Combined treatment of aspartyl protease inhibitor and Nmda antagonist in Pc12 cells after glutamate excitotoxicity

Review of Clinical Pharmacology and Pharmacokinetics, International Edition

Volumn 22, Issue 2, 2008, Pages 304-307

  Pourzitaki, C ^a   Kanellos, G ^a   Klagas, I ^a   Kritis, A ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Cell death; Glutamate; MK801; NGF; PC12; Pepstatin A; Toxicity

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ASPARTIC PROTEINASE; DIZOCILPINE; GLUTAMIC ACID; NERVE GROWTH FACTOR; PEPSTATIN;

ANIMAL CELL; CELL DEATH; CELL PROTECTION; CELL STRAIN; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; EXCITOTOXICITY; NERVE CELL EXCITABILITY; NONHUMAN; PHENOTYPE; RAT; SYMPATHETIC TONE;

EID: 45149092682     PISSN: 10116583     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (5)

1. Greene L.A., Aletta J.M., Rukenstein A., Green S.H.: PC12 pheochromocytoma cells: culture, nerve growth factor treatment, and experimental expbitation. Methods Enzymol. 147: 207-216 (1987)
2. Choi D.W., Hartley D.M.: Calcium and glutamate-induced cortical neuronal death, In: (S.G. Waxman, ed.) Molecular and Cellular Approaches to the Treatment of Neurological Disease. Pp. 23-34, Raven Press, New York, 1993
3. Hossmann K.A.: Glutamate-mediated injury in focal cerebral ischemia: the excitotoxin hypothesis revised. Brain Pathol. 4: 23-36 (1994)
4. Choi D.W.: Glutamate neurotoxicity and diseases of the nervous system. Trends Neurosci. 11: 465-469 (1988)
5. Vaux D.L., Korsmeyer S.J.: Cell death in development. Cell 96: 245-254 (1999)