Investigation on liquid chromatographic separation of basic compounds using silica column with aqueous/organic mobile phase containing triethylamine and acetic acid

Biomedical Chromatography

Volumn 18, Issue 7, 2004, Pages 443-449

  Wu, An Bang ^a   Huang, Ming Chun ^a,b   Ho, Hsiu O ^a   Yeh, Geng Cheng ^a   Sheu, Ming Thau ^a,c  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b DEPARTMENT OF HEALTH   (Taiwan)

^c NONE   (Taiwan)

Author keywords

Acetic acid; Aqueous eluents; Basic compounds; Silica column; TH, tetrahydrozoline HC1; Triethylamine

Indexed keywords

COLUMN CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE; IONIZATION OF LIQUIDS; ORGANIC SOLVENTS; PH; SILICA;

AQUEOUS ELUENT; AQUEOUS SOLVENTS; BASIC COMPOUNDS; ELUENTS; MOBILE PHASIS; RETENTION TIME; SILANOL GROUPS; SILICA COLUMN; TH, TETRAHYDROZOLINE HC1; TRIETHYLAMINES;

ACETIC ACID;

ACETIC ACID; ACETONITRILE; METHANOL; ORGANIC COMPOUND; ORGANIC SOLVENT; SILICON DIOXIDE; TRIETHYLAMINE;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL INTERACTION; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE; IONIZATION; PHASE SEPARATION; PROTON TRANSPORT; SYSTEM ANALYSIS;

EID: 4544370139     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.334     Document Type: Article

References (25)

1. Atwood JG, Schmidt GJ and Slavin W. Improvements in liquid chromatography column life and method flexibility by saturating the mobile phase with silica. Journal of Chromatography 1979; 171: 109.
2. Bidlingmeyer BA, Del Rios JK and Korpi J. Separation of organic amine compounds on silica gel with reversed-phase eluents. Analytical Chemistry 1982; 54: 442.
3. Brons C and Olieman C. Study of the high-performance liquid chromatographic separation of reducing sugars applied to be determination of lactose in milk. Journal of Chromatography 1983; 259: 79.
4. Butterfield AG, Cooper JK and Midha KK. Simultaneous determination of procainamide and N-acetylprocainamide in plasma by high-performance liquid chromatography. Journal of Pharmaceutical Sciences 1978; 67: 839.
5. Cox GB and Stout RW. Study of the retention mechanisms for basic compounds on silica under 'pseudo-reversed-phase conditions'. Journal of Chromatography 1987: 384: 315.
6. Cox GB, Loscombe CR and Sugden K. Some applications of bonded-phase high-performance liquid chromatography to the analysis of pharmaceutical formulations. Analytica Chimica Acta 1977: 92: 345.
7. Dutcher JS and Strong JM. Determination of plasma procainamide and N-acetylprocainamide concentration by high-pressure liquid chromatography. Clinical Chemistry 1977; 23: 1318.
8. Huang MC, Ho HO, Yeh GC, Ke WT, Lin LC, Hsu T-M. Bruce, Kao CC and Sheu MT. Development of high-performance liquid chromatographic method for bioanalytical application with sulpiride. Journal of Chromatography B 2001; 763: 157.
9. Huang MC, Ho HO, Wen KC and Sheu MT. Application of HPLC method using normal phase column in a comparative pharmacokinetic study of two sulpiride tablet formulations. Journal of Food and Drug Analysis 2002; 10: 88.
10. Jane J. The separation of a wide range of drugs of abuse by high-pressure liquid chromatography. Journal of Chromatography 1975; 111: 227.
11. Kraak JC. Techniques in Liquid Chromatography. Simpson CF (ed.). Wiley: New York, 1982; 304.
12. Law B. Use of silica with reverse-phase type eluents for the analysis of basic drugs and metabolites. Trends in Analytical Chemistry 1990; 9: 31.
13. Lingeman H, Underberg WJM. Non-modified stationary phase for the analysis of basic compounds. Trends in Analytical Chemistry 1988; 7: 346-351.
14. McKeown AP, Euerby MR, Lomax H, Johnson CM, Ritchie HJ and Woodruff M. The use of silica for liquid chromatographic/mass spectrometric analysis of basic analytes. Journal of Separation Sciences 2001; 24: 835.
15. Naidong W, Shou W, Chen YL and Jiang X. Novel liquid chromatographic-tandem mass spectrometric methods using silica columns and aqueous-organic mobile phases for quantitative analysis of polar ionic analytes in biological fluids. Journal of Chromatography B 2001; 754: 387.
16. Peat MA and Jennison TA. High-performance liquid chromatography of quinidine in plasma, with use of a microparticulate silica column. Clinical Chemistry 1978; 24: 2166.
17. Pershing LK, Peat MA and Finkle BS. An HPLC method for the quantitation of quinidine and its metabolites in plasma: an application to a quinidine-phenytoin drug interaction study. Journal of Analytical Toxicology 1982; 6: 153.
18. Richardson H and Bidlingmeyer BA. Bare silica as a reverse-phase stationary phase: liquid chromatographic separation of antihistamines with buffered aqueous organic mobile phases. Journal of Pharmaceutical Sciences 1984; 73: 1480.
19. Scott RPW. The silica gel surface and its interaction with solvent and solute in chromatography. Journal of Chromatographic Sciences 1980; 18: 297.
20. Shi RJY, Bent LZ and Lin ET. High-performance liquid chromatographic assay of basic amine drugs in plasma and urine using a silica gel column and an aqueous mobile phase, I. Amiloride. Journal of Chromatography 1986: 377: 399.
21. Shi RJY, Gee WL, Williams RL and Lin ET. High performance liquid chromatographic assay for basic amine drugs in plasma and urine using a silica gel column and an aqueous mobile phase, II. Chlorpheniramine. Journal of Liquid Chromatography 1987; 10: 3101.
22. Shi RJY, Schaeck JJ, Gee WL, Williams RL and Lin ET. High performance liquid chromatographic assay for meptazinol and metabolite in plasma and urine using a silica gel column and an aqueous mobile phase. Journal of Liquid Chromatography 1991; 14: 765.
23. Smith RM and Rabuor JO. Separation of basic drugs by high-performance liquid chromatography on a silica column using a methanol-ethylenediamine buffer. Journal of Chromatography 1989; 464: 117-123.
24. Wheals BB. Isocratic multi-column high-performance liquid chromatography as a technique for qualitative analysis and its application to the characterisation of basic drugs using an aqueous methanol solvent. Journal of Chromatography 1980; 187: 65.
25. Yoshida T and Okada T. Peptide separation in normal-phase liquid chromatography: study of selectivity and mobile phase effects on various columns. Journal of Chromatography A 1999: 840: 1.