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Volumn 126, Issue 39, 2004, Pages 12291-12297

Analysis of the conserved P9=G10.1 meta-binding motif in hammerhead ribozymes with an extra nucleotide inserted between A9 and G10.1 residues

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CATALYSIS; CATALYST ACTIVITY; ENZYME KINETICS;

EID: 4544271717     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja049634m     Document Type: Article
Times cited : (14)

References (85)
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    • (1993) Science , vol.261 , pp. 709-714
    • Pyle, A.M.1
  • 29
    • 0023221419 scopus 로고
    • (a) Uhlenbeck, O. C. Nature 1987, 328, 596-600.
    • (1987) Nature , vol.328 , pp. 596-600
    • Uhlenbeck, O.C.1
  • 69
    • 0029949701 scopus 로고    scopus 로고
    • (e) McKay, D. B. RNA 1996, 2, 395-403.
    • (1996) RNA , vol.2 , pp. 395-403
    • McKay, D.B.1
  • 83
    • 4644326295 scopus 로고    scopus 로고
    • note
    • In our recent NMR studies by using the metal-binding motif of A9/G10.1 site (ref 11c,d), we found that the substitution of the oxygen atom with a sulfur atom at pro-Rp position of A9 (P9 site) could change the conformation of the natural ribozyme and this conformational change may cause the reduction of the catalytic activity (Suzumura et al., manuscript in preparation). This NMR study casts a question as to the important role of pro-Rp oxygen.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.