CD4+ T cells in the pathogenesis of murine ocular toxoplasmosis

Infection and Immunity

Volumn 72, Issue 9, 2004, Pages 4966-4972

  Lu, Fangli ^a,b   Huang, Shiguang ^a,c   Kasper, Lloyd H ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; EYE INFECTION; HISTOPATHOLOGY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOPATHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTOZOAL INFECTION; T LYMPHOCYTE; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, CD4; ANTIGENS, CD8; CD4-POSITIVE T-LYMPHOCYTES; EYE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL; TOXOPLASMOSIS, OCULAR;

EID: 4544328679     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.9.4966-4972.2004     Document Type: Article

References (40)

1. Abu el-Asrar, A. M., K. Geboes, K. F. Tabbara, S. A. al-Kharashi, L. Missotten, and V. Desmet. 1998. Immunopathogenesis of conjunctival scarring in trachoma. Eye 12:453-460.
2. Anderson, S. E., S. C. Bautista, and J. S. Remington. 1976. Specific antibody-dependent killing of Toxoplasma gondii by normal macrophages. Clin. Exp. Immunol. 26:375-380.
3. + T cells determine cyst number in Toxoplasma gondii infection. J. Immunol. 145: 3438-3441.
4. + T cells. Infect. Immun. 70:434-443.
5. Dannemann, B. R., V. A. Morris, F. G. Araujo, and J. S. Remington. 1989. Assessment of human natural killer and lymphokine-activated killer cell cytotoxicity against Toxoplasma gondii trophozoites and brain cysts. J. Immunol. 143:2684-2691.
6. Feron, E. J., V. N. Klaren, E. A. Wierenga, G. M. Verjans, and A. Kijlstra. 2001. Characterization of Toxoplasma gondii-specific T cells recovered from vitreous fluid of patients with OT. Investig. Ophthalmol. Vis. Sci. 42:3228-3232.
7. Gazzinelli, R. T., A. Brezin, Q. Li, R. B. Nussenblatt, and C. C. Chan. 1994. Toxoplasma gondii: acquired OT in the murine model, protective role of TNF-α and IFN-γ. Exp. Parasitol. 78:217-229.
8. + T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J. Immunol. 146:286-292.
9. Gilbert, R. E., D. T. Dunn, S. Lightman, P. I. Murray, C. E. Pavesio, P. D. Gormley, J. Masters, S. P. Parjer, and M. R. Stanford. 1999. Incidence of symptomatic toxoplasma eye disease: etiology and public health implications. Epidemiol. Infect. 123:283-289.
10. + T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells. J. Immunol. 147:2310-2316.
11. Haque, S., I. Khan, A. Haque, and L. Kasper. 1994. Impairment of the cellular immune response in acute murine toxoplasmosis: regulation of interleukin 2 production and macrophage-mediated inhibitory effects. Infect. Immun. 62:2908-2916.
12. Hu, M. S., J. D. Schwartzman, A. C. Lepage, I. A. Khan, and H. L. Kasper. 1999. Experimental OT induced in naive and preinfected mice by intracameral inoculation. Ocul. Immunol. Inflamm. 7:17-26.
13. Johnson, L. L., and P. C. Sayles. 2002. Deficient humoral responses underlie susceptibility to Toxoplasma gondii in CD4-deficient mice. Infect. Immun. 70:185-191.
14. Kang, H., J. S. Remington, and Y. Suzuki. 2000. Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-γ, TNF-α, and inducible nitric oxide synthase. J. Immunol. 164:2629-2634.
15. Kasper, L. H., T. Matsuura, S. Fonseka, J. Arruda, J. Y. Channon, and I. A. Khan. 1996. Induction of gamma-delta T cells during acute murine infection with Toxoplasma gondii. J. Immunol. 157:5521-5527.
16. Kernacki, K. A., R. P. Barrett, J. A. Hobden, and L. D. Hazlett. 2000. Macrophage inflammatory protein-2 is a mediator of polymorphonuclear neutrophil influx in ocular bacterial infection. J. Immunol. 164:1037-1045.
