VEGF-induced choroidal damage in a murine model of retinal neovascularisation

British Journal of Ophthalmology

Volumn 92, Issue 6, 2008, Pages 832-838

  Tee, L B G ^a,b   Penrose, M A ^a   O'Shea, J E ^a   Lai, C M ^c   Rakoczy, E P ^c   Dunlop, S A ^a,d  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b CURTIN UNIVERSITY   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOROID; CHOROID DISEASE; CHOROID VASCULARIZATION; DIABETES MELLITUS; DISEASE MODEL; DISEASE SEVERITY; EYE FUNDUS; HUMAN VERSUS ANIMAL COMPARISON; IMMUNOHISTOCHEMISTRY; MICROANEURYSM; MOUSE; MOUSE STRAIN; NONHUMAN; OPHTHALMIC ARTERY; PATHOPHYSIOLOGY; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETINA ANGIOGRAPHY; RETINA BLOOD VESSEL; RETINA NEOVASCULARIZATION; SCANNING ELECTRON MICROSCOPY; SUBRETINAL NEOVASCULARIZATION; TRANSGENIC MOUSE; VASOCONSTRICTION;

ANIMALS; CAPILLARIES; CHOROID; CORROSION CASTING; FLUORESCEIN ANGIOGRAPHY; FUNDUS OCULI; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, SCANNING; MODELS, ANIMAL; PHENOTYPE; PIGMENT EPITHELIUM OF EYE; RETINAL NEOVASCULARIZATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 45249122231     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.2007.130898     Document Type: Article

References (25)

1. Forrester JV, AD D, McMenammin P, et al. The eye: basic sciences in practice. 1st edn. London: WB Saunders; 1996.
2. Shiragami C, Shiraga F, Matsuo T, et al. Risk factors for diabetic choroidopathy in patients with diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 2002;240:436-42.
3. McLeod DS, Lutty GA. High-resolution histologic analysis of the human choroidal vasculature. Invest Ophthalmol Vis Sci 1994;35:3799-811.
4. Lutty GA, Cao J, McLeod DS. Relationship of polymorphonuclear leukocytes to capillary dropout in the human diabetic choroid. Am J Pathol 1997;151:707-14.
5. Schocket LS, Brucker AJ, Niknam RM, et al. Foveolar choroidal hemodynamics in proliferative diabetic retinopathy. Int Ophthalmol 2004;25:89-94.
6. Fryczkowski AW, Hodes BL, Walker J. Diabetic choroidal and iris vasculature scanning electron microscopy findings. Int Ophthalmol 1989;13:269-79.
7. Rodrigues AC, Schellini SA, Gregorio EA, et al. Choroidal vasculature in diabetic rats. J Submicrosc Cytol Pathol 2004;36:327-31.
8. Caldwell RB, Fitzgerald ME. The choriocapillaris in spontaneously diabetic rats. Microvasc Res 1991;42:229-44.
9. Johnson MA, Lutty GA, McLeod DS, et al. Ocular structure and function in an aged monkey with spontaneous diabetes mellitus. Exp Eye Res 2005;80:37-42.
10. Sone H, Kawakami Y, Okuda Y, et al. Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes. Diabetologia 1997;40:726-30.
11. Witmer AN, Vrensen GF, Van Noorden CJ, et al. Vascular endothelial growth factors and angiogenesis in eye disease. Prog Retin Eye Res 2003;22:1-29.
12. Lai CM, Dunlop SA, May LA, et al. Generation of transgenic mice with mild and severe retinal neovascularisation. Br J Ophthalmol 2005;89:911-16.
13. Shen WY, Lai CM, Graham CE, et al. Long-term global retinal microvascular changes in a transgenic vascular endothelial growth factor mouse model. Diabetologia 2006;49:1690-701.
14. van Eeden PE, Tee LB, Lukehurst S, et al. Early vascular and neuronal changes in a VEGF transgenic mouse model of retinal neovascularization. Invest Ophthalmol Vis Sci 2006;47:4638-45.
15. Dunlop SA, Moore SR, Beazley LD. Changing patterns of vasculature in the developing amphibian retina. J Exp Biol 1997;200:2479-92.
16. Miyamoto K, Khosrof S, Bursell SE, et al. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci USA 1999;96:10836-41.
17. Moore J, Bagley S, Ireland G, et al. Three dimensional analysis of microaneurysms in the human diabetic retina. J Anat 1999;194:89-100.
18. Tobe T, Okamoto N, Vinores MA, et al. Evolution of neovascularization in mice with overexpression of vascular endothelial growth factor in photoreceptors. Invest Ophthalmol Vis Sci 1998;39:180-8.
19. Okamoto N, Tobe T, Hackett SF, et al. Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization. Am J Pathol 1997;151:281-91.
20. Metelitsina T, Grunwald J, DuPont J, et al. Foveolar choroidal circulation and choroidal neovascularization in age-related macular degeneration. Invest Ophthalmol Vis Sci 2008;49:358-63.
21. Lu ZY, Bhutto IA, Amemiya T. Retinal changes in Otsuka Long-Evans Tokushima Fatty rats (spontaneously diabetic rat) - possibility of a new experimental model for diabetic retinopathy. Jpn J Ophthalmol 2003;47:28-35.
22. Bhutto IA, Lu ZY, Takami Y, et al. Retinal and choroidal vasculature in rats with spontaneous diabetes type 2 treated with the angiotensin-converting enzyme inhibitor cilazapril: corrosion cast and electron-microscopic study. Ophthalmic Res 2002;34:220-31.
23. Ghassemifar R, Lai CM, Rakoczy PE. VEGF differentially regulates transcription and translation of ZO-1α+ and ZO-1α- and mediates trans-epithelial resistance in cultured endothelial and epithelial cells. Cell Tissue Res 2006;323:117-25.
24. Schwesinger C, Yee C, Rohan RM, et al. Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium. Am J Pathol 2001;158:1161-72.
25. Xiao Q, Zeng S, Ling S, et al. Up-regulation of HIF-1α and VEGF expression by elevated glucose concentration and hypoxia in cultured human retinal pigment epithelial cells. J Huazhong Univ Sci Technolog Med Sci 2006;26:463-5.