Anti-metastatic effect of capecitabine on human colon cancer xenografts in nude mouse rectum

International Journal of Cancer

Volumn 112, Issue 1, 2004, Pages 135-142

  Ninomiya, Itasu ^a   Terada, Itsuro ^a   Yoshizumi, Tetsuya ^a   Takino, Takahisa ^a   Nagai, Noboru ^a   Morita, Akihiko ^a   Fushida, Sachio ^a   Nishimura, Genichi ^a   Fujimura, Takashi ^a   Ohta, Tetsuo ^a   Miwa, Koichi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Capecitabine; Lung metastasis; Lymph node metastasis; Rectal xenograft model; Thymidine phosphorylase

Indexed keywords

CAPECITABINE; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; THYMIDINE PHOSPHORYLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER MODEL; CANCER PATIENT; CANCER PREVENTION; CANCER SURVIVAL; COLON CARCINOMA; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVATION; GASTROINTESTINAL CARCINOMA; GENE AMPLIFICATION; HUMAN; HUMAN CELL; LUNG METASTASIS; LYMPH NODE METASTASIS; MALE; MEDICAL ASSESSMENT; METASTASIS INHIBITION; MOUSE; NONHUMAN; NUDE MOUSE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; XENOGRAFT;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; COLONIC NEOPLASMS; DEOXYCYTIDINE; GASTROINTESTINAL NEOPLASMS; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; RECTAL NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; THYMIDINE PHOSPHORYLASE; TRANSPLANTATION, HETEROLOGOUS;

EID: 4544279531     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20360     Document Type: Article

References (27)

1. Miwa M, Ura M, Nishida M, Sawada N, Ishikawa T, Mori K, Shimma N, Umeda I, Ishitsuka H. Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. Eur J Cancer 1998;34:1274-81.
2. Ishitsuka H, Miwa M, Ishikawa T, Ura M, Sawada N, Nishida M, Fukase Y, Yamamoto T, Mori K, Arasaki M, Umeda I, Shimma N. Capecitabine: an orally available fluoropyrimidine with tumor selectivectivity. Proc Am Assoc Cancer Res 1995;36:407.
3. Ishitsuka H. Capecitabine: preclinical pharmacology studies. Invest New Drugs 2000;18:343-54.
4. Hoff PM, Ansari R, Batist G, Cox J, Kocha W, Kuperminc M, Maroun J, Walde D, Weaver C, Harrison E, Burger HU, Osterwalder B, et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study. J Clin Oncol 2001;19:2282-92.
5. Van Cutsem E, Twelves C, Cassidy J, Allman D, Bajetta E, Boyer M, Bugat R, Findlay M, Frings S, Jahn M, McKendrick J, Osterwalder B, et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III study. J Clin Oncol 2001;19:4097-106.
6. Cartwright TH, Cohn A, Varkey JA, Chen YM, Szatrowski TP, Cox JV, Schulz JJ. Phase II study of oral capecitabine in patients with advanced or metastatic pancreatic cancer. J Clin Oncol 2002;20:160-4.
7. Twelves C, Boyer M, Findlay M, Cassidy J, Weitzel C, Barker C, Osterwalder B, Jamieson C, Hieke K. Capecitabine (Xeloda™) improves medical resource use compared with 5-fluorouracil plus leucovorin in a phase III trial conducted in patients with advanced colorectal carcinoma. Eur J Cancer 2001;37:597-604.
8. Chishima T, Miyagi Y, Wang X, Yamaoka H, Shimada H, Moossa AR, Hoffman RM. Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression. Cancer Res 1997;57:2042-7.
9. Blin N, Stafford DW. A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res 1976;3:2303-8.
10. Wang X, Fu X, Brown PD, Crimmin MJ, Hoffman RM. Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res 1994;54:4726-8.
11. Kashtan H, Rabau M, Mullen JB, Wong AH, Roder JC, Shpitz B, Stern HS, Gallinger S. Intra-rectal injection of tumour cells: a novel animal model of rectal cancer. Surg Oncol 1992;1:251-6.
12. Yang M, Baranov E, Jiang P, Sun FX, Li XM, Li L, Hasegawa S, Bouvet M. Al-Tuwaijri M, Chishima T, Shimada H, Moossa AR, et al. Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases. Proc Natl Acad Sci U S A 2000;97:1206-11.
13. Endo Y, Sasaki T, Harada F, Noguchi M. Specific detection of metastasized human tumor cells in embryonic chicks by the polymerase chain reaction. Jpn J Cancer Res 1990;81:723-6.
14. 4-pentyloxycarbonyl- 5′-deoxy-5-fluorocytidine (capecitabine). Biol Pharm Bull 1998;21:713-7.
15. Ishikawa T, Ura M, Yamamoto T, Tanaka Y, Ishitsuka H. Selective inhibition of spontaneous pulmonary metastasis of Lewis lung carcinoma by 5′-deoxy-5-fluorouridine. Int J Cancer 1995;61:516-21.
16. Kondo H, Hara Y, Sugata S, Karube Y, Matsushima Y, Ishitsuka H. Activation of 5′-deoxy-5-fluorouridine by thymidine phosphorylase in human tumors. Chem Pharm Bull (Tokyo) 1983;31:175-78.
17. Ishikawa T, Sekiguchi F, Fukase Y, Sawada N, Ishitsuka H. Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts. Cancer Res 1998;58:685-90.
18. Okada Y, Tsuchiya H, Shimizu H, Tomita K, Nakanishi I, Sato H, Seiki M, Yamashita K, Hayakawa T. Induction and stimulation of 92-kDa gelatinase/type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α. Biochem Biophys Res Commun 1990;171:610-7.
19. Siegal GP, Thorgeirsson UP, Russo RG, Wallace DM, Liotta LA, Berger SL. Interferon enhancement of the invasive capacity of Ewing sarcoma cells in vitro. Proc Natl Acad Sci U S A 1982;79:4064-8.
20. Hujanen ES, Turpeenniemi-Hujanen T. Recombinant interferon alpha and gamma modulate the invasive potential of human melanoma in vitro. Int J Cancer 1991;47:576-81.
21. Naylor MS, Stamp GW, Balkwill FR. Investigation of cytokine gene expression inhuman colorectal cancer. Cancer Res 1990;50:4436-40.
22. Naylor MS, Malik ST, Stamp GW, Jobling T, Balkwill FR. In situ detection of tumour necrosis factor in human ovarian cancer specimens. Eur J Cancer 1990;26:1027-30.
23. Malik ST, Naylor MS, East N, Oliff A, Balkwill FR. Cells secreting tumour necrosis factor show enhanced metastasis in nude mice. Eur J Cancer 1990;26:1031-4.
24. Bani MR, Garofalo A, Scanziani E, Giavazzi R. Effect of interleukin-1-beta on metastasis formation in different tumor systems. J Natl Cancer Inst 1991;83:119-23.
25. Arguello F, Baggs RB, Graves BT, Harwell SE, Cohen HJ, Frantz CN. Effect of IL-1 on experimental bone/bone-marrow metastases. Int J Cancer 1992;52:802-7.
26. Kelly SA, Gschmeissner S, East N, Balkwill FR. Enhancement of metastatic potential by γ-interferon. Cancer Res 1991;51:4020-7.
27. Eda H, Fujimoto K, Watanabe S, Ura M, Hino A, Tanaka Y, Wada K, Ishitsuka H. Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5′-deoxy-5-fluorouridine. Cancer Chemother Pharmacol 1993;32:333-8.