Pancreatic carcinoma with brain metastases: Case report and literature review

Digestive and Liver Disease

Volumn 36, Issue 5, 2004, Pages 355-360

  El Kamar, F G ^a   Jindal, K ^a   Grossbard, M L ^a,b   Mizrachi, H H ^c   Kozuch, P S ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b BETH ISRAEL MEDICAL CENTER   (United States)

^c White Plains Hospital Center   (United States)

Author keywords

Brain metastases; Chemotherapy; Gemcitabine; Pancreatic cancer

Indexed keywords

CA 19-9 ANTIGEN; CISPLATIN; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; IRINOTECAN; ANTINEOPLASTIC AGENT;

ADULT; ARTICLE; BRAIN BIOPSY; BRAIN METASTASIS; CANCER MORTALITY; CANCER STAGING; CASE REPORT; CLINICAL FEATURE; DETERIORATION; DYSARTHRIA; GAIT DISORDER; HAND MUSCLE; HEMISPHERE; HUMAN; MALE; MEDICAL LITERATURE; MUSCLE WEAKNESS; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; NYSTAGMUS; PANCREAS CARCINOMA; PONS; ADENOCARCINOMA; BRAIN TUMOR; FATALITY; LIVER TUMOR; METASTASIS; MIDDLE AGED; PANCREAS TUMOR; PATHOLOGY; REVIEW;

ADENOCARCINOMA; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BRAIN NEOPLASMS; FATAL OUTCOME; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS;

EID: 4544249743     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2003.10.019     Document Type: Article

References (26)

1. Kozuch P, Grossbard ML, Barzdins A, Araneo M, Robin A, Frager D, et al. Irinotecan combined with gemcitabine, 5-fluorouracil, leucovorin and cisplatin (G-FLIP) is an effective and noncrossresistant treatment for chemotherapy refractory metastatic pancreatic cancer. Oncologist 2001;6:488-95.
2. El Kamar FG, Bruckner HW, Jindal K, Homel P, Kozuch P. Irinotecan combined with gemcitabine, 5-FU (5-fluorouracil), LV (leucovorin), and cisplatin (G-FLIP) is an effective first line regimen for metastatic adenocarcinoma of the exocrine pancreas (MPAC). Pancreas 2001;23:428-69. Abstract F435.
3. Scheinker I. Pathology and symptoms of diffuse carcinomatosis. Monat f Psych u Neurol 1939;101:275.
4. Uspensky E. On diffuse carcinomatous metastases in the nervous system. J Neuropathol Exp Neurol 1943;2:103.
5. Jacobs LL, Richland KJ. Carcinomatosis of the Leptomeninges-Review of Literature and report of four cases. Bull Los Angeles Neurol Soc 1951;16:335-56.
6. Little JR, Dale AJ, Okazaki H. Meningeal carcinomatosis. Clinical manifestations. Arch Neurol 1974;30:138-43.
7. Tavares A, Serrao D. On the metastatic spread of carcinoma of the pancreas. J Med (Oporto) 1965;57:65-70.
8. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 12-1972. N Engl J Med 1972;286:650-6.
9. Olson ME, Chernik NL, Posner JB. Infiltration of the leptomeninges by systemic cancer. A clinical and pathologic study. Arch Neurol 1974;30:122-37.
10. Leech RW, Welch FT, Ojemann GA. Subdural hematoma secondary to metastatic dural carcinomatosis. Case report. J Neurosurg 1974;41:610-3.
11. Galatioto S, Savettieri G. Meningeal carcinomatosis secondary to a primary pancreatic tumor. Anatoma-clinical study. Acta Neurol 1975;30:359-67.
12. Ferreira Montero V, Eiras Ajuria J, Gomez Pereda R, Montori Lasilla M, Valero Palomero MI. Cerebral metastasis, idiopathic pneumoperitoneum and obstructive jaundice as clinical manifestations of carcinoma of the pancreas. Rev Esp Oncol 1983;30:399-409.
13. Lee YT, Tatter D. Carcinoma of the pancreas and periampullary structures. Pattern of metastasis at autopsy. Arch Pathol Lab Med 1984;108:584-7.
14. Shangai VA, Gavrik IuV. Metastasis of pancreatic cancer to the brain. Vrach Delo 1984;77-9.
15. Ara-Callizo JR, Gimenez-Mas JA, Martin J, Lacasa J. Calcified brain metastases from acinar-cell carcinoma of pancreas. Neuroradiology 1989;31:200.
16. Kawahata N, Ohtomo E. Metastatic brain tumor in the elderly. Rinsho Shinkeigaku 1989;29:1106-9.
17. Le Cesne A, Le Chevalier T, Caille P, Cvitkovic E, Contesso G, Spielmann M, et al. Metastases from cancers of unknown primary site. Data from 302 autopsies. Presse Med 1991;20:1369-73.
18. Yamada K, Miura M, Miyayama H, Sakashita N, Kochi M, Ushio Y. Brain metastases from asymptomatic adenocarcinoma of the pancreas: an autopsy case report. Surg Neurol 2002;58:332-6. Discussion 336-7.
19. Demchuk AI. Clinical picture and diagnosis of metastatic brain cancer with its primary source in the pancreas. Vrach Delo 1977;38-41.
20. Kuratsu J, Murakami M, Uemura S, Ushio Y. Brain and skull metastases of hepatic or pancreatic cancer-report of six cases. Neurol Med Chir 1990;30:476-82.
21. Ohira Y, Kaga K, Kodama A. A case of bilateral sudden hearing loss and vertigo caused by bilateral temporal bone metastasis from pancreatic carcinoma-comparison of clinical findings and temporal bone pathological findings. Nippon Jibiinkoka Gakkai Kaiho 1991;94:9-15.
22. Castillo J, Ascaso FJ, Aguelo JM, Minguez E, Cristobal JA, Palomar A. Bilateral choroidal metastases of pancreatic carcinoma. J Fr Ophtalmol 1995;18:795-8.
23. Ferreira Filho AF, Cardoso F, Di Leo A, Awada A, da Silva VD, Tovar RB, et al. Carcinomatous meningitis as a clinical manifestation of pancreatic carcinoma. Ann Oncol 2001;12:1757-9.
24. Tsuji Y, Ohigashi H, Ishikawa O, Yasuda T, Nakano H, Nakamori S, et al. A case of non resectable pancreatic cancer surviving more than 4 years by intra-arterial infusion with angiotensin-II. Gan To Kagatu Ryoho 1996;23:1617-20.
25. Park KS, Kim M, Park SH, Lee KW. Nervous system involvement by pancreatic cancer. J Neurooncol 2003;63:313-6.
26. Falconi M, Mantovani W, Bettini R, Talamini G, Bassi C, Cascinu S. Carcinoma of pancreatic body and tail: are there improvements in diagnosis and treatment modalities over the past decade? Dig Liver Dis 2003;35:421-7.