The GABAB agonist baclofen blocks the expression of sensitisation to the locomotor stimulant effect of amphetamine

Behavioural Pharmacology

Volumn 15, Issue 5-6, 2004, Pages 397-401

  Bartoletti, M ^a   Gubellini, C ^a   Ricci, F ^a   Gaiardi, M ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Baclofen; D amphetamine; GABAB receptor; Locomotor activity; Sensitisation

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; AMPHETAMINE; BACLOFEN; PSYCHOSTIMULANT AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; CENTRAL STIMULANT AGENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; CONTROLLED STUDY; DRUG DEPENDENCE; DRUG EFFECT; HYPERACTIVITY; LOCOMOTION; MALE; NONHUMAN; RAT; SENSITIZATION; ADDICTION; ANIMAL; MOTOR ACTIVITY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

AMPHETAMINE; ANIMALS; BACLOFEN; CENTRAL NERVOUS SYSTEM STIMULANTS; GABA AGONISTS; MALE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE-RELATED DISORDERS;

EID: 4544327588     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-200409000-00014     Document Type: Article

References (28)

1. B receptor in gamma-vinyl-GABA's inhibition of cocaine-induced increases in nucleus accumbens dopamine. Synapse 31:151-153.
2. Box GEP, Cox DR (1964). Analysis of transformations. J R Statist Soc Series B 26:211-252.
3. Brebner K, Childress AR, Roberts DC (2002). A potential role for GABA (B) agonists in the treatment of psychostimulant addiction. Alcohol Alcohol 37:478-484.
4. Brebner K, Phelan R, Roberts DC (2000). Intra-VTA baclofen attenuates cocaine self-administration on a progressive ratio schedule of reinforcement. Pharmacol Biochem Behav 66:857-862.
5. A receptors within the ventral tegmental area. Neurochem Res 17:101-106.
6. De Vries TJ, Schoffelmeer ANM, Binnekade R, Mulder AH, Vanderschuren LJMJ (1998). Drug-induced reinstatement of heroin-and cocaine-seeking behaviour following long-term extinction is associated with expression of behavioural sensitization. Eur J Neurosci 10:3565-3571.
7. Eckermann K, Beasley A, Yang P, Gaytan O, Swann A, Dafny N (2001). Methylphenidate sensitization is modulated by valproate. Life Sci 69:47-57.
8. Enrico P, Bouma M, DeVries JB, Westerink BHC (1998). The role of afferents to the ventral tegmental area in the handling stress-induced increase in the release of dopamine in the medial prefrontal cortex: a dual probe microdialysis study in the rat brain. Brain Res 779:205-213.
9. Fadda P, Scherma M, Fresu A, Collu M, Fratta W (2003). Baclofen antagonizes nicotine-, cocaine- and morphine-induced dopamine release in the nucleus accumbens of rat. Synapse 50:1-5.
10. Hotsenpiller G, Wolf ME (2003). Baclofen attenuates conditioned locomotion to cues associated with cocaine administration and stabilizes extracellular glutamate levels in rat nucleus accumbens. Neuroscience 118:123-134.
11. Kalivas PW, Duffy P, Eberhardt H (1990). Modulation of A10 dopamine neurons by γ-aminobutyric acid agonists. J Pharmacol Exp Ther 253:858-866.
12. Karler R, Bedingfield JB, Thai DK, Calder LD (1997). The role of the frontal cortex in the mouse in behavioral sensitization to amphetamine. Brain Res 757:228-235.
13. Klitenick MA, DeWitte P, Kalivas PW (1992). Regulation of somatodendritic dopamine release in the rat ventral tegmental area by opioids and GABA: an in vivo microdialysis study. J Neurosci 12: 2623-2632.
14. Ohmori IK, Abekawa T, Koyama T (1997). Clonazepam prevents the development of sensitization to methamphetamine. Pharmacol Biochem Behav 58:875-879.
15. Ohmori IK, Abekawa T, Koyama T (2000). The role of benzodiazepine receptors in the acquisition and expression of behavioral sensitization to methamphetamine. Pharmacol Biochem Behav 65:705-710.
16. Pierce RC, Kalivas PW (1997). A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Res 25:192-216.
17. Robinson TE, Becker JB, Presty SK (1982). Long-term facilitation of amphetamine-induced rotational behavior and striatal dopamine release produced by single exposure to amphetamine: sex differences. Brain Res 16:231-241.
18. Robinson TE, Berridge KC (1993). The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Rev 18:247-291.
19. B agonist baclofen modifies cocaine self-administration in rats. Behav Pharmacol 9:195-206.
20. Steketee JD, Kalivas PW (1991). Sensitization to psychostimulants and stress after injection of pertussis toxin into the A10 dopamine region. J Pharmacol Exp Ther 259:916-924.
21. Steward J, Badiani A (1993). Tolerance and sensitization to the behavioral effects of drugs. Behav Pharmacol 4:289-312.
22. Vanderschuren LJ, Schmidt ED, De Vries TJ, Van Moorsel C, Tilders FJ, Schofflmeer AN (1999). A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine and neurochemical sensitisation in rats. J Neurosci 19:9579-9686.
23. Vanderschuren LJMJ, Kalivas PW (2000). Alteration in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Psychopharmacology (Berl) 151:99-120.
24. Westerink BHC, Enrico P, Feimann J, DeVries JB (1998). The pharmacology of mesocortical dopamine neurons: a dual probe microdialysis study in the ventral tegmental area and prefrontal cortex. J Pharmacol Exp Ther 285:143-154.
25. Westerink BHC, Kwint HG, DeVries JB (1997). Eating induced dopamine release from mesolimbic neurons is mediated by NMDA receptors in the ventral tegmental area: a dual probe microdialysis study. J Neurochem 69:662-668.
26. Wolf ME (1998). The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants. Prog Neurobiol 54:679-720.
27. Woo SH, Kim HS, Yun JS, Lee MK, Oh KW, Seong YH, et al. (2001). Inhibition of baclofen on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity. Pharmacol Res 43:335-340.
28. Yang P, Beasley A, Swann A, Dafny N (2000). Valproate modulates the expression of methylphenidate (Ritalin) sensitization. Brain Res 874:216-220.