Non-invasive in-situ detection of malignant skin tissue and other abnormalities using portable LIBS system with fiber spectrometer and Eye-safe erbium glass laser

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 6863, Issue , 2008, Pages

  Myers, Michael J ^a   Myers, John D ^a   Guo, Baoping ^a   Yang, Chengxin ^a   Hardy, Christopher R ^a   Myers, Jeffrey A ^a   Myers, Abbey G ^a   Christian, Sean M ^a  

^a Kigre Inc   (United States)

Author keywords

Atomic emission line spectra; Detection of malignant skin tissue; Elemental analysis; Eye safe laser; Fiber speetrophotometer; Laser induced breakdown spectroscopy; Laser plasma spark; Portable LIBS system

Indexed keywords

(140.3500) LASERS; CLASS I; COMPUTER DISPLAYS; EMISSION DATA; EYE-SAFE; FIBER SPECTROMETER; HIGH PEAK POWERS; IN-SITU; LASER DEVICES; LASER SPARKS; LASER-INDUCED BREAKDOWN SPECTROSCOPY (LIBS); LINE SPECTRUM; MALIGNANT SKIN; MATERIAL ANALYSES; NON INVASIVE; OPTICAL DIAGNOSTICS; PEAK POWERS; Q-SWITCHED LASERS; SAMPLE PREPARATIONS; VISIBLE AND NEAR INFRARED (VNIR);

COMPUTER AIDED ANALYSIS; COMPUTER NETWORKS; COMPUTERS; EMISSION SPECTROSCOPY; ERBIUM; EYE PROTECTION; FIBER OPTICS; LAPTOP COMPUTERS; LASER BEAMS; LASER PULSES; LASER SPECTROSCOPY; PULSED LASER APPLICATIONS; PULSED LASER DEPOSITION; Q SWITCHED LASERS; Q SWITCHING; REAL TIME SYSTEMS; SKIN; SPECTROSCOPIC ANALYSIS; SUGAR (SUCROSE); TISSUE;

LASERS;

EID: 45149100338     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.764685     Document Type: Conference Paper

References (19)

1. A. Kumar, F. Yueh, J. Singh, S. Burgess, "Characterization of Malignant Tissue Cells by Laser-Induced Breakdown Spectroscopy," Applied Optics, Vol. 43, No. 28, Oct. 1, 2004.
2. US Food and Drug Administration, Center for Devices and Radiological Health, CDRH 1040.10 and American National Standards Institute ANSI 136.1 MPE level standards
3. Y. Werner-Linde, J. Pallon, B. Forslind, "Physiologically Important Trace Elements of Paralesional Psoriatic Skin," Scanning Microscopy Vol. 12, No. 4, Pp 599-608, 1998.
4. C. Cullander, S. Jeske, D. Imbert, P. Grant, G. Bench, "A Quantitative Minimally Invasive Assay for the Detection of Metals in the Strartum Corneum," Journal of Pharmaceutical and Biomedical Analysis," 22, pp 265-279, 2000.
5. Y. Barbotteau, E. Gontier, P. Barbeeret, M. Cappadoro, B. De Wever, C. Habchi, S. Incerti, A. Mavon, P. Moretto, T. Pouthier, R. Smith, M. Ynsa, "Reconstructed Human Epidermis: A Model to Study the Barrier Funtion," Nuclear Instruments and Methods in Physics Research B 231 pp286-291, 2005.
6. + Gradients in Murine Epidermis: Quantitative Measurement Using PIXE," Journal of Investigative Dermatology, Vol. 111. No. 6, pp. 1198-1201, Dec. 1998.
7. H. Brown, "The Mineral Content of Human Skin," Journal of Biological Chemistry, pp789-794, 1927.
8. E. McCollum, O. Rask, J. Ernestine, "A Study of the Possible Role of Aluminum Componds in Animal and Plant Physiology", Journal of Biological Chemistry, pp753-767, 1928.
9. http://www.physics.nist.gov/PhysRefData/ASD/lines_form.html NIST, National Institute of Standards and Technology for the United States of America.
10. http://www.arl.army.mil/www/default.cfm?Action=247&Page=250 ARL, US Army Research Laboratory.
11. M. Adamson, "LIBS for Detection of Trace Aluminum in Human Tissue Simulants," Wayne State University. Dept. of Physics, Published on-line http://www.physics. wayne.edu/∼srehse/LIBSonTissues.html.
12. Integrated Ocean Drilling Program, Publication Services, Plasma Spectroscopy (ICP-AES run parameters, http://www-odp.tamu.edu/publications/ 192_IR/chap_02/c2_t2.htm.
13. University of Minnesota, College of Agricultural, Food, and Environmental Sciences, Department of Soil, Water, and Climate, Research Analytical Laboratory, Ion Conductive Plasma Calibration Standards, http://ral.coafes.umn. edu/ICP-3560.htm.
14. G. Iyengar, W. Kollmer, H. Bowen, "The Elemental Composition of Human Body Fluids", A Compilation fro Adults, Verlag Chemie, Weinheim, Germany, pp. 51-54, 1978.
15. M. Illario, A. Cavallo, S. Monaco, E. Vito, F. Mueller, L. Marzano, G. Troncone, G. Fenzi, G. Rossi, M. Vitale, "FN-Induced Proliferation in Thyroid Cells is Mediated by avB3 Integrin Through Ras/Raf-1/Mek/Erk and Calcium/CaMKII Signals", Journal of Clinical Endocrinology & Metabolism, doi: 10.1210/jc.2004-1520, Feb. 2005.
16. E. Drake, H. Sky-Peck, "Discriminant Analysis of Trace Element Distribution in Normal and Malignant Human Tissues", Cancer Research, 49, 4210-4215, Aug. 1989.
17. S. Stitch, "Trace Elements in Human Tissue", Bioch. Vol. 67, pp. 97-103, 1957.
18. G. Iyengar, W. Kollmer, H. Bowen, "The Elemental Composition of Human Tissues and Body Fluids", Verlag Chemie GmbH, Weinheim, Germany, pp. 100-102, 1978.
19. rd International Conference on Laser Induced Plasma Spectroscopy and Applications, Malaga, Spain Sept. 29, 2004.