Differentiation of the electrophysiological effects on the atrial myocardium between the pure Na channel blocker, pilsicainide, and flecainide

Cardiovascular Drugs and Therapy

Volumn 18, Issue 4, 2004, Pages 295-303

  Kanemoto, Masashi ^a   Shimizu, Akihiko ^a   Yamagata, Toshihiko ^a   Esato, Masahiro ^a   Ueyama, Takeshi ^a   Yoshiga, Yasuhiro ^a   Kakugawa, Hiroyuki ^a   Kametani, Ryousuke ^a   Inoue, Noriko ^a   Sawa, Akira ^a   Matsuzaki, Masunori ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

antiarrhythmic drug; atrial vulnerability; flecainide; pilsicainide; sodium channel blocker

Indexed keywords

ANTIARRHYTHMIC AGENT; FLECAINIDE; PILSICAINIDE; SODIUM CHANNEL BLOCKING AGENT;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; FEMALE; HEART ATRIOVENTRICULAR NODE; HEART ATRIUM CONDUCTION; HEART ATRIUM CONTRACTION; HEART ATRIUM FIBRILLATION; HEART ATRIUM FLUTTER; HEART ATRIUM MUSCLE; HEART ELECTROPHYSIOLOGY; HEART MUSCLE REFRACTORY PERIOD; HEART VENTRICLE TACHYCARDIA; HUMAN; MALE; PRIORITY JOURNAL; REENTRY TACHYCARDIA; WOLFF PARKINSON WHITE SYNDROME;

ADULT; ANTI-ARRHYTHMIA AGENTS; ATRIAL FLUTTER; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; FEMALE; FLECAINIDE; HEART ATRIA; HEART CONDUCTION SYSTEM; HEART VENTRICLES; HUMANS; LIDOCAINE; MALE; MIDDLE AGED; MYOCARDIUM; PROSPECTIVE STUDIES; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL; RESEARCH DESIGN; SODIUM CHANNEL BLOCKERS; TACHYCARDIA, ATRIOVENTRICULAR NODAL REENTRY; TACHYCARDIA, VENTRICULAR; TREATMENT OUTCOME; WOLFF-PARKINSON-WHITE SYNDROME;

EID: 4544365230     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:CARD.0000041249.35724.da     Document Type: Article

References (32)

