Practical aspects of fast HPLC separations for pharmaceutical process development using monolithic columns

Analytica Chimica Acta

Volumn 523, Issue 2, 2004, Pages 149-156

  Wu, Naijun ^a   Dempsey, Jillian ^b   Yehl, Peter M ^a   Dovletoglou, Angelos ^a   Ellison, Dean ^a   Wyvratt, Jean ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Fast separation; High efficiency; Monolithic and packed columns; Pharmaceuticals; Process development; Reversed phase liquid chromatography

Indexed keywords

MONOLITHIC COLUMNS; REACTION MIXTURES; TAILING FACTORS;

COMPUTATIONAL COMPLEXITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MATRIX ALGEBRA; PARAMETER ESTIMATION;

DRUG PRODUCTS;

BENZENE DERIVATIVE; DRUG;

ANALYTICAL EQUIPMENT; ARTICLE; COLUMN CHROMATOGRAPHY; CRYSTALLIZATION; LIQUID; PRESSURE; PRIORITY JOURNAL; PRODUCTIVITY; REPRODUCIBILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SAMPLE; SEPARATION TECHNIQUE; STATISTICAL SIGNIFICANCE;

EID: 4544264740     PISSN: 00032670     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aca.2004.07.069     Document Type: Article

References (27)

1. U.D. Neue, J.L. Carmody, Y.F. Cheng, Z. Lu, C.H. Phoebe, and T.E. Weat Advances in Chromatography 2001 Marcel Dekker New York
2. F. Anitia, and Cs. Horváth J. Chromatogr. A 435 1988 1 15
3. J.D. Thompson, and P.W. Carr Anal. Chem. 74 2002 4150 4159
4. B. Yan, J. Zhao, J.S. Brown, J.S. Blackwell, and P.W. Carr Anal. Chem. 72 2000 1253 1262
5. N. Wu, Q. Tang, A.J. Lippert, and M.L. Lee J. Microcolumn Sep. 13 2001 41 47
6. H. Chen, and Cs. Horváth J. Chromatogr. A 705 1995 3 20
7. J.E. MacNair, K.C. Lewis, and J.W. Jorgenson Anal. Chem. 69 1997 983 989
8. N. Wu, D.C. Collins, J.A. Lippert, Y. Xiang, and M.L. Lee J. Microcolumn Sep. 12 2000 463 469
9. N. Wu, J.A. Lippert, and M.L. Lee J. Chromatogr. A 911 2001 1 12
10. Y. Xian, N. Wu, A.J. Lippert, and M.L. Lee Chromatographia 55 2002 399 403
11. I. Halász, R. Endele, and J. Asshauer J. Chromatogr. A 112 1975 37 60
12. W.D. Ross, and R.T. Jefferson J. Chromatogr. Sci. 8 1970 386 395
13. L.C. Hansen, and R.E. Sievers J. Chromatogr. 99 1974 123 140
14. M. Kele, and G. Guichon J. Chromatogr. A 960 2002 19 49
15. N. Tanaka, H. Kobayashi, N. Ishizuka, H. Minakuchi, K. Nakanishi, K. Hosoya, and T. Ikegami J. Chromatogr. A 965 2002 35 49
16. D.V. McCalley J. Chromatogr. A 965 2002 51 64
17. G.J. Dear, D.N. Mallett, D.M. Higton, A.D. Roberts, S.A. Bird, H. Young, R.S. Plumb, and I.M. Ismail Chromatographia 55 2002 177 184
18. L. Spoof, and J. Meriluoto J. Chromatogr. A 947 2002 237 245
19. J. Wu, H. Zeng, Y. Deng, and S.E. Unger Rapid Commun. Mass Spectrom. 15 2001 1113 1119
20. N. Barbarin, D.B. Mawhinney, R. Black, and J. Henion J. Chromatogr. 783 2003 73 83
21. Y. Hsieh, G.F. Wang, Y.G. Wang, S. Chackalamannil, and W.A. Kortmacher Anal. Chem. 75 2003 1812 1818
22. Y. Hsieh, G.F. Wang, Y.G. Wang, S. Chackalamannil, J.M. Brisson, K. Ng, and W.A. Korfmacher Rapid Commun. Mass Spectrom. 16 2002 944 950
23. http://www.ich.org/ich5q.html: Q3B (R): Impurities in New Drug Products (revised guideline).
24. J.P. Foley, and J.G. Dorsey Anal. Chem. 55 1983 730
25. M. Kele, and G. Guichon J. Chromatogr. A 830 1999 41 54
26. F.C. Leinweber, and U. Tallarek J. Chromatogr. A 1006 2003 207 228
27. A.M. Siouffi J. Chromatogr. A 1000 2003 808 818