Targeted dendrimer-based contrast agents for articular cartilage assessment by MR imaging

Osteoarthritis and Cartilage

Volumn 16, Issue 7, 2008, Pages 815-822

  Winalski, C S ^a,b   Shortkroff, S ^b   Schneider, E ^a,c   Yoshioka, H ^b   Mulkern, R V ^d   Rosen, G M ^e,f,g  

^a LERNER RESEARCH INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c SciTrials LLC   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^f UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^g NitroSci   (United States)

Author keywords

Cartilage; Contrast agent; Dendrimer linked nitroxides; Glycosaminoglycan; Magnetic resonance imaging; Relaxivity

Indexed keywords

3 TRIMETHYLAMINOMETHYL 2,2,5,5 TETRAMETHYL1 PYRROLIDINYLOXYL IODIDE; CONTRAST MEDIUM; DENDRIMER; GADOLINIUM PENTETATE; GLYCOSAMINOGLYCAN; NITROXIDE DERIVATIVE; POLYAMIDOAMINE; POLYMER; POLYPROPYLENEIMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; CONCENTRATION RESPONSE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; COW; DRUG HALF LIFE; DRUG STRUCTURE; DRUG TARGETING; DRUG TISSUE LEVEL; HINDLIMB; HISTOPATHOLOGY; IMAGE ANALYSIS; IMAGE ENHANCEMENT; IN VIVO STUDY; KNEE; NECROSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATELLA; PRIORITY JOURNAL; SCORING SYSTEM; STRUCTURE ANALYSIS; SYNOVIAL FLUID; SYNOVITIS;

ANIMALS; CARTILAGE, ARTICULAR; CATTLE; CONTRAST MEDIA; DENDRIMERS; DRUG EVALUATION, PRECLINICAL; GADOLINIUM DTPA; HALF-LIFE; MAGNETIC RESONANCE IMAGING; MOLECULAR WEIGHT; NITROGEN OXIDES; PATELLA; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE CULTURE TECHNIQUES;

EID: 45049088638     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2007.10.015     Document Type: Article

References (31)

