Potent hypocholesterolemic activity of the yeast Kluyveromyces marxianus YIT 8292 in rats fed a high cholesterol diet

Bioscience, Biotechnology and Biochemistry

Volumn 68, Issue 6, 2004, Pages 1185-1192

  Yoshida, Yasuto ^a   Yokoi, Wakae ^a   Wada, Yasue ^a   Ohishi, Kenji ^a   Ito, Masahiko ^a   Sawada, Haruji ^a  

^a YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

Author keywords

Cholesterol; Hypercholesterolemia; Kluyveromyces marxianus; Rats; Yeast

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; PHOSPHOLIPID; TRIACYLGLYCEROL;

ANIMAL; ARTICLE; BLOOD; CHEMISTRY; COMPARATIVE STUDY; DIET SUPPLEMENTATION; DIET THERAPY; HYPERCHOLESTEROLEMIA; KLUYVEROMYCES; LIVER; MALE; RAT; WISTAR RAT; YEAST;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; CHOLESTEROL, HDL; DIETARY SUPPLEMENTS; HYPERCHOLESTEROLEMIA; KLUYVEROMYCES; LIVER; MALE; PHOSPHOLIPIDS; RATS; RATS, WISTAR; TRIGLYCERIDES; YEASTS;

KLUYVEROMYCES; KLUYVEROMYCES MARXIANUS; RATTUS NORVEGICUS;

EID: 4544277911     PISSN: 09168451     EISSN: None     Source Type: Journal    
DOI: 10.1271/bbb.68.1185     Document Type: Article

References (36)

