Inhibition of the metabolism of etizolam by itraconazole in humans: Evidence for the involvement of CYP3A4 in etizolam metabolism

European Journal of Clinical Pharmacology

Volumn 60, Issue 6, 2004, Pages 427-430

  Araki, K ^a   Yasui Furukori, N ^b   Fukasawa, T ^a   Aoshima, T ^a   Suzuki, A ^a   Inoue, Y ^c   Tateishi, T ^b   Otani, K ^a  

^a YAMAGATA UNIVERSITY   (Japan)

^b HIROSAKI UNIVERSITY   (Japan)

^c Mitsubishi Pharma   (Japan)

Author keywords

CYP3A4; Etizolam; Itraconazole

Indexed keywords

ETIZOLAM; ITRACONAZOLE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; ENZYME INHIBITION; ENZYME MECHANISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; PSYCHOMOTOR PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; SOMNOLENCE;

ADULT; ANTIFUNGAL AGENTS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; CYTOCHROME P-450 ENZYME SYSTEM; DIAZEPAM; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; HALF-LIFE; HUMANS; ITRACONAZOLE; MALE; TRANQUILIZING AGENTS;

EID: 4544275929     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-004-0789-1     Document Type: Article

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