1. Buckwalter J.A., and Mankin H.J. Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. J Bone Joint Surg Am 79 (1997) 612-632
2. Felson D.T., Lawrence R.C., Dieppe P.A., Hirsch R., Helmick C.G., Jordan J.M., et al. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med 133 (2000) 635-646
3. Pelletier J.P., Haraoui B., and Fernandes J.C. New and future therapies for osteoarthritis. In: Reginster J.-Y., Pelletier J.-P., Martel-Pelletier J., and Henrotin Y. (Eds). Osteoarthritis. Clinical and Experimental Aspects (1999), Springer-Verlag, Berlin, Germany 387-408
4. Smith Jr. G.N., Myers S.L., Brandt K.D., Mickler E.A., and Albrecht M.E. Diacerhein treatment reduces the severity of osteoarthritis in the canine cruciate-deficiency model of osteoarthritis. Arthritis Rheum 42 (1999) 545-554
5. Potter H.G., Linklater J.M., Allen A.A., Hannafin J.A., and Haas S.B. Magnetic resonance imaging of articular cartilage in the knee. An evaluation with use of fast-spin-echo imaging. J Bone Joint Surg Am 80 (1998) 1276-1284
6. Recht M.P., Kramer J., Marcelis S., Pathria M.N., Trudell D., Haghighi P., et al. Abnormalities of articular cartilage in the knee: analysis of available MR techniques. Radiology 187 (1993) 473-478
7. Mosher T.J., Dardzinski B.J., and Smith M.B. Human articular cartilage: influence of aging and early symptomatic degeneration on the spatial variation of T2 - preliminary findings at 3 T. Radiology 214 (2000) 259-266
8. Bashir A., Gray M.L., Boutin R.D., and Burstein D. Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging. Radiology 205 (1997) 551-558
9. Gold G.E., Thedens D.R., Pauly J.M., Fechner K.P., Bergman G., Beaulieu C.F., et al. MR imaging of articular cartilage of the knee: new methods using ultrashort TEs. AJR Am J Roentgenol 170 (1998) 1223-1226
10. Wolff S.D., Chesnick S., Frank J.A., Lim K.O., and Balaban R.S. Magnetization transfer contrast: MR imaging of the knee. Radiology 179 (1991) 623-628
11. Rubenstein J.D., Li J.G., Majumdar S., and Henkelman R.M. Image resolution and signal-to-noise ratio requirements for MR imaging of degenerative cartilage. AJR Am J Roentgenol 169 (1997) 1089-1096
12. Maroudas A. Distribution and diffusion of solutes in articular cartilage. Biophys J 10 (1970) 365-379
13. Maroudas A., and Evans H. A study of ionic equilibria in cartilage. Connect Tissue Res 1 (1972) 69-77
14. Winalski C.S., Shortkroff S., Mulkern R.V., Schneider E., and Rosen G.M. Magnetic resonance relaxivity of dendrimer-linked nitroxides. Magn Reson Med 48 (2002) 965-972
15. Pou S., Davis P.L., Wolf G.L., and Rosen G.M. Use of nitroxides as NMR contrast enhancing agents for joints. Free Radic Res 23 (1995) 353-364
16. Bacic G., Liu K.J., Goda F., Hoopes P.J., Rosen G.M., and Swartz H.M. MRI contrast enhanced study of cartilage proteoglycan degradation in the rabbit knee. Magn Reson Med 37 (1997) 764-768
17. Bosman A.W., Janssen R.A.J., and Meijer E.W. Five generations of nitroxyl-functionalized dendrimers. Macromolecules 30 (1997) 3606-3611
18. Lindblad S., and Hedfors E. Intraarticular variation in synovitis. Local macroscopic and microscopic signs of inflammatory activity are significantly correlated. Arthritis Rheum 28 (1985) 977-986
19. Mankin H.J., Dorfman H., Lippiello L., and Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 53 (1971) 523-537
20. Buckwalter J.A., and Mankin H.J. Articular cartilage: tissue design and chondrocyte-matrix interactions. J Bone Joint Surg Am 79 (1998) 600-611
21. Lesperance L.M., Gray M.L., and Burstein D. Determination of fixed charge density in cartilage using nuclear magnetic resonance. J Orthop Res 10 (1992) 1-13
22. Reddy R., Insko E.K., Noyszewski E.A., Dandora R., Kneeland J.B., and Leigh J.S. Sodium MRI of human articular cartilage in vivo. Magn Reson Med 39 (1998) 697-701
23. Snowden J.M., and Maroudas A. The distribution of serum albumin in human normal and degenerate articular cartilage. Biochim Biophys Acta 428 (1976) 726-740
24. Schwalkwijk J., van den Berg W.B., van den Putte L.B.A., Joosten L.A.B., and van den Bersselaar L. Cationization of catalase, peroxidase, and superoxide dismutase. Effect of improved intra-articular retention on experimental arthritis in mice. J Clin Invest 76 (1985) 198-205
25. Maliakal A.J., Turro N.J., Bosman A.W., Cornel J., and Meijer E.W. Relaxivity studies on dinitroxide and polynitroxyl functionalized dendrimers: effect of electron exchange and structure on paramagnetic relaxation enhancement. J Phys Chem A 107 (2003) 8467-8475
26. Yordanov A.T., Yamada K., Krishna M.C., Mitchell J.B., Woller E., Cloninger M., et al. Spin-labeled dendrimers in EPR imaging with low molecular weight nitroxides. Angew Chem Int Ed Engl 40 (2001) 2690-2692
27. Bashir A., Gray M.L., and Burstein D. Gd-DTPA2- as a measure of cartilage degradation. Magn Reson Med 36 (1996) 665-673
28. Gillis A., Gray M., and Burstein D. Relaxivity and diffusion of gadolinium agents in cartilage. Magn Reson Med 48 (2002) 1068-1071
29. Burstein D., Gray M.L., Hartman A.L., Gipe R., and Foy B.D. Diffusion of small solutes in cartilage as measured by nuclear magnetic resonance (NMR) spectroscopy and imaging. J Orthop Res 11 (1993) 465-478
30. Allen R.G., Burstein D., and Gray M.L. Monitoring glycosaminoglycan replenishment in cartilage explants with gadolinium-enhanced magnetic resonance imaging. J Orthop Res 17 (1999) 430-436
31. Shortkroff S, Yoshioka H, Schneider E, Rosen GM, Winalski CS. MR measurement of contrast diffusion into cartilage. In: 6th Symposium of the International Cartilage Repair Society. San Diego, CA, 2006.