17. Khan, I. A., K. A. Smith, and L. H. Kasper. 1988. Induction of antigen-specific parasiticidal cytotoxic T-cell splenocytes by a major membrane protein (P30) of Toxoplasma gondii. J. Immunol. 141:3600-3605.
18. + T-cell clone protects against acute Toxoplasma gondii infection in mice. J. Immunol. 152:1856-1860.
19. Khan, I. A., M. E. Eckel, E. R. Pfefferkorn, and L. H. Kasper. 1988. Production of gamma interferon by cultured human lymphocytes stimulated with a purified membrane protein (P30) from Toxoplasma gondii. J. Infect. Dis. 157:979-984.
20. Liesenfeld, O., H. Kang, D. Park, T. A. Nguyen, C. V. Parkhe, H. Watanabe, T. Abo, A. Sher, J. S. Remington, and Y. Suzuki. 1999. TNF-alpha, nitric oxide and IFN-gamma are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii. Parasite Immunol. 21:365-376.
21. + T-cell dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii. J. Exp. Med. 184:597-607.
22. Lu, F., S. Huang, and L. H. Kasper. 2003. Interleukin-10 and pathogenesis of murine OT. Infect. Immun. 71:7159-7163.
23. Mineo, J. R., and L. H. Kasper. 1994. Attachment of Toxoplasma gondii to host cells involves major surface protein, SAG-1 (P30). Exp. Parasitol. 79: 11-20.
24. Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145-173.
25. Norose, K., H. S. Mun, F. Aosai, M. Chen, L. X. Piao, M. Kobayashi, Y. Iwakura, and A. Yano. 2003. IFN-gamma-regulated Toxoplasma gondii distribution and load in the murine eye. Investig. Ophthalmol. Vis. Sci. 44:4375-4381.
26. Pearlman, E., J. H. Lass, D. S. Bardenstein, M. Kopf, F. E., Jr. Hazlett, E. Diaconu, and J. W. Kazura. 1995. Interleukin 4 and T helper type 2 cells are required for development of experimental onchocercal keratitis (river blindness). J. Exp. Med. 182:931-940.
27. Roberts, F., and R. McLeod. 1999. Pathogenesis of toxoplasmic retinochoroiditis. Parasitol. Today 15:51-57.
28. Rodgers, C. A., and J. R. Harris. 1996. Ocular toxoplasmosis in HIV infection. Int. J. STD AIDS 7:307-309.
29. Ronday, M. J. H., J. V. Ongkosuwito, A. Rothova, and A. Kijlstra. 1999. Intraocular anti-Toxoplasma gondii IgA antibody production in patients with OT. Am. J. Ophthalmol. 127:294-300.
30. Sasaki, M. G., J. Arana, and A. G. Leite. 2000. Ocular involvement in systemic toxoplasmosis: a case report. Braz. J. Infect. Dis. 4:301-306.
31. Sayles, P. C., G. W. Gibson, and L. L. Johnson. 2000. B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii. Infect. Immun. 68:1026-1033.
32. Schreiber, R. D., and H. A. Feldman. 1980. Identification of the activator system for antibody to Toxoplasma as the classical complement pathway. J. Infect. Dis. 141:366-369.
33. + T cells to control acute Toxoplasma gondii infection. Infect. Immun. 71:309-316.
34. + cytotoxic T lymphocytes lyse Toxoplasma gondii-infected cells. J. Immunol. 147:3955-3959.
35. Suzuki, Y. 2002. Host resistance in the brain against Toxoplasma gondii. J. Infect. Dis. 185:S58-S65.
36. Suzuki, Y., A. Sher, G. Yap, D. Park, L. E. Neyer, O. Liesenfeld, M. Fort, H. Kang, and E. Gufwoli. 2000. IL-10 is required for prevention of necrosis in the small intestine and mortality in both genetically resistant BALB/c and susceptible C57BL/6 mice following peroral infection with Toxoplasma gondii. J. Immunol. 164:5375-5382.
37. + T cells in mice. J. Immunol. 140:3943-3946.
38. Thomas, J., and B. T. Rouse. 1997. Immunopathogenesis of herpetic ocular disease. Immunol. Res. 16:375-386.
39. Turunen, H. J., P. O. Leinikki, and K. M. Saari. 1983. Demonstration of intraocular synthesis of immunoglobulin G Toxoplasma antibodies for specific diagnosis of toxoplasmic chorioretinitis by enzyme immunoassay. J. Clin. Microbiol. 17:988-992.
40. + cytotoxic cells. J. Parasitol. 75:411-416.