Bridging critical nerve defects through an acellular homograft seeded with autologous schwann cells obtained from a regeneration neuroma of the proximal stump

Journal of Reconstructive Microsurgery

Volumn 24, Issue 3, 2008, Pages 151-158

  Aszmann, Oskar C ^a,b   Korak, Klaus J ^a   Luegmair, Matthias ^a   Frey, Manfred ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Nerve defects; Nerve regeneration; Neuroma

Indexed keywords

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOGRAFT; CELL TRANSPLANTATION; CONTROLLED STUDY; HISTOLOGY; IN VITRO STUDY; MORPHOMETRICS; NERVE BIOPSY; NERVE FIBER; NERVE GRAFT; NERVE INJURY; NEUROMA; NONHUMAN; PRIORITY JOURNAL; RAT; SCHWANN CELL; SENSORY NERVE CELL;

ANIMALS; AXONS; CELL DIFFERENTIATION; ELECTRIC STIMULATION; GUIDED TISSUE REGENERATION; IMMUNOHISTOCHEMISTRY; MODELS, ANIMAL; MOTOR NEURONS; MUSCLE, SKELETAL; NERVE REGENERATION; NEUROMA; NEURONS, AFFERENT; PERIPHERAL NERVOUS SYSTEM NEOPLASMS; RATS; RATS, SPRAGUE-DAWLEY; SCHWANN CELLS; SCIATIC NERVE; TIBIAL NERVE; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HOMOLOGOUS;

EID: 45249097342     PISSN: 0743684X     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1076091     Document Type: Article

References (22)

1. Lundborg G, Dahlin L, Danielsen N, Zhao Q. Trophism, tropism, and specificity in nerve regeneration. J Reconstr Microsurg 1994;10:345-354
2. Aebischer P, Salessiotis AN, Winn SR. Basic fibroblast growth factor from synthetic guidance channels facilitates peripheral nerve regeneration across long nerve gaps. J Neurosci Res 1989;23:282-289
3. Calder JS, Green CJ. Nerve-muscle sandwich grafts: the importance of Schwann cells in peripheral nerve regeneration through muscle basal lamina conduits. J Hand Surg [Br] 1995;20:423-428
4. Chen LE, Seaber AV, Urbaniak JR, Murrell GA. Denatured muscle as a nerve conduit: a functional, morphologic and electrophysiologic evaluation. J Reconstr Microsurg 1994;10:137-144
5. Chiu DT, Janecka I, Krizek TJ, Wolff M, Lovelace RE. Autogenous vein graft as a conduit for nerve regeneration. Surgery 1982;91:226-233
6. Heijke GC, Klopper PJ, Dutrieux RP. Veingrafts conduits versus conventional suturing in peripheral nerve reconstruction. Microsurgery 1993;14:584-588
7. Mackinnon SE, Dellon AL. Clinical nerve reconstruction with a bioabsorbable polyglycolid acid tube. Plast Reconstr Surg 1990;85:419-424
8. Madison R, Da Siiva CF, Dikkes P, Chiu TH, Sidman RL. Increased rate of peripheral nerve regeneration using bioabsorbable nerve guides and a laminin containing gel. Exp Neurol 1985;88:767-772
9. Madison RD, Da Silva CF, Dikkes P, Sidman RL, Chiu TH. Peripheral nerve regeneration with entubulation repair: comparison of biodegradable nerve guides versus polyethylene tubes and the effects of a laminin containing gel. Exp Neurol 1987;95:378-390
10. Davis GE, Blaker SN, Engvall E, Varon S, Manthorpe M, Gage FH. Human amnion membrane serves as a substratum for growing axons in vitro and in vivo. Science 1987;236:1106-1109
11. Evans PJ, Bain JR, Mackinnon SE, Makino AP, Hunter DA. Selective reinnervation - a comparison of recovery following microsuture and conduit nerve repair. Brain Res 1991;559:315-321
12. Feneley MR, Fawcett JW, Keynes RJ. The role of Schwann cells in the regeneration of peripheral nerve axons through muscle basal lamina grafts. Exp Neurol 1991;114:275-285
13. Fansa H, Keilhoff G, Wolf G, Schneider W. Tissue engineering of peripheral nerves: a comparison of venous and acellular muscle grafts with cultured Schwann cells. Plast Reconstr Surg 2001;107:485-494
14. Mosahebi A, Simon M, Wiberg M, Terenghi G. A novel use of alginate hydrogel as Schwann cell matrix. Tissue Eng 2001;7:525-531
15. Strauch B, Rodriguez DM, Diaz H, Yu HL, Kaplan G, Weinstein DE. Autologous Schwann cells drive regeneration through a 6-cm autogenous venous nerve conduit. J Reconstr Microsurg 2001;17:589-595
16. Rodriguez FJ, Verdu E, Ceballos D, Navarro X. Nerve guides seeded with autologous Schwann cells improve nerve regeneration. Exp Neurol 2000;161:571-584
17. Funakoshi H, Frisen J, Barbany G, et al. Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. J Cell Biol 1993;123:455-465
18. Sorensen J, Fugleholm K, Moldovan M, Schmalbruch H, Krarup Ch. Axonal elongation through long acellular nerve segments depends on recruitment of phagocytic cells from the near-nerve environment. Electrophysiological and morphological studies in the cat. Brain Res 2001;903:185-197
19. Sondell M, Lundborg G, Kanje M. Vascular endothelial growth factor stimulates Schwann cell invasion and neovascularisation of acellular nerve grafts. Brain Res 1999;846:219-228
20. Terenghi G. Peripheral nerve injury and regeneration. Histol Histopathol 1995;10:709-718
21. Ansselin AD, Fink T, Davey DF. Peripheral nerve regeneration through nerve guides seeded with adult Schwann cells. Neuropathol Appl Neurobiol 1997;23:387-398
22. Maeda T, Mackinnon SE, Best TJ, Evans PJ, Hunter DA, Midha R. Regeneration across "stepping stone" nerve grafts. Brain Res 1993;618:196-202