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This paper provides evidence for an interesting use of the zebrafish Par3 homologue by neural progenitor cells to produce two progenitor cells that are integrated into different sides of the neural tube.
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This paper provides evidence for a novel cellular mechanism in mammals that uses fragmentation and reconstitution of the Golgi apparatus to precisely coordinate cell-cycle progression and cell-fate specification during an asymmetric cell division. This mechanism helps to explain why Numb signalling can play two seemingly contradictory roles in specifying neural progenitor fates and also neuronal differentiation.
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Zhou Y., Atkins J.B., Rompani S.B., Bancescu D.L., Petersen P.H., Tang H., Zou K., Stewart S.B., and Zhong W. The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis. Cell 129 (2007) 163-178. This paper provides evidence for a novel cellular mechanism in mammals that uses fragmentation and reconstitution of the Golgi apparatus to precisely coordinate cell-cycle progression and cell-fate specification during an asymmetric cell division. This mechanism helps to explain why Numb signalling can play two seemingly contradictory roles in specifying neural progenitor fates and also neuronal differentiation.
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Cell
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Zhou, Y.1
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Tang, H.6
Zou, K.7
Stewart, S.B.8
Zhong, W.9
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