Piperidine-containing β-arylpropionic acids as potent antagonists of αvβ3/αvβ5 integrins

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 20, 2004, Pages 5227-5232

  De Corte, Bart L ^a   Kinney, William A ^a   Liu, Li ^a   Ghosh, Shyamali ^a   Brunner, Livia ^a   Hoekstra, William J ^a   Santulli, Rosemary J ^a   Tuman, Robert W ^a   Baker, Judith ^a   Burns, Candace ^a   Proost, Jef C ^b   Tounge, Brett A ^a   Damiano, Bruce P ^a   Maryanoff, Bruce E ^a   Johnson, Dana L ^a   Galemmo Jr , Robert A ^a  

^a Welsh McKean Roads Spring Hse P ^*  (United States)

^b Johnson Johnson Pharmaceutical R D   (United States)

Author keywords

Aryl propionic acids; Integrin; Vitronectin

Indexed keywords

ARYLPROPIONIC ACID DERIVATIVE; CARBON; CARBOXYLIC ACID; CD51 ANTIGEN; PIPERIDINE; VITRONECTIN RECEPTOR;

ARTICLE; CHEMICAL BOND; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; HUMANS; INTEGRIN ALPHAVBETA3; INTEGRINS; PIPERIDINES; PROPIONIC ACIDS; PROTEIN BINDING; RATS; RECEPTORS, VITRONECTIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4544378784     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.06.061     Document Type: Article

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