E6 and E7 oncogene expression by human papilloma virus (HPV) and the aggressive behavior of recurrent laryngeal papillomatosis (RLP)

Pediatric and Developmental Pathology

Volumn 11, Issue 2, 2008, Pages 118-121

  Shehata, Bahig M ^a,b   Otto, Kristen J ^c   Sobol, Steven E ^c   Stockwell, Christina A ^a   Foulks, Cora ^b   Lancaster, Wayne ^d   Gregoire, Lucie ^d   Hill, Charles E ^b  

^a Children's Healthcare of Atlanta ^*  (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY HOSPITAL   (United States)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Human papilloma virus (HPV); Recurrent laryngeal papillomatosis (RLP); RT PCR

Indexed keywords

ALPHA INTERFERON; CIDOFOVIR; PROTEIN E6; PROTEIN E7; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 11; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 6; ONCOPROTEIN; VIRUS DNA;

ARTICLE; CHILD; CLINICAL ARTICLE; DEBRIDEMENT; DEMOGRAPHY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 11; HUMAN PAPILLOMAVIRUS TYPE 6; HUMAN TISSUE; INFANT; LARYNX PAPILLOMATOSIS; LARYNX STENOSIS; MALE; MEDICAL RECORD; ONCOGENE; PRIORITY JOURNAL; PROGNOSIS; RECURRENT DISEASE; RETROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRACHEA RECONSTRUCTION; VIRUS VIRULENCE; WART VIRUS; ALPHAPAPILLOMAVIRUS; GENE EXPRESSION REGULATION; GENETICS; LARYNX TUMOR; PAPILLOMA; PATHOLOGY; PRESCHOOL CHILD; TUMOR RECURRENCE; VIROLOGY; VIRUS INFECTION;

ALPHAPAPILLOMAVIRUS; CHILD; CHILD, PRESCHOOL; DNA, VIRAL; FEMALE; GENE EXPRESSION REGULATION, VIRAL; HUMANS; INFANT; LARYNGEAL NEOPLASMS; MALE; NEOPLASM RECURRENCE, LOCAL; ONCOGENE PROTEINS, VIRAL; PAPILLOMA; PAPILLOMAVIRUS E7 PROTEINS; PAPILLOMAVIRUS INFECTIONS; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 44949249052     PISSN: 10935266     EISSN: 16155742     Source Type: Journal    
DOI: 10.2350/06-09-0160.1     Document Type: Article

References (17)

1. Armstrong LR, Derkay DC, Reeves WC. Initial results from the national registry for juvenile-onset recurrent respiratory papillomatosis. Arch Otolayngol Head Neck Surg 1999;125:743-748.
2. Cummings CW, Haughey BH, Thomas R, et al. Cummings Otolarngology, 4th ed. Otolaryngology Head and Neck Surgery. 4th ed. Philadelphia: Elsevier Mosby; 2005;4370-4386.
3. Doyle DJ, Gianoli GJ, Espinola T, Miller RH. Recurrent respiratory papillomatosis: juvenile versus adult forms. Laryngoscope. 1994;104:523-527.
4. Rabah R, Lancaster WD, Thomas R, Gregoire L. Human papilloma-virus-11- associated recurrent respiratory papillomatosis is more aggressive than human papillomavirus-6-associated disease. Pediatr Developmental Pathology. 2001;4:68-72.
5. Pim D, Massimi P, Dilworth SM, Banks L. Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A. Oncogene 2005;52:7380-7388.
6. Gregoire L, Lawrence WD, Kukuruga D, Eisenbrey AB, Lancaster WD. Association between HLA-DQB1 alleles and risk for cervical cancer in African-American women. Int J Cancer 1994;57:504-507.
7. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time PCR and the 2 (-Delta Delta C(T)) Method. Methods 2001;25:402-408.
8. Derkay CS. Recurrent respiratory papillomatosis. Laryngoscope 2001;111:57-69.
9. Derkay CS. Task force on recurrent respiratory papillomas: a preliminary report. Arch Otolaryngol Head Neck Surg 1995;121:1386-1391.
10. Silverberg MJ, Thorsen P, Lindeberg H, Grant LA, Shah KV. Condyloma in pregnancy is strongly predictive of juvenile-onset recurrent respiratory papillomatosis. Obstet Gynecol 2003;101:645-652.
11. Quick CA, Krzyzek RA, Watt SL, Faras AJ. Relationship between condylomata and laryngeal papillomata clinical and molecular virological evidence. Ann Otol Rhinol Laryngol 1980;89:467-471.
12. Pou AM, Rimell FL, Jordan JA, et al. Adult respiratory papillomatosis: human papillomavirus type and viral coinfections as predictors of prognosis. Ann Otol Rhin Laryngol 1995;104:758-762.
13. Yuan H, Fu F, Zhuo J, et al. Human papillomavirus type 16 E6 and E7 oncoproteins upregulate C-IAP2 gene expression and confer resistance to apoptosis. Oncogene 2005;24:5069-5078.
14. Rosty C, Sheffer M, Tsafrir D, et al. Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma. Oncogene 2005;24:7094-7104.
15. Dyson N, Howley PM, Münger K, Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 1989;243:934-937.
16. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990;63:1129-1136.
17. Scheffner M, Huibregtse JM, Vierstra RD, Howley PM. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 1993;75:495-505.