Effect of serotonin on small intestinal contractility in healthy volunteers

Physiological Research

Volumn 57, Issue 1, 2008, Pages 63-71

  Hansen, Mark Berner ^a,c   Arif, F ^a   Gregersen, H ^b   Bruusgaard, H ^a   Wallin, L ^a  

^a GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^b AALBORG UNIVERSITY HOSPITAL   (Denmark)

^c BISPEBJERG HOSPITAL   (Denmark)

Author keywords

5 hydroxytryptamine; Blood levels; Human; Intestines; Migrating motor complex; Motility; Physiology; Serotonin

Indexed keywords

SEROTONIN;

ADULT; ARTICLE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG INSTILLATION; DUODENUM; FEMALE; GASTROINTESTINAL MOTILITY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; JEJUNUM; MALE; MIDDLE AGED; MIGRATING MYOELECTRIC COMPLEX; PHYSIOLOGY; REFERENCE VALUE; STOMACH ANTRUM;

ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; DUODENUM; FEMALE; GASTROINTESTINAL MOTILITY; HUMANS; INFUSIONS, INTRAVENOUS; INSTILLATION, DRUG; JEJUNUM; MALE; MIDDLE AGED; MYOELECTRIC COMPLEX, MIGRATING; PYLORIC ANTRUM; REFERENCE VALUES; SEROTONIN;

