Long-term treatment of familial male-limited precocious puberty (testotoxicosis) with cyproterone acetate or ketoconazole

Clinical Endocrinology

Volumn 69, Issue 1, 2008, Pages 93-98

  Almeida, Madson Queiroz ^a   Brito, Vinicius Nahime ^a   Lins, Thereza Selma S ^b   Guerra Jr , Gil ^c   De Castro, Margaret ^a   Antonini, Sonir Roberto ^a   Arnhold, Ivo Jorge Prado ^a   Mendonca, Berenice Bilharinho ^a   Latronico, Ana Claudia ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Instituto Materno Infantil   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CYPROTERONE ACETATE; GONADORELIN; GONADOTROPIN; KETOCONAZOLE; LUTEINIZING HORMONE RECEPTOR; TESTOSTERONE;

ARTICLE; BODY HEIGHT; BONE AGE; BRAZIL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FAMILIAL DISEASE; FREQUENCY ANALYSIS; GENE MUTATION; GONADOTROPIN BLOOD LEVEL; GROWTH RATE; HUMAN; LONG TERM CARE; MALE; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STATISTICAL SIGNIFICANCE; TESTOSTERONE BLOOD LEVEL; TESTOTOXICOSIS; TREATMENT DURATION; TREATMENT OUTCOME;

EID: 45349101630     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2007.03160.x     Document Type: Article

References (33)

