Intra-articular injection of interleukin-4 decreases nitric oxide production by chondrocytes and ameliorates subsequent destruction of cartilage in instability-induced osteoarthritis in rat knee joints

Osteoarthritis and Cartilage

Volumn 16, Issue 7, 2008, Pages 764-771

  Yorimitsu, M ^a   Nishida, K ^a   Shimizu, A ^b   Doi, H ^a   Miyazawa, S ^a   Komiyama, T ^a   Nasu, Y ^a   Yoshida, A ^a   Watanabe, S ^b   Ozaki, T ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Chondrocyte; Interleukin 4; Mechanical stress; Nitric oxide; Osteoarthritis

Indexed keywords

3 NITROTYROSINE; AGGRECAN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRIC OXIDE; RECOMBINANT INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR CRUCIATE LIGAMENT; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL PROTECTION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KNEE LIGAMENT; KNEE MENISCUS; KNEE OSTEOARTHRITIS; MECHANICAL STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SCORING SYSTEM; TISSUE SECTION;

AGGRECANS; ANIMALS; ARTHRITIS, EXPERIMENTAL; CELLS, CULTURED; CHONDROCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMUR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INJECTIONS, INTRA-ARTICULAR; INTERLEUKIN-4; MECHANOTRANSDUCTION, CELLULAR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OSTEOARTHRITIS; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STRESS, MECHANICAL; TYROSINE;

EID: 45049087555     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2007.11.006     Document Type: Article

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