EID: 45349086741     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. AHLMAN H, NILSSON I: The gut as the largest endocrine organ in the body. Ann Oncol 12 (Suppl 2): S62-S68, 2001.
2. BAKER DE: Rationale for using serotonergic agents to treat irritable bowel syndrome. Am J Health Syst Pharm 62: 700-711, 2005.
3. BERTRAND PP: Real-time detection of serotonin release from enterochromaffin cells of the guinea pig ileum. Neurogastroenterol Motil 16: 511-514, 2004.
4. FERRARA A, ZINNER MJ, HINSDALE JG, JAFFE BM: Intraluminal release of serotonin during the interdigestive migrating complex in the canine small intestine. J Surg Res 41: 308-311, 1986.
5. GERSHON MD: Importance of serotonergic mechanisms in gastrointestinal motility and sensation. In: Irritable Bowel Syndrome. CAMILLERI M, SPILLER RC (eds), WB Saunders, Edinburgh, 2002, pp 95-116.
6. GERSHON MD: Serotonin and its implication for the management of irritable bowel syndrome. Rev Gastroenterol Disord 3 (Suppl 2): S25-S34, 2003.
7. GORARD DA, LIBBY GW, FARTHING MJ: 5-Hydroxytryptamine and human small intestinal motility: effect of inhibiting 5-hydroxytryptamine reuptake. Gut 35: 496-500, 1994.
8. GRONSTAD KO, DAHLSTROM A, JAFFE BM, AHLMAN H: Regional and selective changes in blood flow of the feline small intestine induced by endoluminal serotonin. Acta Physiol Scand 127: 207-213, 1986.
9. GRONSTAD K, DAHLSTROM A, FLORENCE L, ZINNER MJ, AHLMAN J, JAFFE BM: Regulatory mechanisms in endoluminal release of serotonin and substance P from feline jejunum. Dig Dis Sci 32: 393-400, 1987.
10. HAGA N, MIZUMOTO A, SATOH M, MOCHIKI E, MIZUSAWA F, OHSHIMA K, ITOH Z: Role of endogenous 5-hydroxytryptamine in the regulation of gastric contractions by motilin in dogs. Am J Physiol 270: G20-G28, 1996.
11. HANSEN MB: Small intestinal manometry. Physiol Res 51: 541-556, 2002.
12. HANSEN MB: Neurohumoral control of gastrointestinal motility. Physiol Res 52: 1-30, 2003.
13. HANSEN MB, JAFFE BM: 5-HT receptor subtypes involved in luminal serotonin-induced secretion in rat intestine in vivo. J Surg Res 56: 277-287, 1994.
14. HANSEN MB, SKADHAUGE E: Signal transduction pathways for serotonin as an intestinal secretagogue. Comp Biochem Physiol A 118: 283-290, 1997.
15. HANSEN MB, DRESNER LS, WAIT RB: Profile of neurohumoral agents on mesenteric and intestinal blood flow in health and disease. Physiol Res 47: 307-327, 1998.
16. HANSEN MB, ARIF F, WALLIN, PEDERSEN JF: Serotonin and superior mesenteric artery resistance index. Scand J Clin Lab Invest 66: 395-406, 2006.
17. HOUGHTON LA, ATKINSON W, WHITAKER RP, WHORWELL PJ, RIMMER MJ: Increased platelet depleted plasma 5-hydroxytryptamine concentration following meal ingestion in symptomatic female subjects with diarrhoea predominant irritable bowel syndrome. Gut 52: 663-670, 2003.
18. HUSEBYE E: The patterns of small bowel motility: physiology and implications in organic disease and functional disorders. Neurogastroenterol Motil 11: 141-161, 1999.
19. KAUMANN AJ, SANDERS L, BROWN, AM, MURRRAY KJ, BROWN MJ: A 5-HT4-like receptor in human right atrium. Naunyn Schmiedebergs Arch Pharmacol 344: 150-159, 1991.
20. KELLUM JM, Jr., JAFFE BM: Release of immunoreactive serotonin following acid perfusion of the duodenum. Ann Surg 184: 633-636, 1976.
21. KELLUM JM, MAXWELL JD, POTTER J, KUMMERLE JF: Motilin's induction of phasic contractility in canine jejunum is mediated by the luminal release of serotonin. Surgery 100: 445-453, 1986.
22. KILKENS TO, HONIG A, VAN NIEUWENHOVEN MA, RIEDEL WJ, BRUMMER RJ: Acute tryptophan depletion affects brain-gut responses in irritable bowel syndrome patients and controls. Gut 53: 1794-1800, 2004.
23. KOJIMA S: KW-5092, a novel gastrokinetic agent, facilitates luminal serotonin release from the guinea-pig colon. Eur J Pharmacol 374: 113-115, 1999.
24. LORDAL M, HELLSTROM PM: 5-Hydroxytryptamine: initiator of phase 3 of migrating motor complex. Acta Physiol Scand 155: 241-242, 1995.
25. LORDAL M, WALLEN H, HJEMDAHL P, BECK O, HELLSTROM PM: Concentration-dependent stimulation of intestinal phase III of migrating motor complex by circulating serotonin in humans. Clin Sci 94: 663-670, 1998.
26. ORMSBEE HS, SILBER DA, HARDY FE Jr: Serotonin regulation of the canine migrating motor complex. J Pharmacol Exp Ther 231: 436-440, 1984.
27. RACKE K, REIMANN A, SCHWORER H, KILBINGER H: Regulation of 5-HT release from enterochromaffin cells. Behav Brain Res, 73: 83-87, 1996.
28. SAGRADA A, BRANCACCIO N, SCHIAVONE A: 5-Hydroxytryptamine affects rat migrating myoelectric complexes through different receptor subtypes: evidence from 5-hydroxytryptophan administration. Life Sci 46: 1207-1216, 1990.
29. TANAKA T, MIZUMOTO A, MOCHIKI E, HAGA N, SUZUKI H, ITOH Z: Relationship between intraduodenal 5-hydroxytryptamine release and interdigestive contractions in dogs. J Smooth Muscle Res 40: 75-84, 2004.
30. TONINI M: 5-Hydroxytryptamine effects in the gut: the 3, 4, and 7 receptors. NeurogastroenterolMotil 17: 637-642, 2005.
31. VANTRAPPEN G, JANSSENS J, HELLEMANS J, GHOOS Y: The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 59: 1158-1166, 1977.
32. WADE PR, CHEN J, JAFFE B, KASSEM IS, BLAKELY RD, GERSHON MD: Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J Neurosci 16: 2352-2364, 1996.
33. ZINNER MJ, KASHER F, JAFFE BM: The hemodynamic effects of intravenous infusions of serotonin in conscious dogs. J Surg Res, 34: 171-178, 1983.
34. ZHU JX, ZHU XY, OWYANG C, LI Y: Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat. J Physiol Lond 530: 431-442, 2001.