Property distribution in the chemical space of PPAR-γ agonists: Evaluation of drug-like characteristics

Review of Clinical Pharmacology and Pharmacokinetics, International Edition

Volumn 22, Issue 2, 2008, Pages 366-368

  Giaginis, C ^a,b   Zira, A ^a,b   Theocharis, S ^b   Tsantili Kakoulidou, A ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

ADME Tox; Druglike properties; Lipophilicity; PPAR agonists; Rule of 5

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST;

CONFERENCE PAPER; DIABETES MELLITUS; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; LIPOPHILICITY; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; TRANSACTIVATION;

EID: 45149134005     PISSN: 10116583     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (6)

1. Kerns E.H.: High throughput physicochemical profiling for drug discovery. J. Pharm. Sci. 90: 1838-1858 (2001)
2. Lipinski C.A., Lombardo F., Dominy B.W., Feeney P.J.: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Delivey Rev. 23: 3-25 (1997)
3. Muegge I.: Selection criteria for drug-like compounds. Med. Res. Rev. 23: 302-321 (2003)
4. Willson T.M., Brown P.J., Strenbach D.D., Henke B.R.: The PPARs: From orphan receptors to drug discovery. J. Med. Chem. 43: 527-550 (2000)
5. Oprea T.I.: Property distribution of drug-related chemical databases. J. Comput. Aided Mol. Des. 14: 251-264 (2000)
6. Oprea T.I., Davis A.M., Teague S.J., Leeson P.D.: Is there a difference between leads and drugs? A historical perspective. J. Chem. Inf. Comput. Sci. 41: 1308-1315 (2001)