and malignancy. Nat Rev Immunol 8 (2008) 22-33