Short-course preoperative radiotherapy with delayed surgery in rectal cancer - A retrospective study

Radiotherapy and Oncology

Volumn 87, Issue 3, 2008, Pages 343-349

  Radu, Calin ^a   Berglund, Åke ^a   Påhlman, Lars ^b   Glimelius, Bengt ^a,c  

^a Department of Oncology Radiology and Clinical Immunology

^b UPPSALA UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

5 5 Gy; Delay surgery; Non resectable; Radiotheraphy; Rectal cancer

Indexed keywords

CAPECITABINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; COMORBIDITY; CONTROLLED STUDY; DIARRHEA; FEBRILE NEUTROPENIA; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; MALE; METASTASIS; MONOTHERAPY; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; RADIATION DOSE; RECTUM CANCER; RETROSPECTIVE STUDY; THERAPY DELAY; TREATMENT DURATION;

AGED; AGED, 80 AND OVER; DOSE FRACTIONATION; FEMALE; HUMANS; MALE; MIDDLE AGED; RADIATION INJURIES; RADIOTHERAPY DOSAGE; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 45049086609     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2007.11.025     Document Type: Article

References (19)

1. Frykholm G., Glimelius B., and Påhlman L. Preoperative irradiation with and without chemotherapy (MFL) in the treatment of primary non-resectable adenocarcinoma of the rectum. Results from two consecutive studies. Eur J Cancer Clin Oncol 25 (1989) 1535-1541
2. Sauer R., Becker H., Hohenberger W., et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351 (2004) 1731-1740
3. Sebag-Montefiore D. Developments in the use of chemoradiotherapy in rectal cancer. Colorectal Dis 8 (2006) 14-17
4. Swedish Rectal Cancer Trial. Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med 1997;336:980-7.
5. Kapiteijn E., Marijnen C.A.M., Nagtegaal I.D., et al. Preoperative radiotherapy in combination with total mesorectal excision improves local control in resectable rectal cancer. Report from a multicenter randomized trial. New Engl J Med 345 (2001) 638-646
6. Peeters K.C.M.J., Marijnen C.A.M., Nagtegaal I.D., et al., For the Dutch Colorectal Cancer Group. The TME trial after a median follow-up of 5 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg 246 (2007) 693-701
7. Glimelius B., Grönberg H., Järhult J., Wallgren A., and Cavallin-ståhl E. A systematic overview of radiation therapy effects in rectal cancer. Acta Oncol 42 (2003) 476-492
8. Glimelius B. Rectal cancer irradiation. Long course, short course or something else?. Acta Oncol 45 (2006) 1013-1017
9. Gerard J.P., Conroy T., Bonnetain F., et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203. J Clin Oncol 24 (2006) 4620-4625
10. Bosset J.F., Collette L., Calais G., et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 355 (2006) 1114-1123
11. Widder J., Herbst F., and Scheithauer W. Preoperative sequential short-term radiotherapy plus chemotherapy can induce complete remission in T3N2 rectal cancer. Acta Oncol 44 (2005) 921-923
12. Sørbye H., Glimelius B., Berglund Å., et al. Multicentre phase II study of Nordic 5-fluorouracil/leucovorin bolus schedule combined with oxaliplatin (FLOX) as first-line treatment of metastatic colorectal cancer. J Clin Oncol 22 (2004) 31-38
13. de Gramont A., Figer A., Seymour M., et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18 (2000) 2938-2947
14. Bujko K., Nowacki M.P., Nasierowska-Guttmejer A., et al. Long-term results of a randomised trial comparing preoperative short-course radiotherapy vs preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg 93 (2006) 1215-1223
15. Desch C.E., Benson III A.B., Smith T.J., et al. Recommended colorectal cancer surveillance guidelines by the American Society of Clinical Oncology. J Clin Oncol 17 (1999) 1312-1321
16. Braendengen M, Tveit KM, Berglund Å, et al. A randomized phase III study (LARCS) comparing preoperative radiotherapy alone versus chemoradiotherapy in non-resectable rectal cancer. Eur J Cancer 2005; ECCO 13. Abstr 612.
17. Courdi A. Fractionation sensitivity and equivalent doses. Commenting the Editorial by Glimelius. Acta Oncol 46 (2007) 395-396 [author reply 396]
18. Glimelius B., and Isacsson U. In reply to Dr. Courdi. Acta Oncol 46 (2007) 396
19. Smith N., and Brown G. Preoperative staging of rectal cancer. Acta Oncol 47 (2008) 1-12