Synthesis and antiviral activities of 1′-carbon-substituted 4′-thiothymidines

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 20, 2004, Pages 5309-5316

  Haraguchi, Kazuhiro ^a   Takahashi, Haruhiko ^a   Tanaka, Hiromichi ^a   Hayakawa, Hiroyuki ^b   Ashida, Noriyuki ^b   Nitanda, Takao ^c   Baba, Masanori ^c  

^a SHOWA UNIVERSITY   (Japan)

^b YAMASA CORPORATION   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Glycal; Glycosidation; Lithiation; Nucleoside

Indexed keywords

1 (1 CYANOETHENYL 2 DEOXY 1 FORMYL 4 THIO BETA DEXTRO RIBOFURANOSYL) THYMINE; 1 (2 DEOXY 1 FORMYL 4 THIO BETA DEXTRO RIBOFURANOSYL)THYMINE; 1 (2 DEOXY 1 HYDROXYMETHYL 4 THIO BETA DEXTRO RIBOFURANOSYL)THYMINE; 1 (2 DEOXY 1 METHOXYIMINO 4 THIO BETA DEXTRO RIBOFURANOSYL)THYMINE; 1 (2 DEOXY 1 METHYL 4 THIO BETA DEXTRO RIBOFURANOSYL)THYMINE; 1 (CYANO 2 DEOXY 4 THIO BETA DEXTRO RIBOFURANOSYL)THYMINE; 1 [1 (ACETOXYMETHYL) 2 DEOXY 2 IODO 3,5 O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL) 4 THIO BETA DEXTRO RIBOFURANOSYL]THYMINE; 1 [1 (ACETOXYMETHYL) 2 DEOXY 3,5 O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL) 4 THIO BETA DEXTRO RIBOFURANOSYL]THYMINE; 1 [1 (TERT BUTYLDIMETHYLSILYLOXYMETHYL) 2 DEOXY 2 IODO 3,5 O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL) 4 THIO BETA DEXTRO RIBOFURANOSYL]THYMINE; 1 [1 CYANOETHENYL 2 DEOXY 3,5 O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL) 4 THIO BETA DEXTRO RIBOFURANOSYL]THYMINE; 1 [2 CYANO 2 DEOXY 3,5 O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL) 4 THIO BETA DEXTRO RIBOFURANOSYL]THYMINE; 1 [2 DEOXY 1 FORMYL 3,5 O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL) 4 THIO BETA DEXTRO RIBOFURANOSYL]THYMINE; 1 [2 DEOXY 1 HYDROXYMETHYL 3,5 O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL) 4 THIO BETA DEXTRO RIBOFURANOSYL]THYMINE; 1 [2 DEOXY 1 METHYL 3,5 O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL) 4 THIO BETA DEXTRO RIBOFURANOSYL]THYMINE; 1 [2 DEOXY 2 IODO 1 METHYL 3,5 O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL) 4 THIO BETA DEXTRO RIBOFURANOSYL]THYMINE; 1 ACETOXYMETHYL 1,4 ANHYDRO 2 DEOXY 3,5 O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL) 4 THIO DEXTRO ERYTHRO PENTO 1 ENITOL; 1,4 ANHYDRO 1 (TERT BUTYLDIMETHYLSILYLOXYMETHYL) 2 DEOXY 3,5 O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL) 4 THIO DEXTRO ERYTHRO PENTO 1 ENITOL; 1,4 ANHYDRO 2 DEOXY 1 METHYL 3,5 O (1,1,3,3 TETRAISOPROPYLDISILOXANE 1,3 DIYL) 4 THIO DEXTRO ERYTHRO PENTO 1 ENITOL; ANTIVIRUS AGENT; FURAN DERIVATIVE; IODINE DERIVATIVE; METHYL GROUP; RADICAL; THYMIDINE DERIVATIVE; THYMINE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; ATOM; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; GLYCOSIDATION; HUMAN; HUMAN CELL; LITHIATION; SILYLATION; STEREOCHEMISTRY;

ANTIVIRAL AGENTS; HERPESVIRUS 1, HUMAN; HIV-1; HUMANS; THIONUCLEOSIDES; THYMIDINE;

HUMAN HERPESVIRUS 1;

EID: 4544232905     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.07.057     Document Type: Article

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