1. Hattori Y, Hidaka T, Aisaka K, Satoh F, Ishihara T. Effect of SUN 1165, a new potent antiarrhythmic agent, on the kinetics of rate-dependent block of Na channels and ventricular conduction of extrasystoles. J Cardiovasc Pharmacol 1988;11:407-412.
2. Atarashi H, Inoue H, Hiejima K, et al. for the PSTAFT Investigations: Conversion of recent-onset atrial fibrillation by a single oral dose of pilsicainide (Pilsicainide Suppression Trial on Atrial Fibrillation). Am J Cardiol 1996;78:694-697.
3. The Sicillian Gambit. A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. Task force of the working group on arrhythmias of the Europian Society of Cardiology. Circulation 1991;68:1729-1741.
4. Wyndham C, Amat-y-Leon F, Wu D, et al. Effects of cycle length on atrial vulnerability. Circulation 1977;55:260-267.
5. Shimizu A, Centurion OA. Electrophysiological properties of human atrium in atrial fibrillation. Cardiovasc Res 2002;54:302-314.
6. Esato M, Shimizu A, Chun Y-H, Tatsuno H, Yamagata T, Matsuzaki M. Electrophysiologic effects of a class I antiarrhythmic agent, cibenzoline, on the refractoriness and conduction of the human atrium in vivo. J Cardiovasc Pharmacol 1996;28:321-327.
7. Shimizu A, Fukatani M, Konoe A, Isomoto S, Centurion OA, Yano K. Electrophysiological effects of a new class III antiarrhythmic agent (E-4031) on the conduction and refractoriness of the in vivo human atrium. Cardiac Res 1993;27:1333-1338.
8. Kumagai K, Akimitsu S, Kawahira K, et al. Electrophysiological properties in chronic lone atrial fibrillation. Circulation 1991;84:1662-1668.
9. Cosio FG, Palacios J, Vidal JM, Cocina EG, Gomez-Sanchez MA, Tamargo L. Electrophysiologic studies in atrial fibrillation: Slow conduction of premature impulses: A possible manifestation of the background for reentry. Am J Cardiol 1983;51:122-130.
10. Cosio FG, Llovet A, Vidal JM. Mechanism and clinical significance of atrial repetitive response in man. Pacing Clin Electrophysiol 1983;6:53-59.
11. Ohe T, Matsuhisa M, Kamakura S, Yamada J, Sato I, Nakajima K. Relation between the widening of the fragmented atrial activity zone and atrial fibrillation. Am J Cardiol 1983;53:1219-1222.
12. Shimizu A, Fukatani M, Tanigawa M, Mori M, Hashiba K. Intra-atrial conduction delay and fragmented atrial activity in patients with paroxysmal atrial fibrillation. Jpn Circ J 1989;53:1023-1030.
13. Morita H, Kusano-Fukushima K, Nagase S, et al. Atrial fibrillation and atrial vulnerability in patients with Brugada syndrome. J Am Coll Cardiol 2002;40:1437-1444.
14. Shimizu A, Yoshiga Y, Ymagata T, et al. New method of determining the atrial fibrillation cycle length during human atrial fibrillation. J Cardiovasc Electrophysiol 2003;14:965-970.
15. Hattori Y, Inomata N, Aisaka K, Ishihara T. Electrophysiologic actions of N-(2,6-dimethylphenyl)-8-pyrrolizidine-acetamide hydrochloride hemihydrate (SUN1165), a new antiarrhythmic agent. J Cardiovascular Pharmacology 1986;8:998-1002.
16. Conard GJ, Ober RE. Metabolism of flecainide. Am J Cardiol 1984;53:41B-51B.
17. Kodama I, Ogawa S, Inoue H, et al. Profile of aprindine, pilsicainide and Pirmenol in the Framework of the Sicilian Gambit. Jpn Circ J 1999;63:1-12.
18. Pires LA, Huang SK, Wagshal AB, Kulkarni RS. Electrophysiological effect of propofol on the normal cardiac conduction system. Cardiology 1996;87:319-324.
19. Sharpe MD, Dobkowski WB, Murkin JM, Klein G, Yee R. Propofol has no direct effect on sinoatrial node function or on normal atrioventricular and accessory pathway conduction in Wolff-Parkinson-White syndrome during alfentanil/midazolam anesthesia. Anethsesiology 1995;82:888-895.
20. Iino I, Atarashi H, Saito H, et al. The influence of single dose of SUN1165 on electrophysiologic and homodynamic parameters - The evaluation of patients with paroxysmal atrial tachycardia-. Clinical Pharmacology 1989;20:677-685. (in Japanease)
21. Yoshiga Y, Shimizu A, Yamagata T, et al. Effects of flecainide on the electrophysiological properties of atrial vulnerability in humans. Circulation J 2003;67:437-442.
22. Kanki H, Mitamura H, Takatsuki S, et al. Postrepolarization refractoriness as a potential anti-atrial fibrillation mechanism of pilsicainide, a pure sodium channel blocker with slow recovery kinetics. Cardiovascular Drugs and Therapy 1998;12:475-482.
23. Shinagawa K, Mitanura H, Takeshita A, et al. Determination of refractory periods and conduction velocity during atrial fibrillation using atrial capture in dogs: direct assessment of the wavelength and its modulation by a sodium channel blocker, pilsicainide. J Am Coll Cardiol 2000;35:246-253.
24. Terazawa T, Suzuki M, Goto T, et al. Suppressive effect of SUN1165 on supraventricular tachycardia. Am Heart J 1991;121:1437-1444.
25. Shoda M, Ohnishi T, Umeda J, Kasanuki H, Hosoda S. The effect of SUN1165 on electrophysiologic action, induction of tachycardia, hemodynamic action in supraventricular tachycardia and ventricular tachycardia. Rhinshoiyaku 1998;14:75-88. (in Japanease).
26. Roden DM. Treatment of cardiovascular disorders: Arrhythmias. In: Melmon KL, Morrelli HF, Hoffman BB, Nierenberg DW, eds. Clinical Parmacology: Basic Principles in Therapeutics. New York: McGraw-Hill, 1992:151-185.
27. Campbell TJ. Kinetics of onset of rate dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea pig ventricle, and provide a theoretical basis for their subclassification. Cardiovasc Res 1983;17:344-352.
28. Inoue M, Inoue D, Ishibashi K, et al. Effect of pilsicanide on the atrial fibrillation threshold in guineas pig atria. A comparative study with disopyramide, lidocaine and flecainide. Jpn Heart J 1993;34:301-312.
29. Shimizu A, Fukatani M, Tanigawa M, et al. Mechanism of the suppression of repetitive atrial firing by isoproterenol: Comparison with disopyramide. Int J Cardiol 1994;43:175-183.
30. Boineau J, Schenessler R, Mooney C, et al. Natural and evoked atrial flutter due to circus movement in dogs: Role of abnormal atrial pathways, slow conduction, non-uniform refractory period distribution and premature beats. Am J Cardiol 1980;45:1167-1181.
31. Johnson NJ, Wit AL, Danilo P, Rosen MR. Characteristics of initiation and termination of catecholamine-induced triggered activity in atrial fibers of the coronary sinus. Circulation 1986;74:1168-1179.
32. Saksena S, Prakash A, Krol RB, et al. Regional endocardial mapping of spontaneous and induced atrial fibrillation in patients with heart disease and refractory atrial fibrillation. Am J Cardiol 1999;84:840-889.