Role of the interleukin 15 96516A > T and IL15 96330C > A gene polymorphisms in caucasian patients with chronic plaque psoriasis

Journal of Dermatological Science

Volumn 51, Issue 2, 2008, Pages 147-149

  Weger, Wolfgang ^a   Hofer, Angelika ^a   Wolf, Peter ^a   El Shabrawi, Yosuf ^a   Renner, Wilfried ^a   Kerl, Helmut ^a   Salmhofer, Wolfgang ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Chronic plaque psoriasis; Gene polymorphism; Interleukin 15; Risk factor

Indexed keywords

INTERLEUKIN 15;

ADULT; CAUCASIAN; CONTROLLED STUDY; DISEASE SEVERITY; DNA ISOLATION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PSORIASIS VULGARIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CASE-CONTROL STUDIES; CHRONIC DISEASE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-15; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PSORIASIS;

EID: 45049084651     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2008.02.010     Document Type: Letter

References (10)

1. Villadsen L.S., Schuurman J., Beurskens F., Dam T.N., Dagnaes-Hansen F., Skov L., et al. Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model. J Clin Invest 112 (2003) 1571-1580
2. Rückert R., Asadullah K., Seifert M., Budagian V.M., Arnold R., Trombotto C., et al. Inhibition of keratinocyte apoptosis by IL-15: a new parameter in the pathogenesis of psoriasis?. J Immunol 165 (2000) 2240-2250
3. Nickoloff B.J., Bonish B., Huang B.B., and Porcelli S.A. Characterization of a T cell line bearing natural killer receptors and capable of creating psoriasis in a SCID mouse model system. J Dermatol Sci 24 (2000) 212-225
4. D́Auria L., Bonifati C., Cordiali-Fei P., Leone G., Picardo M., Pietravalle M., et al. Increased serum interleukin-15 levels in bullous skin diseases: correlation with disease intensity. Arch Dermatol Res 291 (1999) 354-356
5. Fehniger T.A., and Caliguri M.A. Interleukin 15: biology and relevance to human disease. Blood 97 (2001) 14-32
6. Zhang X.J., Yan K.L., Wang Z.M., Yang S., Zhang G.L., Fan X., et al. Polymorphisms in interleukin-15 gene on chromosome 4q31.2 are associated with psoriasis vulgaris in Chinese population. J Invest Dermatol 127 (2007) 2544-2551
7. Weger W., Hofer A., Wolf P., El-Shabrawi Y., Renner W., Kerl H., et al. The angiotensin-converting enzyme insertion/deletion and the endothelin -134 3A/4A gene polymorphisms in patients with chronic plaque psoriasis. Exp Dermatol 16 (2007) 993-998
8. Yan K.L., Huang W., Zhang X.J., Yang S., Chen Y.M., Xiao F.L., et al. Follow-up analysis of PSORS9 in 151 Chinese families confirmed the linkage to 4q31-32 and refined the evidence to the families of early-onset psoriasis. J Invest Dermatol 127 (2007) 312-318
9. Lesueur F., Lefèvre C., Has C., Guilloud-Bataille M., Oudot T., Mahé E., et al. Confirmation of psoriasis susceptibility loci on chromosome 6p21 and 20p13 in French families. J Invest Dermatol 127 (2007) 1403-1409
10. Samuelsson L., Enlund F., Torinsson A., Yhr M., Inerot A., Enerbäck C., et al. A genome-wide search for genes predisposing to familial psoriasis by using a stratification approach. Hum Genet 105 (1999) 523-529