1. Kannel, W. B., Castelli, W. P., Gordon, T., and McNamara, P. M., Serum cholesterol, lipoproteins and the risk of coronary heart disease: the Framingham study. Ann. Intern. Med., 74, 1-12 (1971).
2. Martin, M. J., Hulley, S. B., Browner, W. S., Kuller, L. H., and Wentworth, D., Serum cholesterol, blood pressure and mortality: implications from a cohort of 361,662 men. Lancet, 2, 933-936 (1986).
3. Badimon, J. J., Fuster, V., Chesebro, J. H., and Badimon, L., Coronary atherosclerosis: A multifactorial disease. Circulation, 87 (Suppl. II), 3-16 (1993).
4. McCarthy, P. A., New approaches to atherosclerosis: an overview. Med. Res. Rev., 13, 139-159 (1993).
5. Anderson, J. W., Dietary fiber, lipids and atherosclerosis. Am. J. Cardiol., 60, 17G-22G (1987).
6. Thurnham, D. I., Functional foods: cholesterol-lowering benefits of plant sterols. Br. J. Nutr., 82, 255-256 (1999).
7. Rajendran, S., Deepalakshmi, P. D., Parasakthy, K., Devaraj, H., and Devaraj, S. N., Effect of tincture of Crataegus on the LDL-receptor activity of hepatic plasma membrane of rats fed an atherogenic diet. Atherosclerosis, 123, 235-241 (1996).
8. Robbins, E. A., and Seeley, R. D., Cholesterol lowering effect of dietary yeast and yeast fractions. J. Food Sci., 42, 694-698 (1977).
9. Robbins, E. A., and Seeley, R. D., U. S. Patent 4251519 (Jul. 30, 1979).
10. Ebihara, K., and Kiriyama, S., Plasma cholesterol-normalizing activity of brewer's yeast and its various components in rats. Nutr. Rep. Int., 28, 861-871 (1983).
11. Offenbacher, E. G., and Pi-Sunyer, F. X., Beneficial effect of chromium-rich yeast on glucose tolerance and blood lipids in elderly subjects. Diabetes, 29, 919-925 (1980).
12. Elwood, J. C., Nash, D. T., and Streeten, D. H., Effect of high-chromium brewer's yeast on human serum lipids. J. Am. Coll. Nutr., 1, 263-274 (1982).
13. Wang, M. M., Fox, E. A., Stoeker, B. J., Menendez, C. E., and Chan, S. B., Serum cholesterol of adults supplemented with brewer's yeast or chromium chloride. Nutr. Res., 9, 989-998 (1989).
14. Dziekak, J. D., Yeast and yeast derivatives; definitions, characteristics and processing. Food Technol., 2, 104-120 (1987).
15. Nicolosi, R., Bell, S. J., Bistrian, B. R., Greenberg, I., Forse, R. A., and Blackburn, G. L., Plasma lipid changes after supplementation with β-glucan fiber from yeast. Am. J. Clin. Nutr., 70, 208-212 (1999).
16. Mifuchi, I., Hosoi, M., and Yokokura, T., Promotion of resistance to Ehrlich ascites carcinoma cells by injection of tumor cells mixed with yeast cell wall. Gann, 60, 655-656 (1969).
17. Williams, D. L., Pretus, H. A., McNamee, R. B., Jones, E. L., Ensley, H. E., and Browder, I. W., Development of a water-soluble, sulfated (1 → 3)-β-D-glucan biological response modifier derived from S. cerevisiae. Carbohydr. Res., 235, 247-257 (1992).
18. Nakamura, T., Agata, K., Mizutani, M., and Iino, H., Effects of brewer's yeast cell wall on constipation and defecation in experimentally constipated rats. Biosci. Biotechnol. Biochem., 65, 774-780 (2001).
19. Rabinowitz, M. B., Gonick, H. C., Levin, S. R., and Davidson, M. B., Effects of chromium and yeast supplements on carbohydrate and lipid metabolism in diabetic men. Diabetes Care, 6, 319-327 (1983).
20. Offenbacher, E. G., Rinko, C. J., and Pi-Sunyer, F. X., The effects of inorganic chromium and brewer's yeast on glucose tolerance, plasma lipids, and plasma chromium in elderly subjects. Am. J. Clin. Nutr., 42, 454-461 (1985).
21. Li, Y. C., Effects of brewer's yeast on glucose tolerance and serum lipids in Chinese adults. Biol. Trace. Elem. Res., 41, 341-347 (1994).
22. Trow, L. G., Lewis, J., Greenwood, R. H., Sampson, M. J., Self, K. A., Crews, H. M., and Fairweather-Tait, S. J., Lack of effect of dietary chromium supplementation on glucose tolerance, plasma insulin and lipoprotein levels in patients with type 2 diabetes. Int. J. Vitam. Nutr. Res., 70, 14-18 (2000).
23. Association of Official Analytical Chemists Official Methods of Analysis, 15th ed., AOAC, Arlington, VA (1990).
24. Allain, C. C., Poon, L. S., Chan, C. S., Richmond, W., and Fu, P. C., Enzymatic determination of total serum cholesterol. Clin. Chem., 20, 470-475 (1974).
25. Finley, P. R., Schifman, R. B., Williams, R. J., and Lichti, D. A., Cholesterol in high-density lipoprotein: use of Mg2+/dextran sulfate in its enzymic measurement. Clin. Chem., 24, 931-933 (1978).
26. Spayd, R. W., Bruschi, B., Burdick, B. A., Dappen, G. M., Eikenberry, J. N., Esders, T. W., Figueras, J., Goodhue, C. T., LaRossa, D. D., Nelson, R. W., Rand, R. N., and Wu, T. W., Multilayer film elements for clinical analysis: applications to representative chemical determinations. Clin. Chem., 24, 1343-1350 (1978).
27. Takayama, M., Itoh, S., Nagasaki, T., and Tanimizu, I., A new enzymatic method for determination of serum choline-containing phospholipids. Clin. Chim. Acta, 79, 93-98 (1977).
28. Folch, J., Lees, M., and Sloane-Stanley, G. H., A simple method for the isolation and purification of total lipides from animal tissue. J. Biol. Chem., 226, 497-509 (1957).
29. Guermani-Nicolle, L., Villaume, C., Bau, H. M., Schwertz, A., Nicolas, J. P., and Mejean, L., The cholesterol-lowering property of soybeans fed to rats is related to the fasting duration. Plant Foods Hum. Nutr., 56, 239-249 (2001).
30. Anderson, J. W., Davidson, M. H., Blonde, L., Brown, W. V., Howard, W. J., Ginsberg, H., Allgood, L. D., and Weingand, K. W., Long-term cholesterol-lowering effects of psyllium as an adjunct to diet therapy in the treatment of hypercholesterolemia. Am. J. Clin. Nutr., 71, 1433-1438 (2000).
31. Bokura, H., and Kobayashi, S., Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial. Eur. J. Clin. Nutr., 57, 721-725 (2003).
32. Cerda, J. J., Robbins, F. L., Burgin, C. W., Baumgartner, T. G., and Rice, R. W., The effects of grapefruit pectin on patients at risk for coronary heart disease without altering diet or lifestyle. Clin. Cardiol., 11, 589-594 (1988).
33. Terpstra, A. H., Lapre, J. A., de Vries, H. T., and Beynen, A. C., Hypocholesterolemic effect of dietary psyllium in female rats. Ann. Nutr. Metab., 44, 223-228 (2000).
34. Sugano, M., Fujikawa, T., Hiratsuji, Y., Nakashima, K., Fukuda, N., and Hasegawa, Y., A novel use of chitosan as a hypocholesterolemic agent in rats. Am. J. Clin. Nutr., 33, 787-793 (1980).
35. Judd, P. A., and Truswell, A. S., The hypocholesterolaemic effects of pectins in rats. Br. J. Nutr., 53, 409-425 (1985).
36. Belem, M. A. F., and Lee, B. H., Production of bioingredients from Kluyveromyces marxianus grown on whey: an alternative. Crit. Rev. Food Sci. Nutr., 38, 565-598 (1998).