Inoculation of Lactobacillus expressing hCGβ in the vagina induces an anti-hCGβ antibody response in murine vaginal mucosa

Journal of Reproductive Immunology

Volumn 63, Issue 2, 2004, Pages 111-122

  Yao, Xiao Ying ^a   Wang, Hong Mei ^a   Li, Da Jin ^a   Yuan, Min Min ^a   Wang, Xiu Li ^a   Yu, Min ^a   Wang, Ming Yan ^a   Zhu, Ying ^a   Meng, Yi ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

hCG ; Immunocontraception; Mucosal immunization; Recombinant lactobacillus; Reproductive tract

Indexed keywords

CHORIONIC GONADOTROPIN ANTIBODY; CHORIONIC GONADOTROPIN BETA SUBUNIT; GAMMA INTERFERON; INTERLEUKIN 4;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CELL PROLIFERATION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; IMMUNOCONTRACEPTION; INOCULATION; LACTOBACILLUS; LACTOBACILLUS CASEI; LAVAGE; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; SPLEEN LYMPHOCYTE; VAGINA MUCOSA; WESTERN BLOTTING;

ANIMALS; ANTIBODIES; CELL PROLIFERATION; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; CONTRACEPTION, IMMUNOLOGIC; CYTOKINES; ELECTROPORATION; FEMALE; GENE EXPRESSION; GENETIC VECTORS; HUMANS; LACTOBACILLUS; LYMPHOCYTES; MICE; MICE, INBRED BALB C; MUCOUS MEMBRANE; SPLEEN; VAGINA;

EID: 4544336997     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2004.06.002     Document Type: Article

References (19)

1. H. Angelakopoilos, and L.H. Elizabeth Pilot study of phoP-/phoQ-deleted Salmonella enterica Serovar Typhimurium expressing Helicobacter pylori urease in adult volunteers Infect. Immun. 68 2000 2135 2141
2. M.A.D. Antonio, S.E. Hawes, and S.L.B. Hillier The identification of vaginal Lactobacillus species and the demographic and microbiologic characteristics of women colonized by these species J. Infect. Dis. 180 1999 1950 1956
3. C. Barbes, and S. Boris Potential role of lactobacilli as prophylactic agents against genital pathogens AIDS Patient Care STDS 13 1999 747 751
4. E.R. Boskey, K.M. Telsch, K.J. Whaley, T.R. Moench, and R.A. Cone Acid production by vaginal flora in vitro is consistent with the rate and extent of vaginal acidification Infect. Immunol. 67 1999 5170 5175
5. L.B. Corbeil, and R.H. BonDurant Immunity to bovine reproductive infections Vet. Clin. North. Am. Food Anim. Pract. 17 2001 567 583
6. M.J. Gosalges, V. Monedero, and G.P. Martinez Elements involved in catabolite repression and substrate induction of the lactose operon in Lactobacillus casei J. Bacteriol. 181 1999 3928 3934
7. C. Grangette, H. Muller-Alouf, D. Goudercourt, M.C. Geoffroy, M. Turneer, and A. Mercenier Mucosal immune responses and protection against tetanus toxin after intranasal immunization with recombinant Lactobacillus plantarum Infect. Immun. 69 2001 1547 1553
8. P.A. Kozlowski, S. Cu-Uvin, M.R. Neutra, and T.P. Flanigan Comparison of the oral, rectal and vaginal immunization routes for induction of antibodies in rectal and genital tract secretions of women Infect. Immun. 65 1997 1387 1394
9. C.B.M. Maassen, J.D. Laman, M.J. Heijine den Bak-Glashouwer, F.J. Teilen, J.C.P.A. van Holten-Neelen, L. Hoogterjling, C. Antonissen, R.J. Leer, P.H. Pouwels, W.J.A. Boersma, and D.M. Shaw Instruments for oral disease-intervention strategies: recombinant Lactobacillus casei expressing tetanus toxin fragment C for vaccination or myelin proteins for oral tolerance induction in multiple sclerosis Vaccine 1999 2117 2128
10. R. Meima, B.J. Haijema, H. Dijkastra, G.J. Hann, G. Venema, and S. Bron Role of enzymes of homologous recombination in illegitimate plasmid recombination in Bacillus subtilis J. Bacteriol. 179 1997 1219 1229
11. R.K. Naz Vaccine for contraception targeting sperm Immun. Rev. 171 1999 193 202
12. R. Pal, O. Singh, L.V. Rao, and G.P. Talwar Bioneutralization capacity of the antibodies generated in woman by the beta subunit of human chorionic gonadotrophin (βhCG) and βhCG associated with alpha subunit of ovine luteinizing hormone linked to carriers Am. J. Reprod. Immunol. 22 1990 124 126
13. G. Reid Probiotic agents to protect the urogenital tract against infection Am. J. Clin. Nutr. 73 Suppl 2 2001 437S 443S
14. M.W. Russell Immunization for protection of the reproductive tract: a review Am. J. Reprod. Immunol. 47 2002 265 268
15. L. Scheppler, M. Vogel, A.W. Zuercher, M. Zuercher, J.E. Germond, S.M. Miescher, and B.M. Stadler Recombinant Lactobacillus johnsonii as a mucosal vaccine delivery vehicle Vaccine 26 2002 2913 2920
16. D.M. Shaw, B. Gaerthe, R.J. Leer, J.G. Van Der Stap, C. Smittenaar, M. Heijne Den Bak-Glashouwer, J.E. Thole, F.J. Tielen, P.H. Pouwels, and C.E. Havenith Engineering the microflora to vaccinate the mucosa: serum immunoglobulin G responses and activated draining cervical lymph nodes following mucosal application of tetanus toxin fragment C-expressing lactobacilli Immunology 100 2000 510 518
17. M. Singh, S.K. Das, S. Suri, L. Singh, and G.P. Talwar Regain of fertility and normality of progeny born during below protective threshold antibody titers in women immunized with the HSD-hCG vaccine Am. J. Reprod. Immunol. 39 1998 395 398
18. G.P. Talwar, O. Singh, R. Pal, N. Chatterjee, P. Sahai, K. Dhall, J. Kaur, S.K. Das, S. Suri, K. Buckshee, L. Saraya, and B.N. Saxena A vaccine that prevents pregnancy in women Proc. Natl. Acad. Sci. U.S.A. 91 1994 8532 8536
19. C.R. Wira, R.M. Rossoll, and C. Kaushic Antigen-presenting cells in the female reproductive tract: influence of estradiol on antigen presentation by vaginal cells Endocrinology 141 2000 2877 2885