1. Shenker, A., Laue, L., Kosugi, S., Merendino, J.J. Jr., Minegishi, T. Cutler, G.B. Jr. (1993) A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature, 365, 652 654.
2. Schedewie, H.K., Reiter, E.O., Beitins, I.Z., Seyed, S., Wooten, V.D., Jimenez, J.F., Aiman, E.J., DeVane, G.W., Redman, J.F. Elders, M.J. (1981) Testicular leydig cell hyperplasia as a cause of familial sexual precocity. Journal of Clinical Endocrinology and Metabolism, 52, 271 278.
3. Latronico, A.C., Lins, T.S., Brito, V.N., Arnhold, I.J. Mendonca, B.B. (2000) The effect of distinct activating mutations of the luteinizing hormone receptor gene on the pituitary-gonadal axis in both sexes. Clinical Endocrinology, 53, 609 613.
4. Latronico, A.C. Segaloff, D.L. (1999) Naturally occurring mutations of the luteinizing-hormone receptor: lessons learned about reproductive physiology and G protein-coupled receptors. American Journal of Human Genetics, 65, 949 958.
5. Itoh, K., Nakada, T., Kubota, Y., Suzuki, H., Ishigooka, M. Izumi, T. (1996) Testotoxicosis proved by immunohistochemical analysis and successfully treated with cyproterone acetate. Urologia Internationalis, 57, 199 202.
6. Bertelloni, S., Baroncelli, G.I., Lala, R., Cappa, M., Matarazzo, P., De Sanctis, C. Saggese, G. (1997) Long-term outcome of male-limited gonadotropin-independent precocious puberty. Hormone Research, 48, 235 239.
7. Leschek, E.W., Jones, J., Barnes, K.M., Hill, S.C. Cutler, G.B. Jr. (1999) Six-year results of spironolactone and testolactone treatment of familial male-limited precocious puberty with addition of deslorelin after central puberty onset. Journal of Clinical Endocrinology and Metabolism, 84, 175 178.
8. Kreher, N.C., Pescovitz, O.H., Delameter, P., Tiulpakov, A. Hochberg, Z. (2006) Treatment of familial male-limited precocious puberty with bicalutamide and anastrozole. Journal of Pediatrics, 149, 416 420.
9. Soriano-Guillen, L., Lahlou, N., Chauvet, G., Roger, M., Chaussain, J.L. Carel, J.C. (2005) Adult height after ketoconazole treatment in patients with familial male-limited precocious puberty. Journal of Clinical Endocrinology and Metabolism, 90, 147 151.
10. Neumann, F. (1971) Use of cyproterone acetate in animal and clinical trials. Gynecologic Investigation, 2, 150 179.
11. Kauli, R., Prager-Lewin, R., Keret, R. Laron, Z. (1975) The LH response to LH releasing hormone in children with true isosexual precocious puberty treated with cyproterone acetate. Clinical Endocrinology, 4, 305 311.
12. Laron, Z. Kauli, R. (2000) Experience with cyproterone acetate in the treatment of precocious puberty. Journal of Pediatric Endocrinology and Metabolism, 13 (Suppl. 1 805 810.
13. Feuillan, P., Calis, K., Hill, S., Shawker, T., Robey, P.G. Collins, M.T. (2007) Letrozole treatment of precocious puberty in girls with the McCune-Albright syndrome; a pilot study. Journal of Clinical Endocrinology and Metabolism, 92, 2100 2106.
14. Mieszczak, J. Eugster, E.A. (2007) Treatment of precocious puberty in McCune-Albright syndrome. Pediatric Endocrinology Reviews, 4 (Suppl. 4 419 422.
15. Holland, F.J., Fishman, L., Bailey, J.D. Fazekas, A.T. (1985) Ketoconazole in the management of precocious puberty not responsive to LHRH-analogue therapy. New England Journal of Medicine, 312, 1023 1028.
16. Babovic-Vuksanovic, D., Donaldson, M.D., Gibson, N.A. Wallace, A.M. (1994) Hazards of ketoconazole therapy in testotoxicosis. Acta Paediatrica, 83, 994 997.
17. Evans, B.A., Bowen, D.J., Smith, P.J., Clayton, P.E. Gregory, J.W. (1996) A new point mutation in the luteinising hormone receptor gene in familial and sporadic male limited precocious puberty: genotype does not always correlate with phenotype. Journal of Medical Genetics, 33, 143 147.
18. Latronico, A.C., Anasti, J., Arnhold, I.J., Mendonca, B.B., Domenice, S., Albano, M.C., Zachman, K., Wajchenberg, B.L. Tsigos, C. (1995) A novel mutation of the luteinizing hormone receptor gene causing male gonadotropin-independent precocious puberty. Journal of Clinical Endocrinology and Metabolism, 80, 2490 2494.
19. Latronico, A.C., Abell, A.N., Arnhold, I.J., Liu, X., Lins, T.S., Brito, V.N., Billerbeck, A.E., Segaloff, D.L. Mendonca, B.B. (1998) A unique constitutively activating mutation in third transmembrane helix of luteinizing hormone receptor causes sporadic male gonadotropin-independent precocious puberty. Journal of Clinical Endocrinology and Metabolism, 83, 2435 2440.
20. Latronico, A.C., Shinozaki, H., Guerra, G. Jr., Pereira, M.A., Lemos Marini, S.H., Baptista, M.T., Arnhold, I.J., Fanelli, F., Mendonca, B.B. Segaloff, D.L. (2000) Gonadotropin-independent precocious puberty due to luteinizing hormone receptor mutations in Brazilian boys: a novel constitutively activating mutation in the first transmembrane helix. Journal of Clinical Endocrinology and Metabolism, 85, 4799 4805.
21. Teles, M., Brito, V.N., Arnhold, I.J., Mendonca, B.B. Latronico, A.C. (2006) Preclinical diagnosis of testotoxicosis in a boy with an activating mutation of the luteinizing hormone receptor. Journal of Pediatric Endocrinology and Metabolism, 19, 541 544.
22. Greulich, W.W. Pyle, S.I. (1985) Radiographic Skeletal Development of the Hand and Wrist. Stanford University Press, Stanford.
23. Bayley, N. Pinneau, S.R. (1952) Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. Journal of Pediatrics, 40, 423 441.
24. Tanner, J.M., Goldstein, H. Whitehouse, R.H. (1970) Standards for children's height at ages 2-9 years allowing for heights of parents. Archives of Disease in Childhood, 45, 755 762.
25. Cavallo, A., Richards, G.E., Busey, S. Michaels, S.E. (1995) A simplified gonadotrophin-releasing hormone test for precocious puberty. Clinical Endocrinology, 42, 641 646.
26. Brito, V.N., Batista, M.C., Borges, M.F., Latronico, A.C., Kohek, M.B., Thirone, A.C., Jorge, B.H., Arnhold, I.J. Mendonca, B.B. (1999) Diagnostic value of fluorometric assays in the evaluation of precocious puberty. Journal of Clinical Endocrinology and Metabolism, 84, 3539 3544.
27. Laue, L., Chan, W.Y., Hsueh, A.J., Kudo, M., Hsu, S.Y., Wu, S.M., Blomberg, L. Cutler, G.B. Jr. (1995) Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty. Proceedings of the National Academy of Sciences of the United States of America, 92, 1906 1910.
28. Muller, J., Gondos, B., Kosugi, S., Mori, T. Shenker, A. (1998) Severe testotoxicosis phenotype associated with Asp578→Tyr mutation of the lutrophin/choriogonadotrophin receptor gene. Journal of Medical Genetics, 35, 340 341.
29. Laue, L., Kenigsberg, D., Pescovitz, O.H., Hench, K.D., Barnes, K.M., Loriaux, D.L. Cutler, G.B. Jr. (1989) Treatment of familial male precocious puberty with spironolactone and testolactone. New England Journal of Medicine, 320, 496 502.
30. Laue, L., Jones, J., Barnes, K.M. Cutler, G.B. Jr. (1993) Treatment of familial male precocious puberty with spironolactone, testolactone, and deslorelin. Journal of Clinical Endocrinology and Metabolism, 76, 151 155.
31. Soriano-Guillen, L., Mitchell, V., Carel, J.C., Barbet, P., Roger, M. Lahlou, N. (2006) Activating mutations in the luteinizing hormone receptor gene: a human model of non-follicle-stimulating hormone-dependent inhibin production and germ cell maturation. Journal of Clinical Endocrinology and Metabolism, 91, 3041 3047.
32. Boepple, P.A., Frisch, L.S., Wierman, M.E., Hoffman, W.H. Crowley, W.F. Jr. (1992) The natural history of autonomous gonadal function, adrenarche, and central puberty in gonadotropin-independent precocious puberty. Journal of Clinical Endocrinology and Metabolism, 75, 1550 1555.
33. Hayes, F.J., Seminara, S.B., Decruz, S., Boepple, P.A. Crowley, W.F. Jr. (2000) Aromatase inhibition in the human male reveals a hypothalamic site of estrogen feedback. Journal of Clinical Endocrinology and Metabolism, 85, 3027 3035.