Synthesis and cytotoxic activity of 4-substituted 3-cyano-6,6-dimethyl-5,6- dihydro-2-pyranones

Chemistry of Heterocyclic Compounds

Volumn 40, Issue 6, 2004, Pages 715-724

  Leite, L ^a   Jansone, D ^a   Fleisher, M ^a   Kazhoka, H ^a   Popelis, J ^a   Veretennikova, N ^a   Shestakova, I ^a   Domracheva, I ^a   Lukevics, E ^a  

^a LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

Author keywords

benzaldehyde; crotonic condensation mechanism; cytotoxic activity; OREX expert system; semiempirical AM1 method; substituted lactones

Indexed keywords

3 CYANO 4,6,6 TRIMETHYL 5,6 DIHYDRO 2 PYRANONE; BENZALDEHYDE; CYTOTOXIC AGENT; KETONE DERIVATIVE; LACTONE DERIVATIVE; SODIUM HYDROXIDE; UNCLASSIFIED DRUG;

CATALYSIS; CONFERENCE PAPER; CYTOTOXICITY; MICHAEL ADDITION; POLYMERIZATION; SYNTHESIS;

EID: 4544233628     PISSN: 00093122     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:COHC.0000040766.10102.81     Document Type: Conference Paper

References (11)

1. L. Leite, D. Jansone, M. Veveris, H. Cirule, Y. Popelis, G. Melikyan, A. Avetisyan, and E. Lukevics, Eur. J. Med. Chem., 34, 859 (1999).
2. A. Perjessy, A. Avetisyan, A. Aknazaryan, and G. Melikyan, Coll. Czech. Chem. Commun., 54, 1666 (1989).
3. M. Fleisher, D. Jansone, G. Andreeva, L. Leite, and E. Lukevics, Khim. Geterotsikl. Soedin., 748 (2001).
4. J. J. P. Stewart, MOPAC Program Package (QCPE N 455) version 6.
5. JMol: http://www.chem.columbia.edu/~gezelter.
6. ChemCraft: http://chemcraft.boom.ru.
7. F. A. Alien, O. Kennard, and D. G. Watson, J. Chem. Soc., Perkin Trans 2, No. 12, S1 (1987).
8. A. Rozenblit and V. Golender, Logic-Combinatorial Methods in Design of Drugs [in Russian], Zinatne, Riga (1983).
9. N. Veretennikova, A. Skorova, V. Kudryashova, A. Rozenblit, A. Barkans, Ya. Betinsh, V. Drboglav, L. Gitlina, Ya. Grinfelds, P. Mellis, D. Petersone, and V. Shatokhin, in: Fei Chen and Gerrit Schuurmann (editors), QSAR in Environmental Sciences - VII, Setac/Setac Foundation (1997), p. 115.
10. D. J. Fast, R. C. Lynch, and R. W. Leu, J. Leucocyt. Biol., 52, 255 (1992).
11. P. J. Freshney, Culture of Animal Cells (A Manual of Basic Technique), Wiley-Liss, New York (1994), p. 296.