Study of a chaotic mixing system for DNA chip hybridization chambers

Physics of Fluids

Volumn 16, Issue 9, 2004, Pages

  Raynal, Florence ^a   Plaza, Frédéric ^a   Beuf, Aurélien ^a,b   Carrière, Philippe ^a   Souteyrand, Eliane ^c   Martin, Jean René ^a   Cloarec, Jean Pierre ^a   Cabrera, Michel ^a  

^a ECOLE CENTRALE DE LYON   (France)

^b UNIVERSITÉ DE LYON   (France)

^c Rosatech   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; DISPERSIONS; DNA; FLOW OF FLUIDS; OPTIMIZATION; SAMPLING;

DNA CHIP HYBRIDIZATION; MICROMIXING SYSTEMS; TIME-PERIODIC FLOW;

MACHINABILITY;

DNA; FLOW MODELING; FLUID FLOW; MIXING;

EID: 4544283937     PISSN: 10706631     EISSN: None     Source Type: Journal    
DOI: 10.1063/1.1775807     Document Type: Article

References (15)

1. Supplement issue of Nat. Genet. 32(1), 1-60 (2002).
2. H. Aref, "Stirring by chaotic advection," J. Fluid Mech. 143, 1 (1984).
3. S. Wiggins, Global Bifurcations and Chaos (Springer-Verlag, New York, 1988).
4. J. M. Ottino, The Kinematics of Mixing: Stretching, Chaos and Transport (Cambridge University Press, New York, 1989).
5. S. W. Jones and H. Aref, "Chaotic advection in pulsed source-sink systems," Phys. Fluids 31, 469 (1988).
6. V. Rom-Kedar, A. Leonard, and S. Wiggins, "An analytical study of the transport, mixing and chaos in an unsteady vortical flow," J. Fluid Mech. 214, 347 (1990).
7. K. Bajer and H. K. Moffatt, "On a class of steady Stokes flows with chaotic streamlines," J. Fluid Mech. 212, 337 (1990).
8. V. Toussaint, Ph. Carrière, and F. Raynal, "A numerical Eulerian approach to mixing by chaotic advection," Phys. Fluids 7, 2587 (1995).
9. V. Toussaint, Ph. Carrière, J. Scott, and J. N. Gence, "Spectral decay of a passive scalar in chaotic mixing," Phys. Fluids 12, 2834 (2000).
10. M. K. McQuain, K. Seale, J. Peek, T. S. Fisher, S. Levy, M. A. Stremler, and F. Haselton, "Chaotic mixer improves microarray hybridization," Anal. Biochem. 325, 215 (2004).
11. A. D. Stroock, S. K. W. Dertinger, A. Adjari, I. Mezic, H. A. Stone, and G. M. Whitesides, "Chaotic mixer for microchannels," Science 295, 647 (2002).
12. Y. K. Lee, J. Deval, R Tabeling, and C. M. Ho, "Chaotic mixing in electrokinetically and pressure driven micro flows," in Proceedings of the l4th IEEE Workshop on Micro Electro Mechanical Systems (IEEE, New York, 2001), p. 483-486.
13. V. Girault and P. A. Raviart, Finite Element Methods for Navier-Stokes Equations (Springer-Verlag, New York, 1986).
14. J. P. Eckmann and D. Ruelle, "Ergodic theory of chaos," Rev. Mod. Phys. 57, 617 (1985).
15. Ph. Carrière, F. Raynal, and F. Plaza, "Etude par simulation numérique du mélange par advection chaotique dans une chambre d'hybridation," Technical report, LMFA, Ecole Centrale de Lyon, March 2003.