Novel HLA-G-Binding Leukocyte Immunoglobulin-Like Receptor (LILR) Expression Patterns in Human Placentas and Umbilical Cords

Placenta

Volumn 29, Issue 7, 2008, Pages 631-638

  McIntire, R H ^a   Sifers, T ^a   Platt, J S ^a   Ganacias, K G ^a   Langat, D K ^a   Hunt, J S ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Human placenta; Human umbilical cord; Leukocyte immunoglobulin like receptor (LILRB); Receptors for HLA G

Indexed keywords

HLA G ANTIGEN; LEUKOCYTE ANTIBODY; PROTEIN LILRB1; PROTEIN LILRB2;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; PLACENTA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; UMBILICAL CORD;

ANTIGENS, CD; CELLS, CULTURED; EXTRAEMBRYONIC MEMBRANES; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; IMMUNITY, NATURAL; MEMBRANE GLYCOPROTEINS; MESODERM; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PLACENTA; PREGNANCY; PROTEIN BINDING; RECEPTORS, IMMUNOLOGIC; RNA, MESSENGER; UMBILICAL CORD;

EID: 45249090113     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.placenta.2008.04.007     Document Type: Article

References (26)

1. Ellis S.A., Sargent I.L., Redman C.W., and McMichael A.J. Evidence for a novel HLA antigen found on human extravillous trophoblast and a choriocarcinoma cell line. Immunology 59 (1986) 595-601
2. Kovats S., Main E.K., Librach C., Stubblebine M., Fisher S.J., and DeMars R. A class I antigen, HLA-G, expressed in human trophoblasts. Science 248 (1990) 220-223
3. Morales P.J., Pace J.L., Platt J.S., Phillips T.A., Morgan K., Fazleabas A.T., et al. Placental cell expression of HLA-G2 isoforms is limited to the invasive trophoblast phenotype. J Immunol 171 (2003) 6215-6224
4. 2-microglobulin-free, disulfide-linked HLA-G5 homodimers in human placental villous cytotrophoblast cells. Immunology 122 (2007) 179-188
5. Hunt J.S., Petroff M.G., McIntire R.H., and Ober C. HLA-G and immune tolerance in pregnancy. FASEB J 19 (2005) 681-693
6. Hunt J.S. Stranger in a strange land. Immunol Rev 213 (2006) 36-47
7. Pistoia V., Morandi F., Wang X., and Ferrone S. Soluble HLA-G: are they clinically relevant?. Semin Cancer Biol 17 (2007) 469-479
8. Favier B., LeMaoult J., and Carosella E.D. Functions of HLA-G in the immune system. Tissue Antigens 69 Suppl. 1 (2007) 150-152
9. Petroff M.G., Sedlmayr P., Azzola D., and Hunt J.S. Decidual macrophages are potentially susceptible to inhibition by class Ia and class Ib HLA molecules. J Reprod Immunol 56 (2002) 3-17
10. Allan D.S., McMichael A.J., and Braud V.M. The ILT family of leukocyte receptors. Immunobiology 202 (2000) 34-41
11. Shiroishi M., Tsumoto K., Amano K., Shirakihara Y., Colonna M., Braud V.M., et al. Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. Proc Natl Acad Sci U S A 100 (2003) 8856-8861
12. Manavalan J.S., Kim-Schulze S., Scotto L., Naiyer A.J., Vlad G., Colombo P.C., et al. Alloantigen specific CD8+ CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity. Int Immunol 16 (2004) 1055-1068
13. Le Bouteiller P., Pizzato N., Barakonyi A., and Solier C. HLA-G, pre-eclampsia, immunity and vascular events. J Reprod Immunol 59 (2003) 219-234
14. Fons P., Chabot S., Cartwright J.E., Lenfant F., L'Faqihi F., Giustiniani J., et al. Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells. Blood 108 (2006) 2608-2615
15. Le Bouteiller P., Fons P., Herault J.-P., Bono F., Chabot S., Cartwright J.E., et al. Soluble HLA-G and control of angiogenesis. J Reprod Immunol 76 (2007) 17-22
16. Langat DL, Wheaton DA, Platt JS, Sifers T, Hunt JS. BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand): potential signaling pathways in human placental villi. Amer J Pathol, in press.
17. Barnstable C.J., Bodmer W.F., Brown G., Galfre G., Milstein C., Williams A.F., et al. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens: new tools for genetic analysis. Cell 14 (1978) 9-20
18. Pace J.L., Morales P.J., Phillips T.A., and Hunt J.S. Analysis of the soluble isoforms of HLA-G. In: Soares M.J., and Hunt J.S. (Eds). Placenta and Trophoblast Methods and Protocols vol. 122 (2006), Human Press, Totowa, NJ, USA 181-203
19. Lien E., Liabakk N.B., and Austgulen R. Detection of soluble receptors for tumor necrosis factor, interleukin-2 and interleukin-6 in retroplacental serum from normal pregnant women. Gynecol Obstet Invest 41 (1996) 1-4
20. Vince G.S., and Johnson P.M. Immunobiology of human uteroplacental macrophages - friend and foe?. Placenta 17 (1996) 191-199
21. Blaschitz A., Lenfant F., Mallet V., Hartmann M., Bensussan A., Geraghty D.E., et al. Endothelial cells in chorionic fetal vessels of first trimester placenta express HLA-G. Eur J Immunol 27 (1997) 3380-3388
22. Gleissner C.A., Zastrow A., Klingenberg R., Kluger M.S., Konstandin M., Celik S., et al. IL-10 inhibits endothelium-dependent T cell costimulation by upregulation of ILT3/4 in human vascular endothelial cells. Eur J Immunol 37 (2007) 177-192
23. Roth I., Corry D.B., Locksley R.M., Abrams J.S., Litton M.J., and Fisher S.J. Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin-10. J Exp Med 184 (1996) 536-548
24. Shiroishi M., Kuroki K., Rasubala L., Tsumoto K., Kumagai I., Kurimoto E., et al. Structural basis for recognition of the non-classical MHC molecule HLA-G by the leukocyte Ig-like receptor B2. Proc Natl Acad Sci U S A 103 (2006) 16412-16417
25. Bondarenko G.I., Burleigh D.W., Durning M., Breburda E.E., Grendell R.L., and Golos T.G. Passive immunization against the MHC class I molecule Mamu-AG disrupts rhesus placental development and endometrial responses. J Immunol 179 (2007) 8042-8050
26. Seval Y., Korgun E.T., and Demir R. Hofbauer cells in early human placenta: possible implications in vasculogenesis and angiogenesis. Placenta 28 (2007) 841-845